Strain Name:
C57BL/6J-MtgxR6583Btlr/Mmmh
Stock Number:
044707-MU
Citation ID:
RRID:MMRRC_044707-MU
Other Names:
R6583 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, ankyrin B, Ank-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Nfib
Name: nuclear factor I/B
Synonyms: E030026I10Rik, 6720429L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18028
HGNC: HGNC:7785
Homologene: 4087
Mthfd1l
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Synonyms: Fthfsdc1, 2410004L15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270685
Homologene: 56706
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku86, Ku80
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Exoc4
Name: exocyst complex component 4
Synonyms: Sec8, Sec8l1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20336
Homologene: 40654
Tmem87a
Name: transmembrane protein 87A
Synonyms: Elkin1, A930025J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211499
Homologene: 9165
M6pr
Name: mannose-6-phosphate receptor, cation dependent
Synonyms: CD-MPR, Mpr46
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17113
HGNC: HGNC:6752
Homologene: 31086
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: Nuf2R, Cdca1, 2410003C07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66977
Homologene: 40205
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27214
Homologene: 40892
Soat1
Name: sterol O-acyltransferase 1
Synonyms: ACAT-1, hid, 8430426K15Rik, Acact
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20652
Homologene: 2333
Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms: 1110013I11Rik, 14-3-3 zeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22631
Homologene: 56528
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Cntnap5c
Name: contactin associated protein-like 5C
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 620292
VEGA: 17
Homologene: 128806
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: Rgds, RalGDS, Gnds
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Myo1c
Name: myosin IC
Synonyms: myr2, myosin-Ibeta, mm1beta, C80397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Paox
Name: polyamine oxidase (exo-N4-amino)
Synonyms: 2410012F02Rik, Pao
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212503
Homologene: 72096
Pnma8b
Name: PNMA family member 8B
Synonyms: Pnmal2, EG434128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Fggy
Name: FGGY carbohydrate kinase domain containing
Synonyms: 2310009E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75578
Homologene: 49535
Tmprss13
Name: transmembrane protease, serine 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214531
Homologene: 12936
Micu2
Name: mitochondrial calcium uptake 2
Synonyms: 4833427E09Rik, Efha1, 1110008L20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68514
VEGA: 14
Homologene: 12516
Armc12
Name: armadillo repeat containing 12
Synonyms: 4930511I11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67645
Homologene: 12168
Zfp964
Name: zinc finger protein 964
Synonyms: Gm7187
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 636741
Homologene: 130114
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Gdf7
Name: growth differentiation factor 7
Synonyms: BMP12
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238057
VEGA: 12
HGNC: HGNC:4222
Homologene: 32177
Samd11
Name: sterile alpha motif domain containing 11
Synonyms: mr-s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 231004
VEGA: 4
Homologene: 34983
Or8b49
Name: olfactory receptor family 8 subfamily B member 49
Synonyms: Olfr913, MOR165-10, MOR165-9P, GA_x6K02T2PVTD-32296575-32297513
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258225
VEGA: 9
Homologene: 79398
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 72,312,593 bp
  • C to A, chromosome 1 at 82,641,476 bp
  • T to C, chromosome 1 at 156,466,492 bp
  • T to C, chromosome 1 at 169,504,548 bp
  • G to A, chromosome 2 at 28,533,644 bp
  • A to T, chromosome 2 at 120,375,477 bp
  • A to G, chromosome 2 at 158,220,516 bp
  • A to C, chromosome 3 at 127,016,964 bp
  • T to G, chromosome 4 at 82,498,471 bp
  • T to C, chromosome 4 at 95,600,973 bp
  • A to T, chromosome 4 at 123,470,946 bp
  • T to A, chromosome 4 at 156,248,134 bp
  • A to G, chromosome 5 at 8,398,143 bp
  • T to C, chromosome 6 at 33,815,753 bp
  • A to G, chromosome 6 at 73,173,533 bp
  • T to C, chromosome 6 at 122,313,390 bp
  • A to G, chromosome 7 at 16,945,919 bp
  • T to C, chromosome 7 at 85,409,809 bp
  • T to A, chromosome 7 at 140,126,378 bp
  • G to T, chromosome 8 at 69,662,983 bp
  • G to A, chromosome 9 at 38,594,964 bp
  • G to T, chromosome 9 at 45,345,305 bp
  • A to G, chromosome 10 at 4,047,937 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • T to A, chromosome 12 at 8,301,758 bp
  • T to C, chromosome 14 at 57,943,670 bp
  • T to C, chromosome 15 at 36,790,922 bp
  • A to T, chromosome 17 at 28,538,614 bp
  • C to T, chromosome 17 at 58,330,277 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6583 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044707-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.