Strain Name:
C57BL/6J-MtgxR6619Btlr/Mmmh
Stock Number:
044742-MU
Citation ID:
RRID:MMRRC_044742-MU
Other Names:
R6619 (G1)
Major Collection:

Strain Information

Sp4
Name: trans-acting transcription factor 4
Synonyms: HF-1b, HF1-b, 5730497N03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20688
VEGA: 12
Homologene: 2341
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: jumonji, Jmj
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Mast2
Name: microtubule associated serine/threonine kinase 2
Synonyms: Mtssk, MAST205
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17776
Homologene: 7428
Trim36
Name: tripartite motif-containing 36
Synonyms: Haprin, D18Wsu100e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 28105
VEGA: 18
Homologene: 10275
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: rjs, D7H15F37S1, D15F32S1h, D7H15F32S1, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Atp13a5
Name: ATPase type 13A5
Synonyms: C630015F21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268878
Homologene: 77451
Obi1
Name: ORC ubiquitin ligase 1
Synonyms: 2610206B13Rik, Rnf219, 2810449K13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72486
VEGA: 14
Homologene: 11578
Tepsin
Name: TEPSIN, adaptor related protein complex 4 accessory protein
Synonyms: Enthd2, 2410002I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78777
Homologene: 35359
Phf13
Name: PHD finger protein 13
Synonyms: SPOC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230936
Homologene: 17822
Rpgrip1l
Name: Rpgrip1-like
Synonyms: fantom, Ftm, Nphp8, 1700047E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244585
Homologene: 18296
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b1565Clo, b2b3491Clo, Mdnah5, b2b1154Clo, b2b1537Clo, Dnahc5, b2b1134Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Zfp418
Name: zinc finger protein 418
Synonyms: A230102I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232854
Homologene: 119890
Rab19
Name: RAB19, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19331
Homologene: 22623
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Strc
Name: stereocilin
Synonyms: DFNB16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140476
Homologene: 15401
Skint3
Name: selection and upkeep of intraepithelial T cells 3
Synonyms: A430090E18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195564
Baiap2l1
Name: BAI1-associated protein 2-like 1
Synonyms: 1300006M19Rik, IRTKS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66898
Homologene: 23123
P2ry14
Name: purinergic receptor P2Y, G-protein coupled, 14
Synonyms: Gpr105, P2Y14, A330108O13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 140795
Homologene: 15769
Or8k38
Name: olfactory receptor family 8 subfamily K member 38
Synonyms: Olfr1085, MOR191-1, GA_x6K02T2Q125-48147264-48146323
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258583
Serpina3m
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3M
Synonyms: Spi-2rs1, contrapsin-like, 3e46, MMCM7, alpha-1 antiproteinase, Spi2-rs1, Spi2.4, MMSPi2.4, antitrypsin, Spi-2l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20717
HGNC: HGNC:16
Homologene: 111129
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: fg, enr, BPFD#36, froggy
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: 4632412N22Rik, Fam179a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Frk
Name: fyn-related kinase
Synonyms: GTK, BSK/IYK
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14302
VEGA: 10
HGNC: HGNC:3955
Homologene: 48065
Lancl2
Name: LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms: 1700003F10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71835
HGNC: HGNC:6509
Homologene: 23116
Or4z4
Name: olfactory receptor family 4 subfamily Z member 4
Synonyms: MOR239-4, Olfr1427, GA_x6K02T2RE5P-2458473-2457538
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258674
Homologene: 128080
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216961
Homologene: 104099
Crocc2
Name: ciliary rootlet coiled-coil, rootletin family member 2
Synonyms: E030010N08Rik, LOC381284
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381284
Homologene: 141152
Or5ak23
Name: olfactory receptor family 5 subfamily AK member 23
Synonyms: MOR203-2, GA_x6K02T2Q125-46891524-46890580, Olfr993
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258427
Homologene: 79352
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: 6330417G04Rik, Grf2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Or6c38
Name: olfactory receptor family 6 subfamily C member 38
Synonyms: GA_x6K02T2PULF-10779441-10778503, MOR114-4, Olfr768
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258863
Homologene: 17159
Reep1
Name: receptor accessory protein 1
Synonyms: D6Ertd253e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52250
Homologene: 41504
Pcdhga6
Name: protocadherin gamma subfamily A, 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93714
HGNC: HGNC:8704
Homologene: 129611
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Dhrs7l
Name: dehydrogenase/reductase 7 like 1
Synonyms: Gm4756
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209183
Homologene: 134116
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,190,501 bp
  • T to A, chromosome 2 at 14,294,786 bp
  • T to C, chromosome 2 at 85,414,081 bp
  • T to C, chromosome 2 at 86,658,062 bp
  • A to T, chromosome 2 at 121,247,499 bp
  • A to G, chromosome 2 at 121,368,432 bp
  • T to C, chromosome 3 at 59,115,733 bp
  • T to C, chromosome 4 at 112,253,864 bp
  • C to A, chromosome 4 at 116,316,497 bp
  • T to A, chromosome 4 at 151,991,657 bp
  • T to C, chromosome 5 at 144,286,106 bp
  • T to A, chromosome 6 at 39,388,126 bp
  • C to A, chromosome 6 at 57,722,581 bp
  • T to C, chromosome 6 at 71,807,842 bp
  • G to A, chromosome 7 at 7,181,896 bp
  • A to T, chromosome 7 at 56,068,092 bp
  • G to A, chromosome 8 at 72,883,264 bp
  • C to T, chromosome 8 at 91,232,871 bp
  • A to G, chromosome 10 at 34,605,839 bp
  • A to T, chromosome 10 at 129,093,454 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • T to C, chromosome 11 at 74,932,453 bp
  • A to G, chromosome 11 at 77,466,204 bp
  • C to T, chromosome 11 at 120,095,602 bp
  • A to T, chromosome 12 at 72,621,950 bp
  • A to T, chromosome 12 at 104,391,507 bp
  • G to A, chromosome 12 at 118,299,342 bp
  • A to G, chromosome 13 at 44,874,396 bp
  • A to T, chromosome 13 at 92,028,519 bp
  • T to C, chromosome 14 at 104,522,557 bp
  • C to A, chromosome 15 at 28,409,120 bp
  • G to A, chromosome 16 at 29,349,015 bp
  • A to G, chromosome 17 at 71,689,271 bp
  • T to A, chromosome 18 at 20,032,278 bp
  • T to A, chromosome 18 at 37,709,649 bp
  • T to A, chromosome 18 at 37,721,684 bp
  • T to C, chromosome 18 at 46,188,408 bp
  • A to G, chromosome 19 at 12,099,363 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6619 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044742-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.