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Strain Name:
C57BL/6J-MtgxR6768Btlr/Mmmh
Stock Number:
044884-MU
Citation ID:
RRID:MMRRC_044884-MU
Other Names:
R6768 (G1)
Major Collection:

Strain Information

Eno2
Name: enolase 2, gamma neuronal
Synonyms: Eno-2, D6Ertd375e, NSE
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13807
HGNC: HGNC:3353
Homologene: 74414
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Agtrap
Name: angiotensin II, type I receptor-associated protein
Synonyms: Atrap, D4Wsu124e, 3300002E14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11610
Homologene: 7621
Chuk
Name: conserved helix-loop-helix ubiquitous kinase
Synonyms: Chuk1, IKK1, IKK[a], IKK-alpha, IkappaB kinase alpha, IKK 1, IKK alpha, IKKalpha, IKK-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12675
HGNC: HGNC:1974
Homologene: 979
Stk11ip
Name: serine/threonine kinase 11 interacting protein
Synonyms: LKB1IP, LIP1, 1200014D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71728
Homologene: 12406
Ncaph2
Name: non-SMC condensin II complex, subunit H2
Synonyms: 0610010J20Rik, 2610524G04Rik, D15Ertd785e, Kleisin beta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52683
Homologene: 12045
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,181,712 bp
  • T to A, chromosome 1 at 75,532,635 bp
  • G to A, chromosome 1 at 171,217,397 bp
  • C to T, chromosome 1 at 172,219,678 bp
  • C to A, chromosome 1 at 172,317,532 bp
  • A to G, chromosome 2 at 32,686,623 bp
  • A to T, chromosome 2 at 91,421,958 bp
  • T to C, chromosome 2 at 148,043,827 bp
  • A to G, chromosome 2 at 173,117,291 bp
  • T to C, chromosome 4 at 43,854,351 bp
  • G to A, chromosome 4 at 43,984,574 bp
  • G to A, chromosome 4 at 124,837,785 bp
  • A to G, chromosome 4 at 140,979,053 bp
  • A to G, chromosome 4 at 148,081,610 bp
  • A to C, chromosome 5 at 21,978,907 bp
  • G to T, chromosome 5 at 129,658,351 bp
  • T to C, chromosome 6 at 124,767,748 bp
  • T to A, chromosome 6 at 145,618,729 bp
  • A to T, chromosome 7 at 23,541,035 bp
  • G to A, chromosome 7 at 24,515,483 bp
  • G to A, chromosome 7 at 25,308,636 bp
  • G to T, chromosome 7 at 33,944,954 bp
  • C to A, chromosome 7 at 42,011,968 bp
  • C to T, chromosome 7 at 42,300,324 bp
  • G to A, chromosome 7 at 127,610,825 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • C to A, chromosome 8 at 122,334,456 bp
  • T to A, chromosome 9 at 23,381,453 bp
  • T to C, chromosome 9 at 37,664,026 bp
  • A to T, chromosome 9 at 57,912,762 bp
  • G to T, chromosome 9 at 58,157,610 bp
  • A to C, chromosome 11 at 61,253,710 bp
  • A to G, chromosome 11 at 101,879,335 bp
  • G to A, chromosome 11 at 103,500,123 bp
  • G to T, chromosome 11 at 119,442,236 bp
  • T to C, chromosome 12 at 28,595,101 bp
  • G to A, chromosome 12 at 113,490,243 bp
  • A to T, chromosome 13 at 100,178,324 bp
  • A to G, chromosome 14 at 41,770,078 bp
  • A to G, chromosome 14 at 50,681,592 bp
  • G to T, chromosome 15 at 58,054,103 bp
  • A to G, chromosome 15 at 79,677,122 bp
  • T to A, chromosome 15 at 89,363,999 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • A to C, chromosome 19 at 8,774,549 bp
  • G to A, chromosome 19 at 37,025,032 bp
  • A to T, chromosome 19 at 40,327,547 bp
  • A to G, chromosome 19 at 44,096,951 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6768 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.