Strain Name:
C57BL/6J-MtgxR6738Btlr/Mmmh
Stock Number:
044856-MU
Citation ID:
RRID:MMRRC_044856-MU
Other Names:
R6738 (G1)
Major Collection:

Strain Information

Tln2
Name: talin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70549
VEGA: 9
Homologene: 56692
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, D230004K18Rik, Gp330, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Tex21
Name: testis expressed gene 21
Synonyms: 4931406F04Rik, tsec-2, 4931412D23Rik, 4931421K24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80384
VEGA: 12
Homologene: 10510
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: Cyp11b, Cyp11b-2, steroid-11-beta-hydroxylase, aldosterone synthase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Bclaf1
Name: BCL2-associated transcription factor 1
Synonyms: 2700025J07Rik, 2610102K23Rik, 5730534O06Rik, 2810454G14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72567
Homologene: 8832
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Prkd2
Name: protein kinase D2
Synonyms: PKD2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101540
Homologene: 9516
Sfswap
Name: splicing factor SWAP
Synonyms: 6330437E22Rik, Sfrs8, 1190005N23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231769
Homologene: 134548
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, Yod, 3010027A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Ythdf2
Name: YTH N6-methyladenosine RNA binding protein 2
Synonyms: HGRG8, NY-REN-2, 9430020E02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213541
Homologene: 32302
Tfap4
Name: transcription factor AP4
Synonyms: AP-4, D930048N17Rik, Tcfap4, bHLHc41
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 83383
VEGA: 16
Homologene: 2424
Fam193b
Name: family with sequence similarity 193, member B
Synonyms: IRIZIO
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212483
VEGA: 13
Homologene: 130095
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: E430008G22Rik, c-Abl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Dlx2
Name: distal-less homeobox 2
Synonyms: DII A, Dlx-2, Tes-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13392
HGNC: HGNC:2915
Homologene: 3244
Ppp2r1a
Name: protein phosphatase 2, regulatory subunit A, alpha
Synonyms: PR65, 6330556D22Rik, protein phosphatase PP2A, PP2A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 51792
HGNC: HGNC:9302
Homologene: 68559
Mnat1
Name: menage a trois 1
Synonyms: MAT1, E130115E11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17420
HGNC: HGNC:7181
Homologene: 1821
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, Garnl1, Tulip1, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, 2300002E22Rik, DP, rul
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKKbeta, IKK[b], IKK-beta, IKK2, IKK-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Ric3
Name: RIC3 acetylcholine receptor chaperone
Synonyms: E130307J04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320360
Homologene: 49772
Amigo2
Name: adhesion molecule with Ig like domain 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105827
VEGA: 15
Homologene: 18649
Esyt3
Name: extended synaptotagmin-like protein 3
Synonyms: Fam62c, D9Ertd280e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272636
Homologene: 18626
Cd24a
Name: CD24a antigen
Synonyms: HSA, cluster of differentiation 24, Ly-52, heat stable antigen, nectadrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12484
VEGA: 10
HGNC: HGNC:1645
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: D430029O09Rik, Polydom, 4833413O10Rik, 1110021D17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Ccdc73
Name: coiled-coil domain containing 73
Synonyms: 2210415I11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211936
Homologene: 52235
Krt35
Name: keratin 35
Synonyms: Krt1-24, Ha5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Mab21l4
Name: mab-21-like 4
Synonyms: 2310007B03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71874
Homologene: 11761
Siah2
Name: siah E3 ubiquitin protein ligase 2
Synonyms: Sinh2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20439
Homologene: 21053
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: Gabrb-2, C030002O17Rik, C030021G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Or1j18
Name: olfactory receptor family 1 subfamily J member 18
Synonyms: MOR136-9, GA_x6K02T2NLDC-33428755-33429693, Olfr347
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258945
Homologene: 51790
Krt76
Name: keratin 76
Synonyms: 2310001L23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77055
Homologene: 22931
Myom1
Name: myomesin 1
Synonyms: skelemin, D430047A17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Col11a1
Name: collagen, type XI, alpha 1
Synonyms: C530001D20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12814
HGNC: HGNC:2186
Homologene: 56389
Ntn5
Name: netrin 5
Synonyms: LOC243967
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243967
Homologene: 17106
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: Olfr961, GA_x6K02T2PVTD-33343617-33344561, MOR224-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Slc23a2
Name: solute carrier family 23 (nucleobase transporters), member 2
Synonyms: Slc23a1, SVCT2, YSPL3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54338
Homologene: 68440
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: OKB1, OCT6, CT2, 4921504E14Rik, FLIPT2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70840
Homologene: 41957
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627814
Homologene: 129678
Otop2
Name: otopetrin 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237987
Homologene: 27803
Il18r1
Name: interleukin 18 receptor 1
Synonyms: Il18ralpha, Il1rrp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16182
HGNC: HGNC:5988
Homologene: 2861
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: 6330406L22Rik, Hmha1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70719
Homologene: 69120
Ncoa4
Name: nuclear receptor coactivator 4
Synonyms: 1110034E15Rik, 4432406M01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27057
HGNC: HGNC:7671
Homologene: 38052
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: UTI, ASPI, Intin4, ulinastatin, Urinary Trypsin Inhibitor, HI-30, Itil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Mptx2
Name: mucosal pentraxin 2
Synonyms: Gm11062
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100504232
Homologene: 134535
Abat
Name: 4-aminobutyrate aminotransferase
Synonyms: GABA-T, 9630038C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268860
HGNC: HGNC:23
Homologene: 542
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: Gm9813, LOC217602, EG639426, AU024163, 4921506M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Naaladl2
Name: N-acetylated alpha-linked acidic dipeptidase-like 2
Synonyms: EG635702, LOC381500, 2810043G22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 635702
Homologene: 45786
H2al2a
Name: H2A histone family member L2A
Synonyms: 1700113O17Rik, H2afb1, H2AL2, Tseg1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68231
Homologene: 83326
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 40,498,656 bp
  • G to A, chromosome 1 at 93,159,985 bp
  • T to C, chromosome 1 at 173,274,855 bp
  • G to T, chromosome 2 at 17,996,618 bp
  • T to C, chromosome 2 at 31,794,574 bp
  • C to T, chromosome 2 at 36,734,432 bp
  • T to A, chromosome 2 at 69,458,488 bp
  • A to G, chromosome 2 at 71,546,062 bp
  • T to C, chromosome 2 at 76,898,128 bp
  • C to T, chromosome 2 at 104,992,088 bp
  • T to C, chromosome 2 at 132,078,436 bp
  • A to G, chromosome 3 at 24,171,642 bp
  • A to G, chromosome 3 at 58,691,553 bp
  • A to G, chromosome 3 at 114,112,467 bp
  • T to C, chromosome 4 at 58,123,180 bp
  • A to T, chromosome 4 at 63,149,474 bp
  • A to C, chromosome 4 at 132,204,961 bp
  • A to G, chromosome 5 at 129,541,441 bp
  • A to G, chromosome 6 at 83,155,127 bp
  • A to G, chromosome 6 at 124,517,759 bp
  • C to A, chromosome 7 at 16,865,905 bp
  • T to A, chromosome 7 at 45,694,356 bp
  • G to A, chromosome 7 at 109,048,062 bp
  • T to G, chromosome 8 at 22,675,036 bp
  • A to T, chromosome 8 at 122,891,921 bp
  • A to G, chromosome 9 at 39,646,661 bp
  • A to T, chromosome 9 at 67,386,664 bp
  • A to T, chromosome 9 at 99,320,293 bp
  • T to C, chromosome 9 at 110,636,905 bp
  • A to G, chromosome 9 at 122,862,058 bp
  • T to C, chromosome 10 at 20,323,769 bp
  • T to C, chromosome 10 at 40,585,302 bp
  • A to G, chromosome 10 at 43,582,676 bp
  • A to T, chromosome 10 at 80,027,597 bp
  • T to C, chromosome 10 at 128,240,635 bp
  • G to T, chromosome 11 at 42,593,931 bp
  • A to T, chromosome 11 at 100,093,709 bp
  • A to G, chromosome 11 at 115,329,492 bp
  • A to G, chromosome 12 at 55,762,727 bp
  • A to T, chromosome 12 at 57,688,640 bp
  • T to G, chromosome 12 at 73,272,472 bp
  • A to G, chromosome 12 at 76,239,509 bp
  • T to C, chromosome 13 at 38,192,210 bp
  • C to T, chromosome 13 at 55,550,361 bp
  • T to C, chromosome 13 at 96,904,127 bp
  • A to G, chromosome 14 at 7,904,536 bp
  • A to G, chromosome 14 at 32,170,793 bp
  • G to A, chromosome 15 at 74,853,514 bp
  • A to G, chromosome 15 at 97,245,464 bp
  • C to T, chromosome 15 at 101,887,478 bp
  • A to G, chromosome 16 at 4,549,447 bp
  • C to T, chromosome 16 at 8,602,436 bp
  • G to A, chromosome 17 at 20,554,523 bp
  • T to A, chromosome 17 at 20,954,717 bp
  • C to T, chromosome 17 at 57,256,899 bp
  • T to A, chromosome 17 at 71,100,398 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6738 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044856-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.