Strain Name:
C57BL/6J-MtgxR6838Btlr/Mmmh
Stock Number:
044946-MU
Citation ID:
RRID:MMRRC_044946-MU
Other Names:
R6838 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: MVa, Myo5, flail, 9630007J19Rik, MyoVA, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Gpx1
Name: glutathione peroxidase 1
Synonyms: Gpx, GSHPx-1, GPx-1, CGPx, cellular GPx
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14775
HGNC: HGNC:4553
Homologene: 20155
Tpst1
Name: protein-tyrosine sulfotransferase 1
Synonyms: Tango13a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22021
Homologene: 2667
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Map4k4
Name: mitogen-activated protein kinase kinase kinase kinase 4
Synonyms: Nik, 9430080K19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26921
HGNC: HGNC:6866
Homologene: 7442
Bms1
Name: BMS1, ribosome biogenesis factor
Synonyms: Bms1l
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213895
Homologene: 7065
Ppp1r12a
Name: protein phosphatase 1, regulatory subunit 12A
Synonyms: Mypt1, 5730577I22Rik, D10Ertd625e, 1200015F06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17931
VEGA: 10
HGNC: HGNC:7618
Homologene: 1855
Tango6
Name: transport and golgi organization 6
Synonyms: Tmco7, Tango6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F37S1, D7H15F32S1, rjs, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
Evi5
Name: ecotropic viral integration site 5
Synonyms: NB4S
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14020
HGNC: HGNC:3501
Homologene: 121902
Ddx46
Name: DEAD box helicase 46
Synonyms: 8430438J23Rik, 2200005K02Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 212880
VEGA: 13
Homologene: 5430
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: Pcp-1, Pcp1, IP3R1, InsP3R type I, P400, Ip3r, opt, wblo, Itpr-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Ereg
Name: epiregulin
Synonyms: EPR
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13874
HGNC: HGNC:3443
Homologene: 1097
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381314
Homologene: 7118
Cand1
Name: cullin associated and neddylation disassociated 1
Synonyms: D10Ertd516e, 2310038O07Rik, 6330512O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71902
Homologene: 10202
C2cd5
Name: C2 calcium-dependent domain containing 5
Synonyms: C030008B15Rik, CDP138, 5730419I09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74741
Homologene: 8873
Cdin1
Name: CDAN1 interacting nuclease 1
Synonyms: BC052040
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 399568
Homologene: 32780
Hk1
Name: hexokinase 1
Synonyms: Hk-1, mHk1-s, Hk1-s
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Tnnt1
Name: troponin T1, skeletal, slow
Synonyms: Tnt, ssTnT, sTnT, skeletal muscle slow-twitch TnT
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21955
Homologene: 20704
Mex3a
Name: mex3 RNA binding family member A
Synonyms: 2700083E18Rik, Rkhd4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72640
Homologene: 18950
Avil
Name: advillin
Synonyms: DOC6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11567
Homologene: 38200
Invs
Name: inversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16348
Homologene: 7786
Rab38
Name: RAB38, member RAS oncogene family
Synonyms: 2310011F14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72433
HGNC: HGNC:9776
Homologene: 21353
Aqp9
Name: aquaporin 9
Synonyms: 1700020I22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 64008
HGNC: HGNC:643
Homologene: 41405
Ism2
Name: isthmin 2
Synonyms: Thsd3, LOC217738
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217738
Homologene: 83509
Bbs1
Name: Bardet-Biedl syndrome 1
Synonyms: D19Ertd609e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Cd180
Name: CD180 antigen
Synonyms: Ly78, RP105
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Kif17
Name: kinesin family member 17
Synonyms: Kif17b, 5930435E01Rik, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16559
Homologene: 5883
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MAPKAP kinase 2, MK2, Rps6kc1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Or8b12b
Name: olfactory receptor family 8 subfamily B member 12B
Synonyms: GA_x6K02T2PVTD-31458511-31459443, MOR161-4, Olfr875
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258744
Homologene: 121527
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Tbc1d17
Name: TBC1 domain family, member 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233204
Homologene: 11656
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241116
Homologene: 28093
Frem3
Name: Fras1 related extracellular matrix protein 3
Synonyms: LOC333315
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 333315
Homologene: 35388
Obox6
Name: oocyte specific homeobox 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 252830
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238803
Homologene: 17637
Spata22
Name: spermatogenesis associated 22
Synonyms: LOC380709
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380709
Homologene: 13076
Gramd1a
Name: GRAM domain containing 1A
Synonyms: D7Bwg0611e, 1300003M23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52857
Homologene: 10843
Bscl2
Name: BSCL2 lipid droplet biogenesis associated, seipin
Synonyms: seipin, Gng3lg
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14705
Homologene: 32032
Aim2
Name: absent in melanoma 2
Synonyms: Ifi210, LOC383619
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383619
HGNC: HGNC:357
Homologene: 83226
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, Nlrc2, F830032C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
P3h2
Name: prolyl 3-hydroxylase 2
Synonyms: Leprel1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210530
Homologene: 10062
Lvrn
Name: laeverin
Synonyms: Aqpep, 4833403I15Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74574
VEGA: 18
Homologene: 51352
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245174
Homologene: 136215
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74549
Homologene: 12574
Nol3
Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
Synonyms: ARC, B430311C09Rik, Nop30
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78688
HGNC: HGNC:7869
Homologene: 31208
Mapk13
Name: mitogen-activated protein kinase 13
Synonyms: p38 delta MAP kinase, Serk4, SAPK4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26415
HGNC: HGNC:6875
Homologene: 48133
Or2h1
Name: olfactory receptor family 2 subfamily H member 1
Synonyms: Olfr91, GA_x6K02T2PSCP-1533927-1532989, MOR256-20
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258470
HGNC: HGNC:8252
Homologene: 72346
Septin1
Name: septin 1
Synonyms: Sept1, PNUTL3, Diff6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54204
HGNC: HGNC:2879
Homologene: 23009
Cracd
Name: capping protein inhibiting regulator of actin
Synonyms: C530008M17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320827
Homologene: 136278
H4c12
Name: H4 clustered histone 12
Synonyms: Hist1h4k
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319160
Homologene: 134461
Xndc1
Name: Xrcc1 N-terminal domain containing 1
Synonyms: Xndr
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 102443350
Homologene: 128476
Vmn1r257
Name: vomeronasal 1 receptor 257
Synonyms: Gm4144, Gm8693
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667543
Homologene: 104166
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 39,976,722 bp
  • T to C, chromosome 1 at 46,191,788 bp
  • T to C, chromosome 1 at 74,932,021 bp
  • T to A, chromosome 1 at 131,058,003 bp
  • C to T, chromosome 1 at 136,084,437 bp
  • C to G, chromosome 1 at 173,463,980 bp
  • G to A, chromosome 1 at 185,329,145 bp
  • A to T, chromosome 1 at 194,804,914 bp
  • T to C, chromosome 2 at 115,776,990 bp
  • T to A, chromosome 2 at 150,239,346 bp
  • A to G, chromosome 3 at 88,536,777 bp
  • C to T, chromosome 4 at 48,283,278 bp
  • A to T, chromosome 4 at 138,278,399 bp
  • A to G, chromosome 5 at 38,530,031 bp
  • A to T, chromosome 5 at 76,632,215 bp
  • A to T, chromosome 5 at 76,858,209 bp
  • A to G, chromosome 5 at 91,088,464 bp
  • G to T, chromosome 5 at 107,842,161 bp
  • A to T, chromosome 5 at 130,102,438 bp
  • G to T, chromosome 6 at 12,504,075 bp
  • T to C, chromosome 6 at 108,471,191 bp
  • A to G, chromosome 6 at 118,416,494 bp
  • A to G, chromosome 6 at 143,029,638 bp
  • T to C, chromosome 7 at 4,507,407 bp
  • T to C, chromosome 7 at 15,833,739 bp
  • T to A, chromosome 7 at 22,691,717 bp
  • T to C, chromosome 7 at 31,134,504 bp
  • C to A, chromosome 7 at 44,844,314 bp
  • T to A, chromosome 7 at 56,108,778 bp
  • A to G, chromosome 7 at 88,450,709 bp
  • T to C, chromosome 7 at 102,073,269 bp
  • T to C, chromosome 7 at 127,216,722 bp
  • A to T, chromosome 8 at 70,039,297 bp
  • A to C, chromosome 8 at 80,612,031 bp
  • A to C, chromosome 8 at 88,670,458 bp
  • A to T, chromosome 8 at 105,279,575 bp
  • A to G, chromosome 8 at 106,742,074 bp
  • A to C, chromosome 9 at 37,773,052 bp
  • T to A, chromosome 9 at 49,000,430 bp
  • T to A, chromosome 9 at 71,112,216 bp
  • T to C, chromosome 9 at 75,153,883 bp
  • A to G, chromosome 9 at 108,339,940 bp
  • T to C, chromosome 10 at 62,271,658 bp
  • C to T, chromosome 10 at 108,261,276 bp
  • T to C, chromosome 10 at 119,210,030 bp
  • G to A, chromosome 10 at 127,013,562 bp
  • A to T, chromosome 11 at 73,073,474 bp
  • C to T, chromosome 11 at 73,345,933 bp
  • A to T, chromosome 12 at 87,280,201 bp
  • A to T, chromosome 13 at 21,750,205 bp
  • G to T, chromosome 13 at 55,639,935 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • C to T, chromosome 13 at 99,228,507 bp
  • A to G, chromosome 13 at 99,246,177 bp
  • A to G, chromosome 13 at 102,702,731 bp
  • A to G, chromosome 14 at 31,354,173 bp
  • A to G, chromosome 14 at 121,546,596 bp
  • G to A, chromosome 15 at 85,939,194 bp
  • T to C, chromosome 16 at 26,105,284 bp
  • T to A, chromosome 16 at 90,782,106 bp
  • G to T, chromosome 17 at 28,777,561 bp
  • A to G, chromosome 17 at 30,710,551 bp
  • A to T, chromosome 17 at 37,093,166 bp
  • A to G, chromosome 18 at 46,890,880 bp
  • C to T, chromosome 19 at 4,903,852 bp
  • A to T, chromosome 19 at 8,841,381 bp
  • G to A, chromosome 19 at 27,247,970 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6838 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044946-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.