Strain Name:
C57BL/6J-MtgxR6387Btlr/Mmmh
Stock Number:
044536-MU
Citation ID:
RRID:MMRRC_044536-MU
Other Names:
R6387 (G1)
Major Collection:

Strain Information

Sparcl1
Name: SPARC-like 1
Synonyms: mast9, hevin, Sc1, Ecm2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13602
Homologene: 3438
Zfp710
Name: zinc finger protein 710
Synonyms: 5430400N05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209225
Homologene: 19625
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Emk, Par-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 3010002K18Rik, Qprs, 2410081F06Rik, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Mrps27
Name: mitochondrial ribosomal protein S27
Synonyms: 2610028H14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218506
VEGA: 13
Homologene: 41006
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 4930506D01Rik, Uhrf1bp1l, E030041M21Rik, 2010319N22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Unk
Name: unkempt family zinc finger
Synonyms: Zc3h5, B230379M23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Atp6v1a
Name: ATPase, H+ transporting, lysosomal V1 subunit A
Synonyms: VPP2, Atp6a1, lysosomal 70kDa, VA68
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11964
HGNC: HGNC:851
Homologene: 123934
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Ahi1
Name: Abelson helper integration site 1
Synonyms: D10Bwg0629e, Jouberin, 1700015F03Rik, Ahi-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Pfas
Name: phosphoribosylformylglycinamidine synthase (FGAR amidotransferase)
Synonyms: 4432409B16Rik, Sofa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237823
HGNC: HGNC:8863
Homologene: 5970
Iqcd
Name: IQ motif containing D
Synonyms: 4933433C09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75732
Homologene: 49921
Numbl
Name: numb-like
Synonyms: nbl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18223
HGNC: HGNC:8061
Homologene: 68413
4930522L14Rik
Name: RIKEN cDNA 4930522L14 gene
Synonyms: Gm42152
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041734
Csgalnact1
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Synonyms: 4732435N03Rik, CSGalNAcT-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234356
Homologene: 23099
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: multiple PDZ domain protein, B930003D11Rik, MUPP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Sympk
Name: symplekin
Synonyms: 4632415H16Rik, 1500016F02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68188
Homologene: 37969
Calcb
Name: calcitonin-related polypeptide, beta
Synonyms: CGRP2, Calc2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 116903
HGNC: HGNC:1438
Homologene: 137656
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: ST3GalI, Siat4, Siat4a, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: Ahd-2, ALDH1, E1, Raldh1, Ahd2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Zfp993
Name: zinc finger protein 993
Synonyms: Gm13248
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100503000
Smad3
Name: SMAD family member 3
Synonyms: Madh3, Smad 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17127
HGNC: HGNC:6769
Homologene: 55937
Cfap70
Name: cilia and flagella associated protein 70
Synonyms: 5330402L21Rik, Ttc18
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76670
Homologene: 17048
Ano4
Name: anoctamin 4
Synonyms: A330096O15Rik, Tmem16d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320091
Homologene: 66599
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, erythroid, Spna-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Unc5d
Name: unc-5 netrin receptor D
Synonyms: D930029E11Rik, Unc5h4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 210801
Homologene: 15450
Acot1
Name: acyl-CoA thioesterase 1
Synonyms: CTE-I, ACH2, Cte1, CTE-1, D12Ucla1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 26897
VEGA: 12
Homologene: 22686
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: Mitsugumin 56, Mg56, 1110011D13Rik, Gup1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98733
Icam4
Name: intercellular adhesion molecule 4, Landsteiner-Wiener blood group
Synonyms: Cd242, 1810015M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78369
VEGA: 9
HGNC: HGNC:5347
Homologene: 74401
Pcdhb21
Name: protocadherin beta 21
Synonyms: PcdhbU, Pcdhb18
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93892
Homologene: 134302
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Adm
Name: adrenomedullin
Synonyms: AM
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11535
HGNC: HGNC:259
Homologene: 873
Or10g9
Name: olfactory receptor family 10 subfamily G member 9
Synonyms: GA_x6K02T2PVTD-33699706-33698771, Olfr979, MOR223-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259112
VEGA: 9
Homologene: 81556
Chad
Name: chondroadherin
Synonyms: SLRR4A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12643
HGNC: HGNC:1909
Homologene: 36063
Prl4a1
Name: prolactin family 4, subfamily a, member 1
Synonyms: PLP-A, Prlpa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19110
Homologene: 7900
Ighv1-18
Name: immunoglobulin heavy variable V1-18
Synonyms: Gm16856
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629871
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 75,491,362 bp
  • G to A, chromosome 1 at 174,231,333 bp
  • T to A, chromosome 1 at 185,387,084 bp
  • A to G, chromosome 3 at 38,983,785 bp
  • A to G, chromosome 3 at 103,885,386 bp
  • T to C, chromosome 4 at 81,381,709 bp
  • A to G, chromosome 4 at 146,657,518 bp
  • T to A, chromosome 5 at 104,085,060 bp
  • T to C, chromosome 5 at 109,737,015 bp
  • T to C, chromosome 5 at 120,606,855 bp
  • T to C, chromosome 7 at 19,052,498 bp
  • C to T, chromosome 7 at 27,276,690 bp
  • T to C, chromosome 7 at 80,086,027 bp
  • T to C, chromosome 7 at 110,628,295 bp
  • G to A, chromosome 7 at 114,719,790 bp
  • T to A, chromosome 8 at 28,875,526 bp
  • C to T, chromosome 8 at 68,358,713 bp
  • A to C, chromosome 9 at 21,030,209 bp
  • A to G, chromosome 9 at 40,000,852 bp
  • G to T, chromosome 9 at 63,654,765 bp
  • T to A, chromosome 9 at 121,790,401 bp
  • A to G, chromosome 10 at 20,969,043 bp
  • A to T, chromosome 10 at 88,971,405 bp
  • C to T, chromosome 10 at 89,803,057 bp
  • A to G, chromosome 11 at 69,000,465 bp
  • C to T, chromosome 11 at 94,567,837 bp
  • A to G, chromosome 11 at 116,054,940 bp
  • A to G, chromosome 12 at 84,009,853 bp
  • T to C, chromosome 12 at 114,682,660 bp
  • T to A, chromosome 13 at 28,018,499 bp
  • A to G, chromosome 13 at 96,830,573 bp
  • A to G, chromosome 13 at 99,400,317 bp
  • C to T, chromosome 14 at 20,448,575 bp
  • T to A, chromosome 14 at 33,924,004 bp
  • A to G, chromosome 15 at 27,752,739 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to A, chromosome 16 at 14,141,640 bp
  • G to A, chromosome 16 at 15,698,815 bp
  • A to G, chromosome 16 at 44,087,443 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • A to G, chromosome 18 at 37,515,332 bp
  • A to G, chromosome 19 at 7,285,902 bp
  • A to G, chromosome 19 at 20,617,959 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6387 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044536-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.