Strain Name:
C57BL/6J-MtgxR6696Btlr/Mmmh
Stock Number:
044814-MU
Citation ID:
RRID:MMRRC_044814-MU
Other Names:
R6696 (G1)
Major Collection:

Strain Information

Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Epha2
Name: Eph receptor A2
Synonyms: Myk2, Eck, Sek2, Sek-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13836
HGNC: HGNC:3386
Homologene: 20929
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: EG406236, Prkwnk1, 6430573H23Rik, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Slc7a7
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Synonyms: my+lat1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20540
Homologene: 88701
Prep
Name: prolyl endopeptidase
Synonyms: Pop, prolyl oligopeptidase, D10Wsu136e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
Srbd1
Name: S1 RNA binding domain 1
Synonyms: D530025C17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78586
VEGA: 17
Homologene: 9994
Wdr7
Name: WD repeat domain 7
Synonyms: TGF-beta resistance associated gene, TRAG
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Mms19
Name: MMS19 cytosolic iron-sulfur assembly component
Synonyms: C86341, Mms19l, 2610042O15Rik, Mms19
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72199
Homologene: 41480
Slc18a3
Name: solute carrier family 18 (vesicular monoamine), member 3
Synonyms: VAChT, VAT
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20508
Homologene: 11022
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Eipr1
Name: EARP complex and GARP complex interacting protein 1
Synonyms: D12Ertd604e, Tssc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380752
VEGA: 12
Homologene: 2481
Slc5a2
Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms: Sglt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246787
Homologene: 2289
Mns1
Name: meiosis-specific nuclear structural protein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17427
Homologene: 40628
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Fbxw18
Name: F-box and WD-40 domain protein 18
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546161
Homologene: 110776
Hivep2
Name: human immunodeficiency virus type I enhancer binding protein 2
Synonyms: MIBP1, Gm20114, Schnurri-2, Shn-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15273
HGNC: HGNC:4921
Homologene: 4900
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: E430002F06Rik, A430075I06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231050
Homologene: 11126
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: Megf7, mdig, 6430526J12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Gata3
Name: GATA binding protein 3
Synonyms: Gata-3, jal
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14462
HGNC: HGNC:4172
Homologene: 1550
Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
Synonyms: A330045H12Rik, LOC231597
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 403178
Homologene: 138628
Hltf
Name: helicase-like transcription factor
Synonyms: Smarca3, Snf2l3, P113
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20585
Homologene: 30136
Myo1c
Name: myosin IC
Synonyms: myr2, C80397, mm1beta, myosin-Ibeta
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Ccdc134
Name: coiled-coil domain containing 134
Synonyms: 2310042L06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76457
VEGA: 15
Homologene: 77543
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Tgfbr3
Name: transforming growth factor, beta receptor III
Synonyms: 1110036H20Rik, betaglycan, TBRIII
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21814
Homologene: 2436
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Vmn2r7
Name: vomeronasal 2, receptor 7
Synonyms: 4933425M15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319217
Homologene: 129754
Tmem67
Name: transmembrane protein 67
Synonyms: b2b1163.1Clo, 5330408M12Rik, b2b1291.1Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329795
Homologene: 71886
Lrrc25
Name: leucine rich repeat containing 25
Synonyms: Mapa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211228
Homologene: 51663
Nme3
Name: NME/NM23 nucleoside diphosphate kinase 3
Synonyms: Ndk3, non-metastatic cells 3, protein expressed in, 1810009F08Rik, Nm23-M3, DR-nm23
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 79059
HGNC: HGNC:7851
Homologene: 20562
Iqca1
Name: IQ motif containing with AAA domain 1
Synonyms: Iqca, 4930585L22Rik, 4930465P12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74918
Homologene: 49784
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252910
Homologene: 74352
Arhgap25
Name: Rho GTPase activating protein 25
Synonyms: A130039I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232201
Homologene: 45507
Klra6
Name: killer cell lectin-like receptor, subfamily A, member 6
Synonyms: Ly49f, Ly49F
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16637
Homologene: 110821
Atg3
Name: autophagy related 3
Synonyms: PC3-96, Apg3l, APG3, 2610016C12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67841
Homologene: 6836
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: 9130206P09Rik, D6Ertd32e, GAF1, RIP11
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52055
Homologene: 9158
Coasy
Name: Coenzyme A synthase
Synonyms: Ukr1, 1300003G02Rik, Dpck, Ppat
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71743
Homologene: 11889
Tmem191
Name: transmembrane protein 191
Synonyms: MNCb-4137, D16Bwg1494e, 4933405M22Rik, Tmem191c
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224019
Homologene: 131221
Best2
Name: bestrophin 2
Synonyms: Vmd2l1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212989
Homologene: 41187
Gm527
Name: predicted gene 527
Synonyms: LOC217648
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217648
VEGA: 12
Homologene: 19024
Imp4
Name: IMP4, U3 small nucleolar ribonucleoprotein
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27993
Homologene: 68891
Lnp1
Name: leukemia NUP98 fusion partner 1
Synonyms: Gm19797
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100503609
Homologene: 67109
Dhrs7l
Name: dehydrogenase/reductase 7 like 1
Synonyms: Gm4756
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 209183
Homologene: 134116
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,444,246 bp
  • G to A, chromosome 1 at 90,130,200 bp
  • T to A, chromosome 1 at 97,885,727 bp
  • A to T, chromosome 2 at 9,874,492 bp
  • A to G, chromosome 2 at 91,497,345 bp
  • T to G, chromosome 3 at 20,065,306 bp
  • A to T, chromosome 3 at 64,707,074 bp
  • C to A, chromosome 4 at 12,061,754 bp
  • T to A, chromosome 4 at 123,509,803 bp
  • A to G, chromosome 4 at 141,321,539 bp
  • T to C, chromosome 5 at 25,255,114 bp
  • C to T, chromosome 5 at 107,136,930 bp
  • A to G, chromosome 5 at 110,101,885 bp
  • T to C, chromosome 6 at 85,341,946 bp
  • G to T, chromosome 6 at 87,465,651 bp
  • C to A, chromosome 6 at 87,466,563 bp
  • A to G, chromosome 6 at 119,948,282 bp
  • A to G, chromosome 6 at 130,016,733 bp
  • T to A, chromosome 7 at 10,748,474 bp
  • A to T, chromosome 7 at 64,350,078 bp
  • T to A, chromosome 7 at 110,560,298 bp
  • A to T, chromosome 7 at 128,270,043 bp
  • A to G, chromosome 8 at 4,739,262 bp
  • G to A, chromosome 8 at 70,618,365 bp
  • A to T, chromosome 8 at 85,011,244 bp
  • C to T, chromosome 9 at 20,779,033 bp
  • G to A, chromosome 9 at 72,452,762 bp
  • A to C, chromosome 9 at 109,688,764 bp
  • T to C, chromosome 10 at 14,133,759 bp
  • A to T, chromosome 10 at 45,153,078 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • G to T, chromosome 11 at 101,083,101 bp
  • C to T, chromosome 11 at 115,791,988 bp
  • C to A, chromosome 12 at 28,859,358 bp
  • T to C, chromosome 12 at 64,921,092 bp
  • C to T, chromosome 12 at 72,619,481 bp
  • T to C, chromosome 14 at 32,464,313 bp
  • C to T, chromosome 14 at 54,377,761 bp
  • T to A, chromosome 15 at 82,131,521 bp
  • C to T, chromosome 16 at 17,283,022 bp
  • A to T, chromosome 16 at 45,175,281 bp
  • T to C, chromosome 16 at 56,927,786 bp
  • C to G, chromosome 16 at 90,960,452 bp
  • G to T, chromosome 17 at 24,897,294 bp
  • C to T, chromosome 17 at 86,139,191 bp
  • A to G, chromosome 18 at 63,739,330 bp
  • C to A, chromosome 19 at 41,954,013 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6696 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044814-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.