Strain Name:
C57BL/6J-MtgxR6824Btlr/Mmmh
Stock Number:
044936-MU
Citation ID:
RRID:MMRRC_044936-MU
Other Names:
R6824 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: Ptprz, Ptpz, Rptpbeta, RPTPz, DSD-1-PG, PTPbeta, phosphacan, PTPzeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Adck2
Name: aarF domain containing kinase 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 57869
Homologene: 49103
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53890
Homologene: 40977
Emsy
Name: EMSY, BRCA2-interacting transcriptional repressor
Synonyms: 2210018M11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233545
Homologene: 32465
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: CMP-sialic acid synthetase, D6Bwg0250e, CMP-Neu5Ac synthase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12764
Homologene: 7670
Gps1
Name: G protein pathway suppressor 1
Synonyms: COPS1, Csn1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 209318
HGNC: HGNC:4549
Homologene: 3046
Tbc1d1
Name: TBC1 domain family, member 1
Synonyms: Nob1, Nobq1, 1110062G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57915
Homologene: 56856
Chn2
Name: chimerin 2
Synonyms: 4930557O16Rik, 1700026N20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69993
HGNC: HGNC:1944
Homologene: 31213
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Recql5
Name: RecQ protein-like 5
Synonyms: Recq5b, Recql5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Snap29
Name: synaptosomal-associated protein 29
Synonyms: 1300018G05Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67474
Homologene: 3512
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Dnajc27
Name: DnaJ heat shock protein family (Hsp40) member C27
Synonyms: C330021A05Rik, Rbj, Rabj
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217378
VEGA: 12
Homologene: 9558
Dach1
Name: dachshund family transcription factor 1
Synonyms: E130112M23Rik, Dac
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13134
HGNC: HGNC:2663
Homologene: 7288
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270118
Homologene: 134147
Stk10
Name: serine/threonine kinase 10
Synonyms: Gek1, Lok
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20868
Homologene: 38122
Sdk2
Name: sidekick cell adhesion molecule 2
Synonyms: 4632412F08Rik, 5330435L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237979
Homologene: 10406
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Synonyms: MB67, CAR, Care2, CAR1, mCAR, ESTM32
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12355
HGNC: HGNC:7969
Homologene: 3759
Or13n4
Name: olfactory receptor family 13 subfamily N member 4
Synonyms: MOR260-4, Olfr702, GA_x6K02T2PBJ9-9202245-9201289
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258590
Homologene: 121512
Zfp941
Name: zinc finger protein 941
Synonyms: BC066028
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 407812
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: EG637873, Gprc2a-rs2, Casr-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Chl1
Name: cell adhesion molecule L1-like
Synonyms: LICAM2, CALL, close homolog of L1, A530023M13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: GluRgamma2, KA2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Cdh4
Name: cadherin 4
Synonyms: R-cadherin, Rcad, R-Cadh
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214568
Homologene: 79759
Nrdc
Name: nardilysin convertase
Synonyms: NRD-C, Nrd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230598
HGNC: HGNC:7995
Homologene: 68260
Rnf180
Name: ring finger protein 180
Synonyms: 3110001E11Rik, Rines
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71816
VEGA: 13
Homologene: 18677
Tmem67
Name: transmembrane protein 67
Synonyms: b2b1291.1Clo, 5330408M12Rik, b2b1163.1Clo
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329795
Homologene: 71886
Krt8
Name: keratin 8
Synonyms: Card2, Krt-2.8, EndoA, cytokeratin 8, K8, cytokeratin8, Krt2-8, cytokeratin-8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16691
VEGA: 15
HGNC: HGNC:6446
Homologene: 55643
Ctif
Name: CBP80/20-dependent translation initiation factor
Synonyms: Gm672, LOC269037
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269037
VEGA: 18
Homologene: 56682
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: Nhe9, 5730527A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Cyth3
Name: cytohesin 3
Synonyms: Grp1, Pscd3, cytohesin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19159
HGNC: HGNC:9504
Homologene: 3116
Spaca1
Name: sperm acrosome associated 1
Synonyms: 1700124L11Rik, 4930540L03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67652
Homologene: 12170
Tcerg1l
Name: transcription elongation regulator 1-like
Synonyms: 5730476P14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70571
Homologene: 52165
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Fam50b
Name: family with sequence similarity 50, member B
Synonyms: D0H6S2654E, XAP-5-like, X5L
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 108161
VEGA: 13
Homologene: 101669
Ttll12
Name: tubulin tyrosine ligase-like family, member 12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223723
Homologene: 9036
Mrpl9
Name: mitochondrial ribosomal protein L9
Synonyms: 8030480E20Rik, C330013D18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78523
Homologene: 12696
Nicol1
Name: NELL2 interacting cell ontogeny regulator 1
Synonyms: LOC381633, Gm1673
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381633
Homologene: 134513
Pcdhb20
Name: protocadherin beta 20
Synonyms: Pcdhb14, PcdhbT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93891
HGNC: HGNC:8685
Homologene: 134303
Pde6d
Name: phosphodiesterase 6D, cGMP-specific, rod, delta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18582
HGNC: HGNC:8788
Homologene: 1954
Lad1
Name: ladinin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16763
HGNC: HGNC:6472
Homologene: 4059
Defb6
Name: defensin beta 6
Synonyms: mBD-6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 116746
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 86,545,763 bp
  • A to G, chromosome 1 at 135,827,741 bp
  • T to C, chromosome 1 at 171,214,973 bp
  • G to A, chromosome 2 at 179,797,558 bp
  • T to A, chromosome 3 at 38,957,525 bp
  • C to A, chromosome 3 at 94,443,370 bp
  • T to C, chromosome 4 at 12,051,449 bp
  • A to G, chromosome 4 at 34,049,869 bp
  • G to A, chromosome 4 at 34,746,591 bp
  • A to G, chromosome 4 at 109,043,425 bp
  • T to C, chromosome 5 at 33,983,725 bp
  • A to G, chromosome 5 at 64,256,902 bp
  • C to T, chromosome 5 at 113,744,539 bp
  • T to C, chromosome 5 at 143,686,510 bp
  • A to T, chromosome 6 at 23,002,131 bp
  • A to G, chromosome 6 at 39,575,124 bp
  • A to T, chromosome 6 at 54,272,953 bp
  • A to G, chromosome 6 at 103,714,549 bp
  • A to G, chromosome 6 at 142,771,236 bp
  • C to T, chromosome 7 at 25,046,355 bp
  • A to G, chromosome 7 at 30,586,276 bp
  • G to T, chromosome 7 at 42,299,979 bp
  • G to A, chromosome 7 at 98,593,407 bp
  • A to T, chromosome 7 at 105,406,829 bp
  • A to G, chromosome 7 at 106,824,457 bp
  • A to G, chromosome 7 at 138,394,115 bp
  • G to A, chromosome 7 at 140,812,699 bp
  • T to C, chromosome 8 at 19,228,083 bp
  • G to A, chromosome 9 at 13,697,217 bp
  • C to T, chromosome 9 at 95,227,198 bp
  • T to A, chromosome 10 at 21,145,120 bp
  • T to C, chromosome 11 at 32,587,363 bp
  • T to C, chromosome 11 at 113,867,934 bp
  • C to T, chromosome 11 at 115,923,212 bp
  • T to C, chromosome 11 at 120,787,428 bp
  • T to C, chromosome 12 at 4,106,897 bp
  • G to A, chromosome 13 at 34,747,101 bp
  • T to A, chromosome 13 at 105,181,515 bp
  • A to T, chromosome 14 at 57,613,403 bp
  • A to G, chromosome 14 at 98,018,892 bp
  • A to T, chromosome 15 at 83,591,377 bp
  • T to C, chromosome 15 at 101,998,440 bp
  • A to G, chromosome 16 at 17,422,506 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to A, chromosome 18 at 37,505,699 bp
  • C to T, chromosome 18 at 75,521,711 bp
  • T to C, chromosome 19 at 8,826,717 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6824 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044936-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.