Strain Name:
C57BL/6J-MtgxR6645Btlr/Mmmh
Stock Number:
044766-MU
Citation ID:
RRID:MMRRC_044766-MU
Other Names:
R6645 (G1)
Major Collection:

Strain Information

Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: Rbp1l1, 6330417L24Rik, RBBP1L1, 6720480E17Rik, SAP180, BRCAA1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Tbce
Name: tubulin-specific chaperone E
Synonyms: 2610206D02Rik, C530005D02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70430
Homologene: 37744
Fam53a
Name: family with sequence similarity 53, member A
Synonyms: 5430419M09Rik, DNTNP, 2410018C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74504
Homologene: 18660
Lrrc2
Name: leucine rich repeat containing 2
Synonyms: 4933431K03Rik, 2400002D05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74249
Homologene: 23454
Washc4
Name: WASH complex subunit 4
Synonyms: A230046K03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 319277
VEGA: 10
Homologene: 123926
Ddx4
Name: DEAD box helicase 4
Synonyms: VASA, mvh / m'vasa, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: Wwp4, 1110067P07Rik, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Anp32e
Name: acidic nuclear phosphoprotein 32 family member E
Synonyms: CPD1, LANP-L, 2810018A15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66471
Homologene: 41519
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: 2610042O15Rik, C86341, Mms19, Mms19l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72199
Homologene: 41480
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Srsf10
Name: serine and arginine-rich splicing factor 10
Synonyms: TASR1, FUSIP2, SRrp40, NSSR1, NSSR2, Sfrs13a, Srsf13a, TASR2, Nssr, Fusip1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14105
Homologene: 134051
Atxn10
Name: ataxin 10
Synonyms: Sca10, Tex169, E46, TEG-169
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Mfn2
Name: mitofusin 2
Synonyms: hypertension related protein 1, D630023P19Rik, Fzo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170731
Homologene: 8915
Prom1
Name: prominin 1
Synonyms: Prom-1, Prom, AC133, 4932416E19Rik, CD133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212712
Homologene: 32249
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: Coh1, 2310042E16Rik, 1810042B05Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Slitrk3
Name: SLIT and NTRK-like family, member 3
Synonyms: ST3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 386750
Homologene: 8955
Arap1
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms: 2410002L19Rik, Centd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69710
Homologene: 12326
Ndfip2
Name: Nedd4 family interacting protein 2
Synonyms: 0710001O20Rik, 9130207N19Rik, N4wbp5a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76273
Homologene: 12636
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Cilp
Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms: C130036G17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214425
HGNC: HGNC:1980
Homologene: 2679
Oca2
Name: oculocutaneous albinism II
Synonyms: D7H15S12, D7H15S12, p
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18431
HGNC: HGNC:8101
Homologene: 37281
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Spata31e2
Name: spermatogenesis associated 31 subfamily E member 2
Synonyms: 4931408C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210940
Homologene: 86827
Or8g35
Name: olfactory receptor family 8 subfamily G member 35
Synonyms: MOR171-34, MOR171-50, GA_x6K02T2PVTD-33167297-33166353, Olfr955
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258242
VEGA: 9
Homologene: 133698
Tdrd6
Name: tudor domain containing 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210510
Homologene: 19364
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Slc13a4
Name: solute carrier family 13 (sodium/sulfate symporters), member 4
Synonyms: SUT1, SUT-1, 9630060C05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243755
Homologene: 69125
Ttc21b
Name: tetratricopeptide repeat domain 21B
Synonyms: Thm1, 2410066K11Rik, line 158, aln
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73668
Homologene: 57006
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Slc9a3
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3
Synonyms: 9030624O13Rik, NHE3, NHE-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105243
VEGA: 13
Homologene: 55804
Cep85l
Name: centrosomal protein 85-like
Synonyms: Gm9766
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100038725
VEGA: 10
Homologene: 52598
Ppef2
Name: protein phosphatase, EF hand calcium-binding domain 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19023
HGNC: HGNC:9244
Homologene: 55959
Notch4
Name: notch 4
Synonyms: Int-3, N4, Int3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Ccdc170
Name: coiled-coil domain containing 170
Synonyms: Gm221, LOC237250
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100504234
Homologene: 69393
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Zmat4
Name: zinc finger, matrin type 4
Synonyms: 9630048M01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320158
Homologene: 81899
Pde7b
Name: phosphodiesterase 7B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 29863
HGNC: HGNC:8792
Homologene: 32194
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384221
Homologene: 104825
Dph7
Name: diphthamine biosynethesis 7
Synonyms: Wdr85, 2810443J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67228
Homologene: 5432
Jph1
Name: junctophilin 1
Synonyms: mitsugumin72, JP-1, ENSMUSG00000054314
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57339
Homologene: 10761
Kbtbd8
Name: kelch repeat and BTB (POZ) domain containing 8
Synonyms: SSEC-51, SSEC51, SSEC 51, Takrp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243574
Homologene: 13043
Or8b43
Name: olfactory receptor family 8 subfamily B member 43
Synonyms: Olfr902, MOR169-1, GA_x6K02T2PVTD-32141623-32142552
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258798
VEGA: 9
Sgpp2
Name: sphingosine-1-phosphate phosphatase 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433323
Homologene: 51848
Sptssa
Name: serine palmitoyltransferase, small subunit A
Synonyms: 1110002B05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104725
VEGA: 12
Homologene: 15889
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 17,091,761 bp
  • T to A, chromosome 1 at 26,683,117 bp
  • T to C, chromosome 1 at 56,797,007 bp
  • C to T, chromosome 1 at 78,360,162 bp
  • A to T, chromosome 1 at 175,614,876 bp
  • T to C, chromosome 1 at 188,523,331 bp
  • T to C, chromosome 2 at 24,965,651 bp
  • T to C, chromosome 2 at 66,236,377 bp
  • T to A, chromosome 2 at 180,179,670 bp
  • A to T, chromosome 3 at 64,556,876 bp
  • G to T, chromosome 3 at 73,049,861 bp
  • T to A, chromosome 3 at 95,937,102 bp
  • T to C, chromosome 4 at 112,892,038 bp
  • T to C, chromosome 4 at 135,863,563 bp
  • T to A, chromosome 4 at 147,894,612 bp
  • G to T, chromosome 5 at 33,600,784 bp
  • A to T, chromosome 5 at 44,047,514 bp
  • T to C, chromosome 5 at 92,230,461 bp
  • T to A, chromosome 5 at 108,138,930 bp
  • A to T, chromosome 5 at 109,428,381 bp
  • G to T, chromosome 6 at 35,268,839 bp
  • T to C, chromosome 6 at 41,617,272 bp
  • C to T, chromosome 6 at 95,126,749 bp
  • G to T, chromosome 7 at 56,314,774 bp
  • A to G, chromosome 7 at 101,408,111 bp
  • G to A, chromosome 8 at 23,797,401 bp
  • T to C, chromosome 9 at 38,448,923 bp
  • T to A, chromosome 9 at 39,470,266 bp
  • A to T, chromosome 9 at 65,279,305 bp
  • G to A, chromosome 9 at 70,803,748 bp
  • T to C, chromosome 9 at 110,970,107 bp
  • A to G, chromosome 10 at 4,560,974 bp
  • C to A, chromosome 10 at 20,610,566 bp
  • C to T, chromosome 10 at 53,301,672 bp
  • C to T, chromosome 10 at 83,572,195 bp
  • C to T, chromosome 11 at 59,085,262 bp
  • A to G, chromosome 11 at 60,477,292 bp
  • G to T, chromosome 12 at 16,698,579 bp
  • T to C, chromosome 12 at 54,646,490 bp
  • A to G, chromosome 12 at 65,106,100 bp
  • T to C, chromosome 13 at 14,005,229 bp
  • A to T, chromosome 13 at 14,120,152 bp
  • T to A, chromosome 13 at 74,164,172 bp
  • A to G, chromosome 13 at 112,641,174 bp
  • G to A, chromosome 14 at 30,570,211 bp
  • T to A, chromosome 14 at 105,292,273 bp
  • A to G, chromosome 15 at 35,910,305 bp
  • A to G, chromosome 15 at 38,029,506 bp
  • G to T, chromosome 15 at 85,376,703 bp
  • T to C, chromosome 16 at 45,690,963 bp
  • A to G, chromosome 17 at 34,587,816 bp
  • A to G, chromosome 17 at 43,624,532 bp
  • A to T, chromosome 18 at 7,973,523 bp
  • G to C, chromosome 19 at 41,955,191 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6645 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044766-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.