Strain Name:
C57BL/6J-MtgxR6597Btlr/Mmmh
Stock Number:
044721-MU
Citation ID:
RRID:MMRRC_044721-MU
Other Names:
R6597 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Pitpnc1
Name: phosphatidylinositol transfer protein, cytoplasmic 1
Synonyms: C330017I21Rik, 1110020B03Rik, RDGB-BETA, RDGBB1, 5830436L09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71795
Homologene: 138301
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, Ranbp11, 2510001A17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76582
Homologene: 7089
Rps6kc1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: RPK118, B130003F20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320119
Homologene: 8244
Stag1
Name: STAG1 cohesin complex component
Synonyms: SA-1, Scc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20842
Homologene: 21191
Slf1
Name: SMC5-SMC6 complex localization factor 1
Synonyms: 2700017A04Rik, C730024G01Rik, Brctd1, Brctx, Ankrd32
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105377
Homologene: 13000
Slc43a2
Name: solute carrier family 43, member 2
Synonyms: 7630402D21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215113
Homologene: 17555
Btg1
Name: BTG anti-proliferation factor 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12226
VEGA: 10
HGNC: HGNC:1130
Homologene: 37521
Twsg1
Name: twisted gastrulation BMP signaling modulator 1
Synonyms: D17Ertd403e, 1810013J15Rik, Tsg, 9030422N06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 65960
VEGA: 17
Homologene: 10774
Hoxd10
Name: homeobox D10
Synonyms: Hox-4.5, Hox-5.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15430
HGNC: HGNC:5133
Homologene: 1619
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: 1600002I10Rik, 60kDa, Stch, B230217N24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110920
Homologene: 5062
Xrcc4
Name: X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms: 2310057B22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108138
Homologene: 2555
Ppil1
Name: peptidylprolyl isomerase (cyclophilin)-like 1
Synonyms: Cypl1, 1110060O10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68816
HGNC: HGNC:9260
Homologene: 9367
Inava
Name: innate immunity activator
Synonyms: 5730559C18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67313
Homologene: 10103
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56715
Homologene: 8720
Atl2
Name: atlastin GTPase 2
Synonyms: 2010110I21Rik, Aip-2, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Siglech
Name: sialic acid binding Ig-like lectin H
Synonyms: Siglec-H, 6430529G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233274
Homologene: 48041
Bbs1
Name: Bardet-Biedl syndrome 1
Synonyms: D19Ertd609e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Patl2
Name: protein associated with topoisomerase II homolog 2 (yeast)
Synonyms: 4930424G05Rik, Pat1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67578
Homologene: 12155
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Or9q1
Name: olfactory receptor family 9 subfamily Q member 1
Synonyms: Olfr1500, GA_x6K02T2RE5P-4160554-4159619, MOR212-4P
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258097
Homologene: 72644
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: MOR106-6, Olfr742, GA_x6K02T2PMLR-6224293-6225228
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: 4930572H05Rik, Arhgap13
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117600
Homologene: 56898
Asb17
Name: ankyrin repeat and SOCS box-containing 17
Synonyms: 4933436O18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66772
Homologene: 12031
Cmpk2
Name: cytidine/uridine monophosphate kinase 2
Synonyms: TDKI, Tyki, 1200004E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22169
VEGA: 12
Homologene: 10748
Tpsg1
Name: tryptase gamma 1
Synonyms: TMT, Prss31
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26945
Homologene: 74994
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213234
Homologene: 11661
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 59014
Homologene: 41014
Or5d37
Name: olfactory receptor family 5 subfamily D member 37
Synonyms: GA_x6K02T2Q125-49585842-49584862, Olfr1164, MOR174-11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258634
Homologene: 74077
Gys2
Name: glycogen synthase 2
Synonyms: LGS, glycogen synthase, liver
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232493
HGNC: HGNC:4707
Homologene: 56580
Or5ac22
Name: olfactory receptor family 5 subfamily AC member 22
Synonyms: Olfr204, MOR182-3, GA_x54KRFPKG5P-55529713-55528796
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258994
Homologene: 79425
Vps36
Name: vacuolar protein sorting 36
Synonyms: 2810408E15Rik, Eap45, 2210415M20Rik, 1700010A24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70160
Homologene: 9374
Tekt3
Name: tektin 3
Synonyms: 4933407G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71062
Homologene: 12896
Ms4a13
Name: membrane-spanning 4-domains, subfamily A, member 13
Synonyms: 1700060E18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73466
Homologene: 77851
Or8b47
Name: olfactory receptor family 8 subfamily B member 47
Synonyms: GA_x6K02T2PVTD-32247224-32248163, MOR165-1, GA_x6K02T2PVTD-32223906-32224841, Olfr911, Olfr909, MOR166-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258873
VEGA: 9
Homologene: 74148
Shc3
Name: src homology 2 domain-containing transforming protein C3
Synonyms: ShcC, N-Shc, Rai
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20418
VEGA: 13
Homologene: 7536
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Rhot2
Name: ras homolog family member T2
Synonyms: Arht2, Miro2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214952
Homologene: 56038
Pla2g2e
Name: phospholipase A2, group IIE
Synonyms: mGIIEsPLA2s
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26970
Homologene: 8083
Prl3b1
Name: prolactin family 3, subfamily b, member 1
Synonyms: PL, Pl-2, Csh2, mplII, prolactin-like, mPL-II, Pl2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18776
Homologene: 7476
Fbxl8
Name: F-box and leucine-rich repeat protein 8
Synonyms: FBL8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50788
Homologene: 9279
Or55b10
Name: olfactory receptor family 55 subfamily B member 10
Synonyms: GA_x6K02T2PBJ9-5216160-5215210, S50, Olfr545, MOR42-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258837
Homologene: 17410
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: 4930485B16Rik, Gm872, LOC380653
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Spata31d1d
Name: spermatogenesis associated 31 subfamily D, member 1D
Synonyms: Fam75d1d, 4932411G14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238663
Homologene: 129932
Pcdhga7
Name: protocadherin gamma subfamily A, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93715
HGNC: HGNC:8705
Homologene: 36377
Tmppe
Name: transmembrane protein with metallophosphoesterase domain
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100504715
VEGA: 9
Homologene: 62675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 9,546,376 bp
  • G to T, chromosome 1 at 136,226,189 bp
  • A to T, chromosome 1 at 190,750,184 bp
  • G to A, chromosome 2 at 74,692,640 bp
  • A to G, chromosome 2 at 76,797,971 bp
  • A to T, chromosome 2 at 76,893,100 bp
  • A to G, chromosome 2 at 88,093,069 bp
  • G to T, chromosome 2 at 112,352,935 bp
  • T to A, chromosome 2 at 122,186,164 bp
  • T to A, chromosome 3 at 75,136,454 bp
  • A to T, chromosome 3 at 153,844,684 bp
  • T to C, chromosome 4 at 123,382,692 bp
  • T to C, chromosome 4 at 128,585,746 bp
  • T to C, chromosome 4 at 138,880,673 bp
  • G to A, chromosome 5 at 130,191,044 bp
  • A to G, chromosome 6 at 121,648,121 bp
  • T to A, chromosome 6 at 142,456,309 bp
  • A to T, chromosome 7 at 55,768,463 bp
  • A to T, chromosome 7 at 102,494,421 bp
  • A to G, chromosome 8 at 22,202,304 bp
  • A to C, chromosome 8 at 105,268,891 bp
  • T to A, chromosome 9 at 20,348,001 bp
  • A to T, chromosome 9 at 38,524,004 bp
  • G to A, chromosome 9 at 100,887,420 bp
  • A to T, chromosome 9 at 114,405,244 bp
  • T to C, chromosome 10 at 92,999,040 bp
  • T to A, chromosome 10 at 96,618,320 bp
  • T to C, chromosome 10 at 121,792,371 bp
  • A to G, chromosome 11 at 63,081,259 bp
  • G to A, chromosome 11 at 75,571,855 bp
  • G to T, chromosome 11 at 107,226,232 bp
  • G to T, chromosome 12 at 26,474,145 bp
  • A to G, chromosome 12 at 119,173,398 bp
  • T to A, chromosome 13 at 14,316,818 bp
  • G to A, chromosome 13 at 27,247,974 bp
  • T to A, chromosome 13 at 51,442,973 bp
  • C to A, chromosome 13 at 59,726,057 bp
  • A to G, chromosome 13 at 77,049,129 bp
  • A to T, chromosome 13 at 90,000,929 bp
  • A to G, chromosome 13 at 106,865,863 bp
  • T to A, chromosome 14 at 50,515,551 bp
  • T to A, chromosome 16 at 34,182,747 bp
  • C to T, chromosome 16 at 59,315,350 bp
  • A to T, chromosome 16 at 75,765,197 bp
  • A to G, chromosome 17 at 19,694,188 bp
  • G to A, chromosome 17 at 25,369,297 bp
  • A to T, chromosome 17 at 25,840,912 bp
  • C to A, chromosome 17 at 29,261,878 bp
  • C to A, chromosome 17 at 65,937,804 bp
  • T to A, chromosome 17 at 79,852,766 bp
  • T to C, chromosome 18 at 37,717,006 bp
  • T to A, chromosome 19 at 4,899,306 bp
  • T to C, chromosome 19 at 11,192,939 bp
  • T to A, chromosome 19 at 13,828,457 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6597 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044721-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.