Strain Name:
C57BL/6J-MtgxR6746Btlr/Mmmh
Stock Number:
044863-MU
Citation ID:
RRID:MMRRC_044863-MU
Other Names:
R6746 (G1)
Major Collection:

Strain Information

Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Scd1
Name: stearoyl-Coenzyme A desaturase 1
Synonyms: stearoyl-CoA desaturase, Scd-1, SCD
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20249
VEGA: 19
Homologene: 74538
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Bltp3b
Name: bridge-like lipid transfer protein family member 3B
Synonyms: 4930506D01Rik, 2010319N22Rik, E030041M21Rik, Uhrf1bp1l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75089
VEGA: 10
Homologene: 12590
Chaf1a
Name: chromatin assembly factor 1, subunit A
Synonyms: CAF-1, p150
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27221
VEGA: 17
HGNC: HGNC:1910
Homologene: 4003
Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Synonyms: MAP1C, dynein heavy chain, retrograde transport, Dnec1, Loa, 9930018I23Rik, Dnchc1, Swl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13424
HGNC: HGNC:2961
Homologene: 1053
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Flrt3
Name: fibronectin leucine rich transmembrane protein 3
Synonyms: 5530600M07Rik, C430047I10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71436
HGNC: HGNC:3762
Homologene: 8322
Lypd5
Name: Ly6/Plaur domain containing 5
Synonyms: 2210003I03Rik, 2310011E23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76942
Homologene: 18797
Otor
Name: otoraplin
Synonyms: Fdp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57329
HGNC: HGNC:8517
Homologene: 10600
Hspa13
Name: heat shock protein 70 family, member 13
Synonyms: 60kDa, B230217N24Rik, 1600002I10Rik, Stch
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110920
Homologene: 5062
Spint2
Name: serine protease inhibitor, Kunitz type 2
Synonyms: HAI-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20733
Homologene: 7955
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: calcium release channel isoform 1, Ryr, skrr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20190
Homologene: 68069
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: mGluR6, nerg1, nob3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Ppm1m
Name: protein phosphatase 1M
Synonyms: 2810423O19Rik, PP2C eta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67905
Homologene: 44900
Rpl7l1
Name: ribosomal protein L7-like 1
Synonyms: 1500016H10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66229
VEGA: 17
Homologene: 41632
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, crash, Adgrc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Ppfia2
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms: E130120L08Rik, Liprin-alpha2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327814
VEGA: 10
HGNC: HGNC:9246
Homologene: 27953
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233231
Homologene: 24986
Arrb1
Name: arrestin, beta 1
Synonyms: 1200006I17Rik, beta-arrestin1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 109689
HGNC: HGNC:711
Homologene: 2981
Nsun7
Name: NOL1/NOP2/Sun domain family, member 7
Synonyms: 4921525L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70918
Homologene: 11653
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Erich6
Name: glutamate rich 6
Synonyms: 4932431H17Rik, Fam194a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545527
Homologene: 65043
Tarm1
Name: T cell-interacting, activating receptor on myeloid cells 1
Synonyms: 9930022N03Rik, Gm9904
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245126
Homologene: 120241
Semp2l1
Name: SUMO/sentrin specific peptidase 2-like 1
Synonyms: Gm5415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 408191
Homologene: 130042
Pik3cg
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Synonyms: PI3Kgamma, p110gamma, PI3Kgamma, PI(3)Kgamma, 5830428L06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30955
HGNC: HGNC:8978
Homologene: 68269
Pld2
Name: phospholipase D2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Hnf4g
Name: hepatocyte nuclear factor 4, gamma
Synonyms: NR2A2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 30942
HGNC: HGNC:5026
Homologene: 37886
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232367
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700111D19Rik, 4930445I03Rik, 1700001O02Rik, 1700041C02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73332
Homologene: 137391
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: Atp3a2, B230107D19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
Kash5
Name: KASH domain containing 5
Synonyms: LOC384619, Ccdc155
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384619
Homologene: 16973
Pon3
Name: paraoxonase 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269823
HGNC: HGNC:9206
Homologene: 37371
Plaat5
Name: phospholipase A and acyltransferase 5
Synonyms: 1700086E08Rik, 1700055A14Rik, 4921526K24Rik, iNAT, Hrasls5
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66727
Homologene: 12019
Brinp2
Name: bone morphogenic protein/retinoic acid inducible neural-specific 2
Synonyms: 6430517E21Rik, Fam5b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240843
Homologene: 10905
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245174
Homologene: 136215
Wdr35
Name: WD repeat domain 35
Synonyms: 4930459M12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74682
Homologene: 10814
Ilvbl
Name: ilvB (bacterial acetolactate synthase)-like
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216136
VEGA: 10
HGNC: HGNC:6041
Homologene: 68532
Or8k16
Name: olfactory receptor family 8 subfamily K member 16
Synonyms: GA_x6K02T2Q125-47170431-47171372, MOR187-3, Olfr1008
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258866
Or2ak6
Name: olfactory receptor family 2 subfamily AK member 6
Synonyms: GA_x6K02T2NKPP-708319-707399, MOR285-2, Olfr319
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258493
Fahd1
Name: fumarylacetoacetate hydrolase domain containing 1
Synonyms: 1110025H10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68636
VEGA: 17
Homologene: 6774
Acot3
Name: acyl-CoA thioesterase 3
Synonyms: PTE-Ia, Pte2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 171281
Homologene: 134585
Itga7
Name: integrin alpha 7
Synonyms: [a]7, alpha7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
Rbm4b
Name: RNA binding motif protein 4B
Synonyms: 4921506I22Rik, Lark2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66704
Homologene: 57033
Oasl1
Name: 2'-5' oligoadenylate synthetase-like 1
Synonyms: 7530414C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231655
HGNC: HGNC:8090
Homologene: 2769
Or7g22
Name: olfactory receptor family 7 subfamily G member 22
Synonyms: GA_x6K02T2PVTD-12873838-12874776, MOR152-2, Olfr837
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258558
HGNC: HGNC:8466
Homologene: 115507
Prss44
Name: serine protease 44
Synonyms: TESSP4, 1700036D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73336
Homologene: 135977
Rassf6
Name: Ras association (RalGDS/AF-6) domain family member 6
Synonyms: 1600016B17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73246
Homologene: 37125
Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Synonyms: B130032C06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208715
VEGA: 13
HGNC: HGNC:5007
Homologene: 1609
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 32,546,763 bp
  • G to T, chromosome 1 at 90,779,045 bp
  • C to T, chromosome 1 at 158,266,590 bp
  • T to C, chromosome 2 at 85,689,608 bp
  • C to T, chromosome 2 at 140,660,025 bp
  • T to A, chromosome 2 at 143,080,035 bp
  • A to T, chromosome 2 at 150,239,423 bp
  • T to G, chromosome 2 at 158,476,136 bp
  • C to A, chromosome 3 at 3,657,110 bp
  • T to C, chromosome 3 at 58,616,566 bp
  • T to C, chromosome 4 at 119,356,718 bp
  • T to C, chromosome 5 at 66,283,737 bp
  • A to T, chromosome 5 at 67,751,049 bp
  • C to A, chromosome 5 at 90,609,774 bp
  • T to A, chromosome 5 at 114,937,183 bp
  • A to T, chromosome 6 at 5,230,786 bp
  • T to G, chromosome 6 at 124,200,593 bp
  • T to A, chromosome 6 at 137,394,823 bp
  • T to A, chromosome 7 at 3,502,462 bp
  • G to T, chromosome 7 at 24,353,106 bp
  • A to T, chromosome 7 at 29,117,404 bp
  • A to T, chromosome 7 at 29,259,423 bp
  • C to T, chromosome 7 at 45,200,311 bp
  • A to C, chromosome 7 at 48,447,897 bp
  • A to C, chromosome 7 at 79,839,185 bp
  • T to C, chromosome 7 at 96,892,860 bp
  • A to G, chromosome 7 at 99,601,150 bp
  • A to G, chromosome 8 at 81,014,291 bp
  • A to G, chromosome 9 at 19,137,478 bp
  • A to T, chromosome 9 at 106,198,152 bp
  • A to T, chromosome 9 at 110,815,293 bp
  • T to C, chromosome 10 at 75,333,608 bp
  • T to C, chromosome 10 at 78,577,223 bp
  • T to A, chromosome 10 at 89,787,158 bp
  • C to A, chromosome 10 at 106,906,458 bp
  • A to T, chromosome 10 at 120,105,468 bp
  • T to C, chromosome 10 at 128,949,472 bp
  • A to T, chromosome 11 at 50,856,963 bp
  • G to A, chromosome 11 at 58,702,543 bp
  • C to A, chromosome 11 at 70,541,107 bp
  • A to T, chromosome 11 at 94,409,427 bp
  • T to A, chromosome 12 at 9,003,982 bp
  • A to G, chromosome 12 at 16,565,528 bp
  • G to A, chromosome 12 at 32,194,758 bp
  • A to G, chromosome 12 at 84,053,474 bp
  • A to T, chromosome 12 at 110,651,653 bp
  • T to C, chromosome 13 at 119,695,049 bp
  • A to G, chromosome 15 at 86,031,495 bp
  • A to T, chromosome 16 at 75,765,037 bp
  • A to T, chromosome 17 at 24,346,221 bp
  • G to T, chromosome 17 at 24,849,941 bp
  • C to T, chromosome 17 at 25,381,550 bp
  • A to G, chromosome 17 at 35,660,402 bp
  • T to C, chromosome 17 at 46,779,396 bp
  • A to G, chromosome 17 at 56,063,404 bp
  • A to C, chromosome 19 at 4,762,003 bp
  • A to G, chromosome 19 at 7,613,330 bp
  • G to T, chromosome 19 at 44,406,488 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6746 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044863-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.