Strain Name:
C57BL/6J-MtgxR6755Btlr/Mmmh
Stock Number:
044871-MU
Citation ID:
RRID:MMRRC_044871-MU
Other Names:
R6755 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
B4galt6
Name: UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 56386
VEGA: 18
HGNC: HGNC:929
Homologene: 3506
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: MYH-beta/slow, Myhc-b, B-MHC, beta-MHC, betaMHC, MyHC-I, Myhcb
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Magi1
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1
Synonyms: Gukmi1, Baiap1, BAP1, WWP3, AIP3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14924
HGNC: HGNC:946
Homologene: 31257
Med26
Name: mediator complex subunit 26
Synonyms: Crsp7, 5730493L18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70625
HGNC: HGNC:2376
Homologene: 68417
Cdk8
Name: cyclin dependent kinase 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: AP162, B2, D330036J23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Taok3
Name: TAO kinase 3
Synonyms: 2900006A08Rik, A430105I05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330177
Homologene: 83279
Kif11
Name: kinesin family member 11
Synonyms: Kifl1, Eg5, Knsl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16551
VEGA: 19
HGNC: HGNC:6388
Homologene: 3322
Ptpn23
Name: protein tyrosine phosphatase, non-receptor type 23
Synonyms: PTP-TD14
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104831
Homologene: 135706
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Ars2, Asr2, 2810019G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Cbl
Name: Casitas B-lineage lymphoma
Synonyms: c-Cbl, 4732447J05Rik, Cbl-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12402
HGNC: HGNC:1541
Homologene: 3802
Ufl1
Name: UFM1 specific ligase 1
Synonyms: 1810074P20Rik, Maxer, Rcad
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67490
Homologene: 9093
Snx32
Name: sorting nexin 32
Synonyms: B930037P14Rik, Snx6b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225861
VEGA: 19
Homologene: 62637
Ahi1
Name: Abelson helper integration site 1
Synonyms: D10Bwg0629e, Jouberin, 1700015F03Rik, Ahi-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Cables1
Name: CDK5 and Abl enzyme substrate 1
Synonyms: interactor-1 with cdk3, ik3-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 63955
VEGA: 18
Homologene: 11097
Adam33
Name: a disintegrin and metallopeptidase domain 33
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110751
Homologene: 11881
Pianp
Name: PILR alpha associated neural protein
Synonyms: C530028O21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319352
Homologene: 17799
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: NGL-2, Nag14, NGL2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192198
Homologene: 36403
Rasa1
Name: RAS p21 protein activator 1
Synonyms: Gap, p120-rasGAP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Tmbim6
Name: transmembrane BAX inhibitor motif containing 6
Synonyms: Tegt, Bax inhibitor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110213
Homologene: 2419
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Nhlrc2
Name: NHL repeat containing 2
Synonyms: 1200003G01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66866
VEGA: 19
Homologene: 12048
Tm7sf3
Name: transmembrane 7 superfamily member 3
Synonyms: 2010003B14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67623
Homologene: 9560
Elp6
Name: elongator acetyltransferase complex subunit 6
Synonyms: 2610001P13Rik, Tmem103, 2610002I17Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72341
Homologene: 9794
Nup160
Name: nucleoporin 160
Synonyms: 2810011M03Rik, Gtl1-13
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59015
Homologene: 32509
Tmem107
Name: transmembrane protein 107
Synonyms: 1110004B13Rik, 2810049P21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66910
Homologene: 12052
Ift172
Name: intraflagellar transport 172
Synonyms: 4930553F24Rik, wim, avc1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67661
Homologene: 15202
Fgf10
Name: fibroblast growth factor 10
Synonyms: Gsfaey17, AEY17, FGF-10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14165
HGNC: HGNC:3666
Homologene: 3284
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Il20ra
Name: interleukin 20 receptor, alpha
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237313
VEGA: 10
HGNC: HGNC:6003
Homologene: 8685
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC234973, LOC382129, 9430076A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Plekhh2
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213556
VEGA: 17
Homologene: 35317
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21754
Homologene: 4577
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
C3ar1
Name: complement component 3a receptor 1
Synonyms: C3aR, anaphylatoxin C3a receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12267
HGNC: HGNC:1319
Homologene: 2992
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Ptafr
Name: platelet-activating factor receptor
Synonyms: PAFR, PAF receptor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19204
HGNC: HGNC:9582
Homologene: 20260
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Bpifb4
Name: BPI fold containing family B, member 4
Synonyms: Gm1006, LOC381399
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381399
Homologene: 66971
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: Nmf350, D930002M15Rik, PKB gamma
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Ppp4r4
Name: protein phosphatase 4, regulatory subunit 4
Synonyms: 8430415E04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74521
Homologene: 12571
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: b2b1654Clo, Ccdc164, Gm1060, LOC381738
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
2210408I21Rik
Name: RIKEN cDNA 2210408I21 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72371
Homologene: 89234
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Ctso
Name: cathepsin O
Synonyms: A330105D01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229445
HGNC: HGNC:2542
Homologene: 1020
Mgst1
Name: microsomal glutathione S-transferase 1
Synonyms: 1500002K10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56615
HGNC: HGNC:7061
Homologene: 10544
Isg20l2
Name: interferon stimulated exonuclease gene 20-like 2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229504
Homologene: 12814
Hif1an
Name: hypoxia-inducible factor 1, alpha subunit inhibitor
Synonyms: 2310046M24Rik, FIH, A830014H24Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319594
Homologene: 9906
Slc38a11
Name: solute carrier family 38, member 11
Synonyms: 9330158F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320106
Homologene: 5775
Poglut2
Name: protein O-glucosyltransferase 2
Synonyms: 5730416C13Rik, EP58, Kdelc1, Kdel1, 1810049A15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72050
Homologene: 11367
4930433I11Rik
Name: RIKEN cDNA 4930433I11 gene
Synonyms: LOC243944
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243944
Homologene: 77912
Syce3
Name: synaptonemal complex central element protein 3
Synonyms: 1700007E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75459
Homologene: 85810
Or52ae9
Name: olfactory receptor family 52 subfamily AE member 9
Synonyms: Olfr629, GA_x6K02T2PBJ9-6466772-6465828, MOR26-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258818
Homologene: 105159
Or5ak4
Name: olfactory receptor family 5 subfamily AK member 4
Synonyms: GA_x6K02T2Q125-46808500-46807571, MOR203-7P, Olfr987
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257951
Homologene: 103791
Ttc12
Name: tetratricopeptide repeat domain 12
Synonyms: E330017O07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235330
Homologene: 32375
Sap18
Name: Sin3-associated polypeptide 18
Synonyms: D11Ertd539e, Sinbp1, C530046K05Rik, Sap18a, EMegR4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20220
Homologene: 4289
Pramel52-ps
Name: PRAME like 52, pseudogene
Synonyms: AA792892
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100554
Homologene: 133359
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 44,110,734 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • C to A, chromosome 1 at 188,443,219 bp
  • C to T, chromosome 2 at 65,363,891 bp
  • C to A, chromosome 2 at 85,331,798 bp
  • T to G, chromosome 2 at 90,700,456 bp
  • A to G, chromosome 2 at 131,053,149 bp
  • A to G, chromosome 2 at 153,957,738 bp
  • T to A, chromosome 3 at 81,942,302 bp
  • T to A, chromosome 3 at 87,931,689 bp
  • T to A, chromosome 4 at 25,262,316 bp
  • A to G, chromosome 4 at 43,445,991 bp
  • A to G, chromosome 4 at 132,579,346 bp
  • T to A, chromosome 4 at 139,966,475 bp
  • T to C, chromosome 4 at 141,964,604 bp
  • A to G, chromosome 5 at 30,355,146 bp
  • T to A, chromosome 5 at 31,260,998 bp
  • A to G, chromosome 5 at 94,381,409 bp
  • T to A, chromosome 5 at 117,206,667 bp
  • T to C, chromosome 5 at 137,302,930 bp
  • T to A, chromosome 5 at 146,268,316 bp
  • T to C, chromosome 6 at 28,831,293 bp
  • C to T, chromosome 6 at 93,708,177 bp
  • T to C, chromosome 6 at 96,164,972 bp
  • A to G, chromosome 6 at 122,849,858 bp
  • T to C, chromosome 6 at 124,999,384 bp
  • T to A, chromosome 6 at 138,147,772 bp
  • A to T, chromosome 6 at 146,609,973 bp
  • T to C, chromosome 7 at 40,994,310 bp
  • T to A, chromosome 7 at 103,740,500 bp
  • T to C, chromosome 7 at 115,662,442 bp
  • A to G, chromosome 8 at 72,495,833 bp
  • T to C, chromosome 8 at 104,619,248 bp
  • C to T, chromosome 9 at 15,915,061 bp
  • T to C, chromosome 9 at 44,173,374 bp
  • T to C, chromosome 9 at 49,453,346 bp
  • A to G, chromosome 9 at 110,315,825 bp
  • A to T, chromosome 9 at 110,389,787 bp
  • A to T, chromosome 10 at 12,699,087 bp
  • T to C, chromosome 10 at 19,750,794 bp
  • G to T, chromosome 10 at 21,017,913 bp
  • A to T, chromosome 10 at 107,853,303 bp
  • A to T, chromosome 11 at 59,103,326 bp
  • T to C, chromosome 11 at 69,071,011 bp
  • G to T, chromosome 11 at 103,387,243 bp
  • A to T, chromosome 11 at 107,047,256 bp
  • T to A, chromosome 12 at 84,795,073 bp
  • T to A, chromosome 12 at 103,585,737 bp
  • C to T, chromosome 13 at 77,327,875 bp
  • A to T, chromosome 13 at 85,226,598 bp
  • C to A, chromosome 13 at 118,789,285 bp
  • G to A, chromosome 14 at 54,992,313 bp
  • A to C, chromosome 14 at 57,802,017 bp
  • T to C, chromosome 15 at 89,397,364 bp
  • T to C, chromosome 15 at 99,402,153 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • A to T, chromosome 16 at 30,260,331 bp
  • G to A, chromosome 16 at 35,303,634 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • T to C, chromosome 17 at 84,591,585 bp
  • G to T, chromosome 18 at 11,939,825 bp
  • T to C, chromosome 18 at 20,689,329 bp
  • A to G, chromosome 18 at 58,113,333 bp
  • T to C, chromosome 19 at 5,510,344 bp
  • A to G, chromosome 19 at 37,409,751 bp
  • T to C, chromosome 19 at 44,568,452 bp
  • G to A, chromosome 19 at 56,591,784 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6755 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044871-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.