Strain Name:
C57BL/6J-MtgxR6608Btlr/Mmmh
Stock Number:
044731-MU
Citation ID:
RRID:MMRRC_044731-MU
Other Names:
R6608 (G1)
Major Collection:

Strain Information

Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 2700038M07Rik, 1110056B13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78889
Homologene: 9218
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, 5730505K17Rik, Casc5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76464
Homologene: 44890
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109331
Homologene: 5571
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, D630048A14Rik, Ki67
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: Uchrp, 2610014N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22224
Homologene: 31294
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74213
Homologene: 41468
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, 1A1, Klkbp, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Cdan1
Name: codanin 1
Synonyms: CDA-I, CDA1, 1500015A01Rik, codanin-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68968
HGNC: HGNC:1713
Homologene: 16324
Adgrg5
Name: adhesion G protein-coupled receptor G5
Synonyms: LOC382045, PGR27, Gpr114
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382045
Homologene: 17828
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Parp11
Name: poly (ADP-ribose) polymerase family, member 11
Synonyms: HIN1L, 5330431N24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101187
HGNC: HGNC:1186
Homologene: 10680
Tinagl1
Name: tubulointerstitial nephritis antigen-like 1
Synonyms: 1110021J17Rik, androgen-regulated gene 1, Arg1, Lcn7, AZ-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 94242
Homologene: 41472
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: RdgB, DRES9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71985
Homologene: 49825
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Decr2
Name: 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26378
HGNC: HGNC:2754
Homologene: 22223
Pcdhb5
Name: protocadherin beta 5
Synonyms: Pcdhb4A, PcdhbE
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Stard7
Name: StAR related lipid transfer domain containing 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99138
Homologene: 32463
Or5d40
Name: olfactory receptor family 5 subfamily D member 40
Synonyms: GA_x6K02T2Q125-49669483-49670421, MOR174-13, Olfr1168
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258524
Homologene: 128091
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: B0AT1, 4632401C08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74338
Homologene: 52819
Adamts18
Name: ADAM metallopeptidase with thrombospondin type 1 motif 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 208936
Homologene: 65241
Clns1a
Name: chloride channel, nucleotide-sensitive, 1A
Synonyms: ICLN, Clci, Clcni, 2610100O04Rik, 2610036D06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12729
HGNC: HGNC:2080
Homologene: 990
Or2n1c
Name: olfactory receptor family 2 subfamily N member 1C
Synonyms: GA_x6K02T2PSCP-2656648-2657586, MOR256-48, Olfr135
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258329
Homologene: 110603
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237926
Homologene: 41252
Or6n2
Name: olfactory receptor family 6 subfamily N member 2
Synonyms: GA_x6K02T2P20D-21108443-21107490, MOR105-5P, Olfr430
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258713
Homologene: 17362
Irag1
Name: inositol 1,4,5-triphosphate receptor associated 1
Synonyms: Ris1, Mrvi1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17540
HGNC: HGNC:7237
Homologene: 4425
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Coq6
Name: coenzyme Q6 monooxygenase
Synonyms: 5930427M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217707
Homologene: 6039
Ankrd37
Name: ankyrin repeat domain 37
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 654824
Homologene: 35347
Or3a1b
Name: olfactory receptor family 3 subfamily A member 1B
Synonyms: GA_x6K02T2P1NL-4278037-4278984, MOR255-6, Olfr401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258701
HGNC: HGNC:8282
Homologene: 73922
AK157302
Name: cDNA sequence AK157302
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432732
Dmgdh
Name: dimethylglycine dehydrogenase precursor
Synonyms: 1200014D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74129
Homologene: 8372
Man1b1
Name: mannosidase, alpha, class 1B, member 1
Synonyms: LOC227619, MANA-ER, E430019H13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227619
HGNC: HGNC:6823
Homologene: 5230
Epm2a
Name: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
Synonyms: laforin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13853
HGNC: HGNC:3413
Homologene: 38087
Gm1979
Name: predicted gene 1979
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100038949
Homologene: 69402
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,525,118 bp
  • T to C, chromosome 1 at 58,057,546 bp
  • A to G, chromosome 1 at 174,069,729 bp
  • T to A, chromosome 2 at 25,343,251 bp
  • G to A, chromosome 2 at 76,749,329 bp
  • A to G, chromosome 2 at 88,185,705 bp
  • A to G, chromosome 2 at 119,086,612 bp
  • A to C, chromosome 2 at 120,726,680 bp
  • A to T, chromosome 2 at 127,290,795 bp
  • C to T, chromosome 4 at 49,650,051 bp
  • A to G, chromosome 4 at 130,172,989 bp
  • T to A, chromosome 5 at 26,001,096 bp
  • T to C, chromosome 5 at 121,632,492 bp
  • A to G, chromosome 6 at 127,477,848 bp
  • A to G, chromosome 7 at 97,716,468 bp
  • A to T, chromosome 7 at 110,888,551 bp
  • G to A, chromosome 7 at 135,698,361 bp
  • C to T, chromosome 8 at 45,999,854 bp
  • T to C, chromosome 8 at 94,941,720 bp
  • A to T, chromosome 8 at 113,775,279 bp
  • C to T, chromosome 8 at 119,948,422 bp
  • C to A, chromosome 9 at 20,774,019 bp
  • G to T, chromosome 9 at 21,108,016 bp
  • T to C, chromosome 10 at 11,390,987 bp
  • C to T, chromosome 10 at 77,112,794 bp
  • T to A, chromosome 11 at 72,912,826 bp
  • T to C, chromosome 11 at 74,121,628 bp
  • C to T, chromosome 11 at 79,240,362 bp
  • T to C, chromosome 11 at 94,542,609 bp
  • G to A, chromosome 12 at 84,372,148 bp
  • C to G, chromosome 12 at 85,015,277 bp
  • A to T, chromosome 12 at 104,149,624 bp
  • T to C, chromosome 13 at 21,495,624 bp
  • A to G, chromosome 13 at 73,683,972 bp
  • G to A, chromosome 13 at 93,706,744 bp
  • A to G, chromosome 13 at 96,832,780 bp
  • T to A, chromosome 14 at 105,152,498 bp
  • A to G, chromosome 16 at 14,132,714 bp
  • C to T, chromosome 17 at 26,083,884 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to C, chromosome 17 at 38,208,479 bp
  • A to G, chromosome 18 at 37,321,823 bp
  • A to G, chromosome 19 at 4,110,875 bp
  • C to T, chromosome 19 at 10,918,980 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6608 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044731-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.