Strain Name:
C57BL/6J-MtgxR6778Btlr/Mmmh
Stock Number:
044894-MU
Citation ID:
RRID:MMRRC_044894-MU
Other Names:
R6778 (G1)
Major Collection:

Strain Information

Casq2
Name: calsequestrin 2
Synonyms: cardiac calsequestrin, ESTM52, Csq2, cCSQ
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12373
HGNC: HGNC:1513
Homologene: 20330
Pitx2
Name: paired-like homeodomain transcription factor 2
Synonyms: Brx1b, Brx1a, Brx1, solurshin, Pitx2a, Pitx2b, Pitx2c, Rieg, Otlx2, Ptx2, Munc30
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18741
HGNC: HGNC:9005
Homologene: 55454
Fubp3
Name: far upstream element (FUSE) binding protein 3
Synonyms: FBP3, Marta2, A330051M14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320267
HGNC: HGNC:4005
Homologene: 45954
Wdr47
Name: WD repeat domain 47
Synonyms: nemitin, 1810073M12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99512
Homologene: 8984
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Tbl1xr1
Name: transducin (beta)-like 1X-linked receptor 1
Synonyms: TBLR1, DC42, C230089I12Rik, Ira1, A630076E03Rik, 8030499H02Rik, C21
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 81004
Homologene: 69382
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Dzip3
Name: DAZ interacting protein 3, zinc finger
Synonyms: 2A-HUB, 6430549P11Rik, 2310047C04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224170
Homologene: 8771
Mvk
Name: mevalonate kinase
Synonyms: 2310010A05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17855
HGNC: HGNC:7530
Homologene: 372
Tnc
Name: tenascin C
Synonyms: hexabrachion, C130033P17Rik, cytotactin, TN-C, tenascin-C, Hxb, TN
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Sgk3
Name: serum/glucocorticoid regulated kinase 3
Synonyms: cytokine-independent survival kinase, Cisk, 2510015P22Rik, A330005P07Rik, fy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170755
Homologene: 56582
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Tars1
Name: threonyl-tRNA synthetase 1
Synonyms: Tars, ThrRS, D15Wsu59e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110960
VEGA: 15
Homologene: 11852
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83704
Homologene: 5429
Dlat
Name: dihydrolipoamide S-acetyltransferase
Synonyms: PDC-E2, 6332404G05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235339
HGNC: HGNC:2896
Homologene: 6814
Olfml2b
Name: olfactomedin-like 2B
Synonyms: photomedin-2, 1110018N05Rik, 4832415H08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320078
Homologene: 18546
Trpc7
Name: transient receptor potential cation channel, subfamily C, member 7
Synonyms: TRP7, Trrp8
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26946
Homologene: 22689
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Rdh10
Name: retinol dehydrogenase 10 (all-trans)
Synonyms: m366Asp, D1Ertd762e, 4921506A21Rik, 3110069K09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98711
Homologene: 14061
Npsr1
Name: neuropeptide S receptor 1
Synonyms: Gpr154, PGR14, VRR1, 9330128H10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319239
Homologene: 45515
Aoc2
Name: amine oxidase copper containing 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237940
HGNC: HGNC:549
Homologene: 56457
Ifitm6
Name: interferon induced transmembrane protein 6
Synonyms: fragilis5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 213002
Homologene: 72556
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330485
Homologene: 18333
Rin1
Name: Ras and Rab interactor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225870
VEGA: 19
Homologene: 3170
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: D330013L20Rik, Wdr67, LOC210544
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
Or10d4c
Name: olfactory receptor family 10 subfamily D member 4C
Synonyms: GA_x6K02T2PVTD-33343617-33344561, Olfr961, MOR224-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258497
VEGA: 9
Homologene: 74020
Vmn1r71
Name: vomeronasal 1 receptor 71
Synonyms: V1re13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252910
Homologene: 74352
Spata31f3
Name: spermatogenesis associated 31 subfamily F member 3
Synonyms: Fam205c, BC049635
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277773
Homologene: 77625
Tmprss11d
Name: transmembrane protease, serine 11d
Synonyms: AsP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231382
Homologene: 74519
Ccdc7a
Name: coiled-coil domain containing 7A
Synonyms: 4930540C21Rik, 4930517G15Rik, Ccdc7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74703
Homologene: 134760
Ffar4
Name: free fatty acid receptor 4
Synonyms: Gpr120, O3far1, Gpr129, Pgr4, Ffa4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107221
VEGA: 19
Homologene: 18769
Apol9a
Name: apolipoprotein L 9a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223672
VEGA: 15
Homologene: 77567
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230868
Homologene: 13153
Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif 14
Synonyms: TS14, Adamts-14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237360
Homologene: 16383
Sgpp1
Name: sphingosine-1-phosphate phosphatase 1
Synonyms: SPP1, mSPP1, SPP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 81535
VEGA: 12
Homologene: 101696
Npas2
Name: neuronal PAS domain protein 2
Synonyms: MOP4, bHLHe9
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18143
HGNC: HGNC:7895
Homologene: 1887
Igkv4-80
Name: immunoglobulin kappa variable 4-80
Synonyms: Gm16729
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545848
Gm7489
Name: predicted gene 7489
Type: Gene
Species: Mouse
Chromosome: 15
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 9,886,144 bp
  • T to C, chromosome 1 at 16,106,184 bp
  • T to A, chromosome 1 at 39,325,300 bp
  • A to G, chromosome 1 at 170,645,070 bp
  • A to T, chromosome 2 at 31,598,673 bp
  • T to A, chromosome 3 at 22,189,782 bp
  • T to A, chromosome 3 at 102,127,931 bp
  • T to A, chromosome 3 at 108,633,096 bp
  • C to T, chromosome 3 at 129,218,743 bp
  • T to C, chromosome 4 at 42,868,522 bp
  • T to G, chromosome 4 at 63,995,598 bp
  • A to T, chromosome 4 at 98,761,505 bp
  • G to T, chromosome 4 at 140,034,648 bp
  • T to C, chromosome 5 at 86,309,350 bp
  • T to A, chromosome 5 at 114,452,380 bp
  • T to C, chromosome 5 at 137,315,081 bp
  • A to T, chromosome 6 at 69,016,561 bp
  • C to T, chromosome 7 at 10,748,216 bp
  • G to A, chromosome 7 at 25,311,376 bp
  • A to T, chromosome 7 at 141,016,143 bp
  • T to A, chromosome 8 at 128,821,120 bp
  • T to A, chromosome 9 at 24,254,618 bp
  • T to A, chromosome 9 at 39,646,747 bp
  • A to G, chromosome 9 at 50,650,857 bp
  • A to G, chromosome 10 at 5,102,406 bp
  • T to A, chromosome 10 at 61,225,452 bp
  • T to C, chromosome 11 at 85,025,686 bp
  • A to G, chromosome 11 at 101,325,361 bp
  • A to G, chromosome 12 at 53,025,816 bp
  • A to G, chromosome 12 at 75,716,294 bp
  • A to G, chromosome 12 at 81,918,871 bp
  • T to C, chromosome 13 at 56,804,687 bp
  • T to C, chromosome 15 at 11,389,699 bp
  • T to A, chromosome 15 at 53,885,952 bp
  • A to G, chromosome 15 at 57,938,029 bp
  • T to C, chromosome 15 at 77,404,333 bp
  • C to A, chromosome 16 at 48,982,083 bp
  • C to T, chromosome 17 at 30,635,666 bp
  • C to A, chromosome 17 at 64,714,635 bp
  • T to C, chromosome 19 at 5,054,886 bp
  • A to G, chromosome 19 at 38,113,664 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6778 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044894-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.