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Strain Name:
C57BL/6J-MtgxR6773Btlr/Mmmh
Stock Number:
044889-MU
Citation ID:
RRID:MMRRC_044889-MU
Other Names:
R6773 (G1)
Major Collection:

Strain Information

Prune1
Name: prune exopolyphosphatase
Synonyms: 9230112O05Rik, Prune-M1, Prune
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229589
Homologene: 41429
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Nedd4l
Name: neural precursor cell expressed, developmentally down-regulated gene 4-like
Synonyms: 1300012C07Rik, Nedd4-2, Nedd4b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 83814
VEGA: 18
HGNC: HGNC:7728
Homologene: 86986
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Rbbp6
Name: retinoblastoma binding protein 6, ubiquitin ligase
Synonyms: 4933422O15Rik, C030034J04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19647
HGNC: HGNC:9889
Homologene: 136812
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 2810429C13Rik, 1110031N14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 6030402H20Rik, 2610019A05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72149
Homologene: 12448
Tmem259
Name: transmembrane protein 259
Synonyms: membralin, ORF61
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216157
Homologene: 14122
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 8430415E05Rik, 1700034M03Rik, Ccdc132
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: Ap-2 (a), AP-2 alpha, Ap2tf, Ap2, Tcfap2a, AP2alpha
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
M1ap
Name: meiosis 1 associated protein
Synonyms: D6Mm5e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110958
Homologene: 13210
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+K+-transporting alpha 1, H+/K+-ATPase alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Cd82
Name: CD82 antigen
Synonyms: C33, Tspan27, Kai1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12521
HGNC: HGNC:6210
Homologene: 20512
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Dok7
Name: docking protein 7
Synonyms: EF-12, A930013K19Rik, Dok-7, Oit5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231134
Homologene: 18210
Svep1
Name: sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
Synonyms: 4833413O10Rik, D430029O09Rik, 1110021D17Rik, Polydom
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64817
Homologene: 23386
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78317
VEGA: 19
Homologene: 49992
Asns
Name: asparagine synthetase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27053
HGNC: HGNC:753
Homologene: 69113
Plcl1
Name: phospholipase C-like 1
Synonyms: PLC-L, C230017K02Rik, PRIP-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227120
HGNC: HGNC:9063
Homologene: 38155
Dpy19l1
Name: dpy-19 like C-mannosyltransferase 1
Synonyms: 1100001I19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244745
Homologene: 14762
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030018G17Rik, 1110018I21Rik, Tns, E030037J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Shisa9
Name: shisa family member 9
Synonyms: 2700045P11Rik, CKAMP44
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72555
Homologene: 109462
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Cnot6l
Name: CCR4-NOT transcription complex, subunit 6-like
Synonyms: 4932442K20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231464
Homologene: 100830
Cxcr6
Name: C-X-C motif chemokine receptor 6
Synonyms: STRL33, BONZO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80901
VEGA: 9
Homologene: 38197
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: 0610010C24Rik, ASM3A, ASML3A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57319
Homologene: 4886
Kcnj13
Name: potassium inwardly-rectifying channel, subfamily J, member 13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100040591
HGNC: HGNC:6259
Homologene: 55638
Adrm1b
Name: adhesion regulating molecule 1B
Synonyms: Gm9774
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043022
Ccdc70
Name: coiled-coil domain containing 70
Synonyms: 1700112P19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67929
Homologene: 12214
Gpr153
Name: G protein-coupled receptor 153
Synonyms: 1110065N12Rik, PGR1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100129
Homologene: 18662
Klri1
Name: killer cell lectin-like receptor family I member 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 503550
Homologene: 86735
Tulp1
Name: TUB like protein 1
Synonyms: Tulp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22157
Homologene: 2491
Or5ac24
Name: olfactory receptor family 5 subfamily AC member 24
Synonyms: GA_x54KRFPKG5P-55560552-55559632, MOR182-4, Olfr206
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258993
Homologene: 74262
Aqp6
Name: aquaporin 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11831
VEGA: 15
HGNC: HGNC:639
Homologene: 20399
Rit1
Name: Ras-like without CAAX 1
Synonyms: Rit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19769
Homologene: 56003
Trbv5
Name: T cell receptor beta, variable 5
Synonyms: Tcrb-V1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124661
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 55,751,302 bp
  • T to C, chromosome 1 at 66,651,543 bp
  • T to C, chromosome 1 at 73,919,707 bp
  • T to C, chromosome 1 at 87,386,760 bp
  • G to A, chromosome 2 at 93,421,876 bp
  • A to T, chromosome 2 at 114,148,996 bp
  • C to T, chromosome 3 at 88,726,369 bp
  • T to A, chromosome 3 at 92,429,249 bp
  • T to C, chromosome 3 at 95,263,771 bp
  • C to T, chromosome 4 at 58,049,146 bp
  • T to A, chromosome 4 at 152,279,300 bp
  • G to A, chromosome 5 at 35,077,184 bp
  • A to C, chromosome 5 at 96,094,299 bp
  • T to C, chromosome 6 at 3,592,560 bp
  • C to A, chromosome 6 at 7,676,284 bp
  • G to T, chromosome 6 at 41,062,617 bp
  • T to A, chromosome 6 at 82,968,080 bp
  • C to T, chromosome 6 at 129,703,547 bp
  • T to C, chromosome 7 at 30,715,377 bp
  • GCG to GCGACGGCGACG, chromosome 7 at 97,579,907 bp
  • A to G, chromosome 7 at 122,999,355 bp
  • T to C, chromosome 7 at 139,642,561 bp
  • A to G, chromosome 8 at 21,973,305 bp
  • A to G, chromosome 8 at 79,643,806 bp
  • A to C, chromosome 8 at 80,611,815 bp
  • G to A, chromosome 8 at 81,856,620 bp
  • A to T, chromosome 9 at 8,634,057 bp
  • A to T, chromosome 9 at 24,440,772 bp
  • A to G, chromosome 9 at 103,343,692 bp
  • A to T, chromosome 9 at 106,693,317 bp
  • T to C, chromosome 9 at 110,034,925 bp
  • A to T, chromosome 9 at 123,810,290 bp
  • T to C, chromosome 10 at 57,802,437 bp
  • T to C, chromosome 10 at 79,977,588 bp
  • T to A, chromosome 11 at 29,205,639 bp
  • T to A, chromosome 11 at 106,164,907 bp
  • T to A, chromosome 13 at 40,728,754 bp
  • A to T, chromosome 15 at 84,914,159 bp
  • A to G, chromosome 15 at 99,602,677 bp
  • A to G, chromosome 16 at 11,985,028 bp
  • A to T, chromosome 16 at 17,209,015 bp
  • A to T, chromosome 16 at 59,345,216 bp
  • T to C, chromosome 17 at 28,362,902 bp
  • T to C, chromosome 18 at 65,167,551 bp
  • A to T, chromosome 19 at 6,849,041 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6773 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044889-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.