Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6768Btlr/Mmmh
Stock Number:
044884-MU
Citation ID:
RRID:MMRRC_044884-MU
Other Names:
R6768 (G1)
Major Collection:

Strain Information

Eno2
Name: enolase 2, gamma neuronal
Synonyms: Eno-2, D6Ertd375e, NSE
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Agtrap
Name: angiotensin II, type I receptor-associated protein
Synonyms: Atrap, D4Wsu124e, 3300002E14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11610
Homologene: 7621
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: 0610010J20Rik, 2610524G04Rik, D15Ertd785e, Kleisin beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52683
Homologene: 12045
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: c-Cbl-associated protein, CAP, Sh3d5, 2310065E01Rik, 9530001P15Rik, Ponsin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Mtf1
Name: metal response element binding transcription factor 1
Synonyms: MTF-1, metal response element-binding transcription factor 1, metalloregulatory transcription factor, Thyls
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17764
HGNC: HGNC:7428
Homologene: 4347
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Sdhb
Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Synonyms: 0710008N11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67680
Homologene: 2255
Colec11
Name: collectin sub-family member 11
Synonyms: 1010001H16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71693
VEGA: 12
Homologene: 11423
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: PAF65A, C530024J06Rik, 2810417N14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225895
Homologene: 4728
Bmper
Name: BMP-binding endothelial regulator
Synonyms: Cv2, 3110056H04Rik, CV-2, Crim3, crossveinless-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73230
VEGA: 9
Homologene: 12494
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Scgb2b26
Name: secretoglobin, family 2B, member 26
Synonyms: C2d, Scgb2b4, Abpg, Abpbg4, Abpbg26
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110187
Homologene: 83171
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320683
Homologene: 65318
Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Synonyms: CAR1, MB67, Care2, ESTM32, mCAR, CAR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12355
HGNC: HGNC:7969
Homologene: 3759
Casq1
Name: calsequestrin 1
Synonyms: CSQ-1, CSQ1, CSQ, sCSQ
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12372
HGNC: HGNC:1512
Homologene: 20329
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628444
Homologene: 129683
Tuba3b
Name: tubulin, alpha 3B
Synonyms: M[a]7, Tuba7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22147
Homologene: 128229
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330485
Homologene: 18333
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: Ahd-3r, Ahd-3, Ahd3-r, Ahd3, Aldh4, Aldh4-r, FALDH
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
Foxa2
Name: forkhead box A2
Synonyms: Tcf-3b, Hnf-3b, Tcf3b, Hnf3b, HNF3beta, HNF3-beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15376
HGNC: HGNC:5022
Homologene: 7762
Ctcfl
Name: CCCTC-binding factor like
Synonyms: Boris, OTTMUSG00000016680
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 664799
Homologene: 46476
Zfp11
Name: zinc finger protein 11
Synonyms: Krox-6, Zfp-11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22648
Homologene: 87241
Adam6b
Name: a disintegrin and metallopeptidase domain 6B
Synonyms: 4930523C11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238405
Homologene: 128362
Or13c7
Name: olfactory receptor family 13 subfamily C member 7
Synonyms: OR37A, mOR37a, Olfr37a, GA_x6K02T2N78B-16092200-16091241, MOR262-14, Olfr155
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 29845
Homologene: 84331
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Cstpp1
Name: centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Synonyms: 1110051M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228356
Homologene: 11471
Vmn1r168
Name: vomeronasal 1 receptor 168
Synonyms: Gm10659
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043101
Homologene: 122945
Meox1
Name: mesenchyme homeobox 1
Synonyms: Mox-1, Mox1, D330041M02Rik, squig
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17285
HGNC: HGNC:7013
Homologene: 3326
Or11h4b
Name: olfactory receptor family 11 subfamily H member 4B
Synonyms: GA_x6K02T2PMLR-6420220-6419279, MOR106-7, MOR106-16, Olfr747
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258264
Homologene: 10652
Igsf8
Name: immunoglobulin superfamily, member 8
Synonyms: ESTM34, EWI-2, PG regulatory-like protein, PGRL, KCT-4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 140559
Homologene: 14163
Zfpm1
Name: zinc finger protein, multitype 1
Synonyms: Friend of GATA-1, Fog1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22761
Homologene: 7606
Cpeb3
Name: cytoplasmic polyadenylation element binding protein 3
Synonyms: 4831444O18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 208922
Homologene: 40992
Zfp428
Name: zinc finger protein 428
Synonyms: 2410005H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232969
Homologene: 18789
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Ccin
Name: calicin
Synonyms: 4933417A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 442829
HGNC: HGNC:1568
Homologene: 4306
Islr
Name: immunoglobulin superfamily containing leucine-rich repeat
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26968
VEGA: 9
HGNC: HGNC:6133
Homologene: 4050
Ubl7
Name: ubiquitin-like 7 (bone marrow stromal cell-derived)
Synonyms: 2300004C15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69459
VEGA: 9
Homologene: 12312
Panx3
Name: pannexin 3
Synonyms: 4833413G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208098
Homologene: 82335
Josd1
Name: Josephin domain containing 1
Synonyms: 1300006C06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74158
VEGA: 15
Homologene: 122222
Gm47189
Name: predicted gene, 47189
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,181,712 bp
  • T to A, chromosome 1 at 75,532,635 bp
  • G to A, chromosome 1 at 171,217,397 bp
  • C to T, chromosome 1 at 172,219,678 bp
  • C to A, chromosome 1 at 172,317,532 bp
  • A to G, chromosome 2 at 32,686,623 bp
  • A to T, chromosome 2 at 91,421,958 bp
  • T to C, chromosome 2 at 148,043,827 bp
  • A to G, chromosome 2 at 173,117,291 bp
  • T to C, chromosome 4 at 43,854,351 bp
  • G to A, chromosome 4 at 43,984,574 bp
  • G to A, chromosome 4 at 124,837,785 bp
  • A to G, chromosome 4 at 140,979,053 bp
  • A to G, chromosome 4 at 148,081,610 bp
  • A to C, chromosome 5 at 21,978,907 bp
  • G to T, chromosome 5 at 129,658,351 bp
  • T to C, chromosome 6 at 124,767,748 bp
  • T to A, chromosome 6 at 145,618,729 bp
  • A to T, chromosome 7 at 23,541,035 bp
  • G to A, chromosome 7 at 24,515,483 bp
  • G to A, chromosome 7 at 25,308,636 bp
  • G to T, chromosome 7 at 33,944,954 bp
  • C to A, chromosome 7 at 42,011,968 bp
  • C to T, chromosome 7 at 42,300,324 bp
  • G to A, chromosome 7 at 127,610,825 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • C to A, chromosome 8 at 122,334,456 bp
  • T to A, chromosome 9 at 23,381,453 bp
  • T to C, chromosome 9 at 37,664,026 bp
  • A to T, chromosome 9 at 57,912,762 bp
  • G to T, chromosome 9 at 58,157,610 bp
  • A to C, chromosome 11 at 61,253,710 bp
  • A to G, chromosome 11 at 101,879,335 bp
  • G to A, chromosome 11 at 103,500,123 bp
  • G to T, chromosome 11 at 119,442,236 bp
  • T to C, chromosome 12 at 28,595,101 bp
  • G to A, chromosome 12 at 113,490,243 bp
  • A to T, chromosome 13 at 100,178,324 bp
  • A to G, chromosome 14 at 41,770,078 bp
  • A to G, chromosome 14 at 50,681,592 bp
  • G to T, chromosome 15 at 58,054,103 bp
  • A to G, chromosome 15 at 79,677,122 bp
  • T to A, chromosome 15 at 89,363,999 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • A to C, chromosome 19 at 8,774,549 bp
  • G to A, chromosome 19 at 37,025,032 bp
  • A to T, chromosome 19 at 40,327,547 bp
  • A to G, chromosome 19 at 44,096,951 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.