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Strain Name:
C57BL/6J-MtgxR6746Btlr/Mmmh
Stock Number:
044863-MU
Citation ID:
RRID:MMRRC_044863-MU
Other Names:
R6746 (G1)
Major Collection:

Strain Information

Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Scd1
Name: stearoyl-Coenzyme A desaturase 1
Synonyms: stearoyl-CoA desaturase, Scd-1, SCD
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20249
VEGA: 19
Homologene: 74538
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Usp38
Name: ubiquitin specific peptidase 38
Synonyms: 4631402N15Rik, 4833420O05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74841
Homologene: 12367
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Ralgapb
Name: Ral GTPase activating protein, beta subunit (non-catalytic)
Synonyms: B230339M05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228850
Homologene: 10666
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 32,546,763 bp
  • G to T, chromosome 1 at 90,779,045 bp
  • C to T, chromosome 1 at 158,266,590 bp
  • T to C, chromosome 2 at 85,689,608 bp
  • C to T, chromosome 2 at 140,660,025 bp
  • T to A, chromosome 2 at 143,080,035 bp
  • A to T, chromosome 2 at 150,239,423 bp
  • T to G, chromosome 2 at 158,476,136 bp
  • C to A, chromosome 3 at 3,657,110 bp
  • T to C, chromosome 3 at 58,616,566 bp
  • T to C, chromosome 4 at 119,356,718 bp
  • T to C, chromosome 5 at 66,283,737 bp
  • A to T, chromosome 5 at 67,751,049 bp
  • C to A, chromosome 5 at 90,609,774 bp
  • T to A, chromosome 5 at 114,937,183 bp
  • A to T, chromosome 6 at 5,230,786 bp
  • T to G, chromosome 6 at 124,200,593 bp
  • T to A, chromosome 6 at 137,394,823 bp
  • T to A, chromosome 7 at 3,502,462 bp
  • G to T, chromosome 7 at 24,353,106 bp
  • A to T, chromosome 7 at 29,117,404 bp
  • A to T, chromosome 7 at 29,259,423 bp
  • C to T, chromosome 7 at 45,200,311 bp
  • A to C, chromosome 7 at 48,447,897 bp
  • A to C, chromosome 7 at 79,839,185 bp
  • T to C, chromosome 7 at 96,892,860 bp
  • A to G, chromosome 7 at 99,601,150 bp
  • A to G, chromosome 8 at 81,014,291 bp
  • A to G, chromosome 9 at 19,137,478 bp
  • A to T, chromosome 9 at 106,198,152 bp
  • A to T, chromosome 9 at 110,815,293 bp
  • T to C, chromosome 10 at 75,333,608 bp
  • T to C, chromosome 10 at 78,577,223 bp
  • T to A, chromosome 10 at 89,787,158 bp
  • C to A, chromosome 10 at 106,906,458 bp
  • A to T, chromosome 10 at 120,105,468 bp
  • T to C, chromosome 10 at 128,949,472 bp
  • A to T, chromosome 11 at 50,856,963 bp
  • G to A, chromosome 11 at 58,702,543 bp
  • C to A, chromosome 11 at 70,541,107 bp
  • A to T, chromosome 11 at 94,409,427 bp
  • T to A, chromosome 12 at 9,003,982 bp
  • A to G, chromosome 12 at 16,565,528 bp
  • G to A, chromosome 12 at 32,194,758 bp
  • A to G, chromosome 12 at 84,053,474 bp
  • A to T, chromosome 12 at 110,651,653 bp
  • T to C, chromosome 13 at 119,695,049 bp
  • A to G, chromosome 15 at 86,031,495 bp
  • A to T, chromosome 16 at 75,765,037 bp
  • A to T, chromosome 17 at 24,346,221 bp
  • G to T, chromosome 17 at 24,849,941 bp
  • C to T, chromosome 17 at 25,381,550 bp
  • A to G, chromosome 17 at 35,660,402 bp
  • T to C, chromosome 17 at 46,779,396 bp
  • A to G, chromosome 17 at 56,063,404 bp
  • A to C, chromosome 19 at 4,762,003 bp
  • A to G, chromosome 19 at 7,613,330 bp
  • G to T, chromosome 19 at 44,406,488 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6746 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044863-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.