Strain Name:
C57BL/6J-MtgxR6856Btlr/Mmmh
Stock Number:
044958-MU
Citation ID:
RRID:MMRRC_044958-MU
Other Names:
R6856 (G1)
Major Collection:

Strain Information

Pax3
Name: paired box 3
Synonyms: Pax-3, Splchl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18505
HGNC: HGNC:8617
Homologene: 22494
Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Ptpra
Name: protein tyrosine phosphatase receptor type A
Synonyms: PTPalpha, Ptpa, RPTPalpha, RPTRalpha, PTP[a]
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19262
HGNC: HGNC:9664
Homologene: 20621
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 1190009E20Rik, 2410018I08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69727
Homologene: 56957
Rap1a
Name: RAS-related protein 1a
Synonyms: Rap1, Krev-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109905
HGNC: HGNC:9855
Homologene: 2162
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: B630009I04Rik, ASC1p200, Helic1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Cpt1c
Name: carnitine palmitoyltransferase 1c
Synonyms: 9630004I06Rik, CPT I-C
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78070
Homologene: 17561
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2d, Bat2l2, 9630039I18Rik, 1810043M20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: C330023M02Rik, 4833422K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, CS1, CS-1, SPAG13, KRAP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Fbxo32
Name: F-box protein 32
Synonyms: ATROGIN1, atrogin-1, 4833442G10Rik, MAFbx
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67731
VEGA: 15
Homologene: 12182
Plxnb2
Name: plexin B2
Synonyms: 1110007H23Rik, Debt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Anp32a
Name: acidic nuclear phosphoprotein 32 family member A
Synonyms: pp32, Anp32
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11737
Homologene: 137229
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: CD9P-1, 4833445A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Eltd1, 1110033N21Rik, Etl, EGF-TM7 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Gask1b
Name: golgi associated kinase 1B
Synonyms: Fam198b, 2210419I08Rik, Ened, 1110032E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68659
Homologene: 9590
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Stk11
Name: serine/threonine kinase 11
Synonyms: Par-4, Lkb1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20869
Homologene: 393
Atad2
Name: ATPase family, AAA domain containing 2
Synonyms: 2610509G12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70472
VEGA: 15
Homologene: 6044
Slmap
Name: sarcolemma associated protein
Synonyms: Miranda, D330001L02Rik, Slap
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 83997
Homologene: 31428
Trim33
Name: tripartite motif-containing 33
Synonyms: ectodermin, Ecto, 8030451N04Rik, Tif1g
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94093
Homologene: 9296
Dhx29
Name: DExH-box helicase 29
Synonyms: DEAH (Asp-Glu-Ala-His) box polypeptide 29, E130202M19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218629
VEGA: 13
Homologene: 10387
Aqp4
Name: aquaporin 4
Synonyms: aquaporin-4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11829
VEGA: 18
HGNC: HGNC:637
Homologene: 37507
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nerg1, mGluR6, nob3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Map4k1
Name: mitogen-activated protein kinase kinase kinase kinase 1
Synonyms: Hpk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26411
HGNC: HGNC:6863
Homologene: 5199
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23954
HGNC: HGNC:7746
Homologene: 1869
Zfp385b
Name: zinc finger protein 385B
Synonyms: B830010L13Rik, Zfp533, C130013B13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241494
Homologene: 17606
Trpv2
Name: transient receptor potential cation channel, subfamily V, member 2
Synonyms: VRL-1, Vrl1, OTRPC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22368
Homologene: 7993
Zfp839
Name: zinc finger protein 839
Synonyms: 2810455K09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72805
VEGA: 12
Homologene: 49541
Ccr6
Name: C-C motif chemokine receptor 6
Synonyms: Cmkbr6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12458
VEGA: 17
HGNC: HGNC:1607
Homologene: 3214
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Nup210
Name: nucleoporin 210
Synonyms: gp190, Pom210, gp210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Or52d1
Name: olfactory receptor family 52 subfamily D member 1
Synonyms: GA_x6K02T2PBJ9-6841330-6842268, Olfr646, MOR33-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259058
Homologene: 17481
Vmn1r27
Name: vomeronasal 1 receptor 27
Synonyms: V1rc33
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171206
Homologene: 79462
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Noxred1
Name: NADP+ dependent oxidoreductase domain containing 1
Synonyms: 4933437F05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71275
VEGA: 12
Homologene: 51388
Or8k27
Name: olfactory receptor family 8 subfamily K member 27
Synonyms: Olfr1065, GA_x6K02T2Q125-47915274-47914333, MOR190-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258403
Homologene: 74195
Capn9
Name: calpain 9
Synonyms: GC36, nCL-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73647
HGNC: HGNC:1486
Homologene: 38208
Zfp109
Name: zinc finger protein 109
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56869
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Pygm
Name: muscle glycogen phosphorylase
Synonyms: PG
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19309
HGNC: HGNC:9726
Homologene: 2145
Prpsap2
Name: phosphoribosyl pyrophosphate synthetase-associated protein 2
Synonyms: A230054F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 212627
HGNC: HGNC:9467
Homologene: 2073
Tmem232
Name: transmembrane protein 232
Synonyms: E130009J12Rik, LOC381107
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381107
VEGA: 17
Homologene: 54378
Krt36
Name: keratin 36
Synonyms: HRa-1, keratin 5, Krt1-5, Krt1-22
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16673
HGNC: HGNC:6454
Homologene: 88459
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Erg
Name: ETS transcription factor
Synonyms: D030036I24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13876
HGNC: HGNC:3446
Homologene: 15848
Ldhd
Name: lactate dehydrogenase D
Synonyms: 4733401P21Rik, D8Bwg1320e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52815
Homologene: 5536
Glis1
Name: GLIS family zinc finger 1
Synonyms: GliH1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230587
Homologene: 77390
Spdye4c
Name: speedy/RINGO cell cycle regulator family, member E4C
Synonyms: Gm355, LOC241634
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241634
Homologene: 78093
Gtf3c6
Name: general transcription factor IIIC, polypeptide 6, alpha
Synonyms: 2410016F19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67371
VEGA: 10
Homologene: 12121
Pcdhgb5
Name: protocadherin gamma subfamily B, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93702
HGNC: HGNC:8712
Homologene: 55773
Igkv12-41
Name: immunoglobulin kappa chain variable 12-41
Synonyms: Gm16848
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619960
Speer4a3
Name: spermatogenesis associated glutamate (E)-rich protein 4A3
Synonyms: Gm21671
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862359
Homologene: 69402
Cfap99
Name: cilia and flagella associated protein 99
Synonyms: Gm21446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862066
Homologene: 82544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 78,132,419 bp
  • A to T, chromosome 1 at 105,553,895 bp
  • T to C, chromosome 1 at 140,596,004 bp
  • A to G, chromosome 1 at 162,682,371 bp
  • A to T, chromosome 2 at 69,513,268 bp
  • T to A, chromosome 2 at 77,415,794 bp
  • C to T, chromosome 2 at 79,657,705 bp
  • G to T, chromosome 2 at 86,445,907 bp
  • A to G, chromosome 2 at 128,596,130 bp
  • G to A, chromosome 2 at 130,519,381 bp
  • G to T, chromosome 3 at 79,886,141 bp
  • T to C, chromosome 3 at 101,045,446 bp
  • C to T, chromosome 3 at 103,352,049 bp
  • A to G, chromosome 3 at 105,732,068 bp
  • A to G, chromosome 3 at 151,500,118 bp
  • T to G, chromosome 4 at 107,435,879 bp
  • A to G, chromosome 5 at 25,950,845 bp
  • G to T, chromosome 5 at 34,310,217 bp
  • A to G, chromosome 5 at 74,028,934 bp
  • A to T, chromosome 5 at 121,438,804 bp
  • C to A, chromosome 5 at 150,540,208 bp
  • T to A, chromosome 6 at 58,215,447 bp
  • A to T, chromosome 6 at 69,858,529 bp
  • G to A, chromosome 6 at 91,087,913 bp
  • G to T, chromosome 6 at 125,642,150 bp
  • A to T, chromosome 7 at 24,229,398 bp
  • A to T, chromosome 7 at 28,986,834 bp
  • C to T, chromosome 7 at 44,959,918 bp
  • T to A, chromosome 7 at 45,794,297 bp
  • A to T, chromosome 7 at 104,106,791 bp
  • C to A, chromosome 8 at 22,129,447 bp
  • A to G, chromosome 8 at 111,630,274 bp
  • G to A, chromosome 8 at 124,597,569 bp
  • T to C, chromosome 9 at 49,420,020 bp
  • A to T, chromosome 9 at 62,372,115 bp
  • A to G, chromosome 9 at 66,397,898 bp
  • T to C, chromosome 10 at 40,249,672 bp
  • T to A, chromosome 10 at 50,749,062 bp
  • A to T, chromosome 10 at 78,030,255 bp
  • C to A, chromosome 10 at 80,128,090 bp
  • G to A, chromosome 11 at 50,168,746 bp
  • A to T, chromosome 11 at 50,859,825 bp
  • A to T, chromosome 11 at 61,730,271 bp
  • A to C, chromosome 11 at 62,584,615 bp
  • T to G, chromosome 11 at 100,103,390 bp
  • T to C, chromosome 12 at 87,227,036 bp
  • T to A, chromosome 12 at 110,866,761 bp
  • A to T, chromosome 13 at 112,952,861 bp
  • A to T, chromosome 14 at 26,430,092 bp
  • T to A, chromosome 15 at 58,106,813 bp
  • G to A, chromosome 15 at 58,214,641 bp
  • A to C, chromosome 15 at 89,164,320 bp
  • C to A, chromosome 16 at 95,368,651 bp
  • T to A, chromosome 17 at 8,256,049 bp
  • T to C, chromosome 17 at 24,573,493 bp
  • G to A, chromosome 17 at 65,450,310 bp
  • T to C, chromosome 18 at 15,399,896 bp
  • G to A, chromosome 18 at 20,601,802 bp
  • T to A, chromosome 18 at 37,733,404 bp
  • A to G, chromosome 18 at 37,979,863 bp
  • C to T, chromosome 18 at 49,852,288 bp
  • G to T, chromosome 19 at 6,393,757 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6856 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044958-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.