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Strain Name:
C57BL/6J-MtgxR6455Btlr/Mmmh
Stock Number:
044591-MU
Citation ID:
RRID:MMRRC_044591-MU
Other Names:
R6455 (G1)
Major Collection:

Strain Information

Tlr9
Name: toll-like receptor 9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81897
Homologene: 68126
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Rorb
Name: RAR-related orphan receptor beta
Synonyms: RZR-beta, Nr1f2, Rorbeta, hstp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225998
Homologene: 38250
Prtg
Name: protogenin
Synonyms: A230098A12Rik, Igdcc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, IP3R1, Itpr-1, Ip3r, Pcp-1, opt, InsP3R type I, Pcp1, wblo
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Arid4a
Name: AT-rich interaction domain 4A
Synonyms: A630067N03Rik, Rbbp1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238247
HGNC: HGNC:9885
Homologene: 11303
Abca1
Name: ATP-binding cassette, sub-family A member 1
Synonyms: ABC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Bcdin3d
Name: BCDIN3 domain containing
Synonyms: 4930556P03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75284
VEGA: 15
Homologene: 12594
Utp25
Name: UTP25 small subunit processome component
Synonyms: AA408296, Diexf, mDef
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215193
Homologene: 6170
Atp2b1
Name: ATPase, Ca++ transporting, plasma membrane 1
Synonyms: PMCA1, E130111D10Rik, 2810442I22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67972
VEGA: 10
HGNC: HGNC:814
Homologene: 55597
Alms1
Name: ALMS1, centrosome and basal body associated
Synonyms: Alstrom syndrome 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 236266
HGNC: HGNC:428
Homologene: 49406
Mphosph8
Name: M-phase phosphoprotein 8
Synonyms: 1500035L22Rik, 4930548G07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75339
Homologene: 11380
Lclat1
Name: lysocardiolipin acyltransferase 1
Synonyms: ALCAT1, AGPAT8, Lycat
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225010
Homologene: 33167
Amtn
Name: amelotin
Synonyms: 5430427O21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71421
Homologene: 52640
Wbp2
Name: WW domain binding protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22378
Homologene: 32160
Tia1
Name: cytotoxic granule-associated RNA binding protein 1
Synonyms: mTIA-1, 2310050N03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21841
Homologene: 20692
Pkd2
Name: polycystin 2, transient receptor potential cation channel
Synonyms: polycystin-2, C030034P18Rik, TRPP2, PC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18764
HGNC: HGNC:9009
Homologene: 20104
Epn2
Name: epsin 2
Synonyms: Ibp2, 9530051D10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13855
Homologene: 40710
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Wdr18
Name: WD repeat domain 18
Synonyms: 2310012I10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216156
VEGA: 10
Homologene: 32573
Eif5b
Name: eukaryotic translation initiation factor 5B
Synonyms: IF2, A030003E17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226982
Homologene: 134613
Heatr5b
Name: HEAT repeat containing 5B
Synonyms: D330050P16Rik, 2010013B10Rik, A230048G03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320473
VEGA: 17
Homologene: 25536
Cd22
Name: CD22 antigen
Synonyms: Lyb-8, Lyb8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12483
HGNC: HGNC:1643
Homologene: 31052
Myo7a
Name: myosin VIIA
Synonyms: Myo7, USH1B, nmf371, polka, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Raldh2, Aldh1a7, retinaldehyde dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19378
Homologene: 68368
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, Ptpri, PTPL1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Myog
Name: myogenin
Synonyms: myo, bHLHc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17928
HGNC: HGNC:7612
Homologene: 1854
Tnn
Name: tenascin N
Synonyms: Tnw, tenascin-W
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329278
Homologene: 18634
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Rpgrip1
Name: retinitis pigmentosa GTPase regulator interacting protein 1
Synonyms: A930002K18Rik, 4930505G06Rik, 4930401L23Rik, nmf247
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 77945
Homologene: 10679
Gpr75
Name: G protein-coupled receptor 75
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237716
HGNC: HGNC:4526
Homologene: 4945
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Abca6
Name: ATP-binding cassette, sub-family A member 6
Synonyms: 6330565N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76184
HGNC: HGNC:36
Homologene: 71264
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Ina
Name: internexin neuronal intermediate filament protein, alpha
Synonyms: NF-66, NF66
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226180
HGNC: HGNC:6057
Homologene: 10433
Chrna1
Name: cholinergic receptor nicotinic alpha 1 subunit
Synonyms: Achr-1, Acra
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11435
HGNC: HGNC:1955
Homologene: 59
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: Dtgn1, MDC-L, D430033C21Rik, C130072N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Tbxas1
Name: thromboxane A synthase 1, platelet
Synonyms: TXS, CYP5A1, CYP5, TXAS
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21391
Homologene: 130979
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
Tas2r122
Name: taste receptor, type 2, member 122
Synonyms: Tas2r22, mGR22, T2R22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 630845
Homologene: 105455
Slc40a1
Name: solute carrier family 40 (iron-regulated transporter), member 1
Synonyms: Ol5, ferroportin1, IREG1, FPN1, metal transporting protein 1, MTP1, Slc11a3, Dusg, Pcm
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 53945
Homologene: 40959
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252910
Homologene: 74352
Ceacam3
Name: CEA cell adhesion molecule 3
Synonyms: cea12, EG384557, Psg24
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384557
HGNC: HGNC:1819
Homologene: 86971
A430078G23Rik
Name: RIKEN cDNA A430078G23 gene
Type: Gene
Species: Mouse
Chromosome: 8
Mrgpra2b
Name: MAS-related GPR, member A2B
Synonyms: MrgA2, Mrgpra2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 235712
Homologene: 79615
Mios
Name: meiosis regulator for oocyte development
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 252875
Homologene: 10371
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
St6gal2
Name: beta galactoside alpha 2,6 sialyltransferase 2
Synonyms: C230064G14Rik, ST6Gal II
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240119
Homologene: 13052
Or52p2
Name: olfactory receptor family 52 subfamily P member 2
Synonyms: GA_x6K02T2PBJ9-5307445-5306498, MOR29-1, Olfr551
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258750
Homologene: 17381
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Traf5
Name: TNF receptor-associated factor 5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22033
Homologene: 27079
9230110F15Rik
Name: RIKEN cDNA 9230110F15 gene
Synonyms:
Type: Gene
Species: Mouse
Chromosome: 9
Dlg2
Name: discs large MAGUK scaffold protein 2
Synonyms: PSD93, Chapsyn-110, B330007M19Rik, A330103J02Rik, LOC382816, Dlgh2, B230218P12Rik, Gm21505
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23859
HGNC: HGNC:2901
Homologene: 1046
Or11g7
Name: olfactory receptor family 11 subfamily G member 7
Synonyms: GA_x6K02T2PMLR-6167145-6168080, MOR106-4, Olfr740
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258661
Vmn1r192
Name: vomeronasal 1 receptor 192
Synonyms: V1ri1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 252907
Homologene: 110880
Or5an11
Name: olfactory receptor family 5 subfamily AN member 11
Synonyms: GA_x6K02T2LL2P-1028-792, GA_x6K02T057QT-4025-4642, GA_x6K02T03CT6-1-477, MOR214-3, MOR214-3, Olfr245, Olfr232, Olfr235
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258681
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Gm5150
Name: predicted gene 5150
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381484
Homologene: 129516
Slc25a10
Name: solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms: Dic
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27376
Homologene: 6519
Gm5141
Name: predicted gene 5141
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380850
Homologene: 136271
Pcdhgc5
Name: protocadherin gamma subfamily C, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93708
HGNC: HGNC:8718
Homologene: 110933
Vmn2r34
Name: vomeronasal 2, receptor 34
Synonyms: ENSMUSG00000070841
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042636
Homologene: 113703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 38,019,027 bp
  • T to A, chromosome 1 at 45,918,947 bp
  • G to A, chromosome 1 at 134,290,488 bp
  • C to T, chromosome 1 at 160,114,719 bp
  • C to G, chromosome 1 at 165,518,374 bp
  • G to A, chromosome 1 at 191,999,926 bp
  • G to T, chromosome 1 at 193,128,376 bp
  • C to A, chromosome 2 at 37,409,470 bp
  • A to T, chromosome 2 at 52,167,644 bp
  • C to T, chromosome 2 at 73,566,836 bp
  • T to A, chromosome 2 at 103,739,886 bp
  • A to T, chromosome 2 at 119,333,795 bp
  • C to T, chromosome 3 at 15,990,651 bp
  • T to C, chromosome 4 at 53,042,376 bp
  • G to A, chromosome 4 at 141,475,509 bp
  • G to A, chromosome 5 at 21,556,814 bp
  • T to A, chromosome 5 at 43,739,412 bp
  • A to T, chromosome 5 at 88,380,280 bp
  • T to C, chromosome 5 at 103,541,284 bp
  • C to A, chromosome 5 at 104,459,924 bp
  • A to G, chromosome 6 at 8,231,239 bp
  • T to A, chromosome 6 at 38,952,145 bp
  • T to A, chromosome 6 at 85,696,657 bp
  • T to A, chromosome 6 at 86,420,378 bp
  • T to A, chromosome 6 at 108,417,972 bp
  • C to T, chromosome 6 at 132,711,663 bp
  • T to A, chromosome 7 at 3,738,931 bp
  • T to A, chromosome 7 at 7,683,583 bp
  • T to C, chromosome 7 at 10,748,404 bp
  • T to C, chromosome 7 at 17,161,938 bp
  • T to A, chromosome 7 at 30,876,153 bp
  • T to A, chromosome 7 at 47,464,145 bp
  • C to A, chromosome 7 at 92,444,508 bp
  • C to T, chromosome 7 at 98,073,167 bp
  • G to A, chromosome 7 at 102,588,671 bp
  • T to A, chromosome 7 at 140,927,509 bp
  • A to T, chromosome 8 at 3,388,753 bp
  • T to A, chromosome 8 at 43,626,152 bp
  • T to C, chromosome 8 at 92,676,072 bp
  • C to T, chromosome 8 at 128,832,610 bp
  • T to A, chromosome 9 at 35,844,055 bp
  • A to T, chromosome 9 at 71,252,914 bp
  • A to G, chromosome 9 at 72,907,856 bp
  • T to A, chromosome 9 at 106,223,999 bp
  • T to A, chromosome 10 at 67,226,016 bp
  • C to T, chromosome 10 at 79,965,281 bp
  • C to A, chromosome 10 at 99,016,980 bp
  • C to T, chromosome 11 at 30,891,529 bp
  • T to A, chromosome 11 at 55,270,457 bp
  • G to A, chromosome 11 at 60,709,660 bp
  • A to T, chromosome 11 at 61,533,641 bp
  • C to T, chromosome 11 at 110,241,581 bp
  • A to T, chromosome 11 at 116,079,753 bp
  • T to C, chromosome 11 at 120,495,205 bp
  • T to C, chromosome 12 at 71,075,088 bp
  • A to T, chromosome 12 at 118,890,549 bp
  • T to A, chromosome 13 at 22,187,830 bp
  • A to T, chromosome 13 at 62,774,783 bp
  • A to T, chromosome 14 at 50,453,585 bp
  • C to T, chromosome 14 at 52,141,189 bp
  • T to C, chromosome 14 at 56,688,486 bp
  • T to G, chromosome 14 at 68,633,208 bp
  • T to C, chromosome 15 at 99,470,949 bp
  • T to A, chromosome 16 at 94,418,623 bp
  • A to G, chromosome 17 at 25,965,436 bp
  • T to A, chromosome 17 at 55,482,513 bp
  • T to A, chromosome 17 at 73,161,833 bp
  • G to A, chromosome 17 at 78,753,073 bp
  • A to G, chromosome 18 at 5,056,629 bp
  • A to C, chromosome 18 at 37,821,248 bp
  • T to C, chromosome 19 at 12,268,706 bp
  • A to T, chromosome 19 at 18,960,492 bp
  • G to A, chromosome 19 at 47,023,561 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6455 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044591-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.