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Strain Name:
C57BL/6J-MtgxR6863Btlr/Mmmh
Stock Number:
044963-MU
Citation ID:
RRID:MMRRC_044963-MU
Other Names:
R6863 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Cdkn2a
Name: cyclin dependent kinase inhibitor 2A
Synonyms: MTS1, p19ARF, p16INK4a, INK4a-ARF, p16, ARF-INK4a, Arf, Pctr1, p19ARF, Ink4a/Arf
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12578
HGNC: HGNC:1787
Homologene: 55430
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Rad54l
Name: RAD54 like (S. cerevisiae)
Synonyms: RAD54
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19366
HGNC: HGNC:9826
Homologene: 48227
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 14,270,975 bp
  • T to C, chromosome 1 at 97,646,305 bp
  • T to A, chromosome 2 at 3,305,304 bp
  • A to G, chromosome 2 at 20,806,309 bp
  • T to C, chromosome 2 at 62,787,685 bp
  • G to A, chromosome 2 at 177,194,067 bp
  • A to G, chromosome 4 at 45,458,163 bp
  • T to C, chromosome 4 at 89,274,766 bp
  • T to C, chromosome 4 at 116,099,669 bp
  • A to T, chromosome 4 at 132,789,596 bp
  • T to A, chromosome 4 at 138,269,884 bp
  • A to T, chromosome 4 at 139,669,719 bp
  • A to T, chromosome 5 at 24,452,463 bp
  • C to A, chromosome 5 at 24,452,464 bp
  • A to T, chromosome 5 at 96,543,306 bp
  • T to C, chromosome 5 at 139,151,596 bp
  • T to C, chromosome 5 at 142,815,197 bp
  • A to T, chromosome 6 at 40,729,009 bp
  • A to G, chromosome 7 at 43,676,622 bp
  • T to A, chromosome 7 at 88,302,278 bp
  • C to T, chromosome 7 at 103,346,916 bp
  • C to T, chromosome 7 at 126,871,937 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • G to A, chromosome 8 at 17,534,913 bp
  • G to T, chromosome 8 at 45,044,464 bp
  • A to T, chromosome 8 at 64,823,091 bp
  • T to C, chromosome 8 at 70,770,414 bp
  • C to T, chromosome 8 at 93,317,019 bp
  • T to C, chromosome 8 at 105,285,803 bp
  • C to A, chromosome 9 at 20,348,499 bp
  • T to G, chromosome 9 at 26,881,064 bp
  • A to G, chromosome 9 at 40,074,814 bp
  • T to C, chromosome 9 at 65,035,008 bp
  • A to G, chromosome 9 at 107,920,026 bp
  • C to A, chromosome 10 at 34,092,455 bp
  • C to A, chromosome 10 at 53,349,118 bp
  • T to A, chromosome 10 at 57,808,011 bp
  • G to T, chromosome 10 at 80,017,782 bp
  • T to C, chromosome 10 at 81,347,020 bp
  • T to A, chromosome 11 at 17,953,794 bp
  • T to C, chromosome 11 at 20,314,001 bp
  • T to C, chromosome 11 at 30,146,777 bp
  • C to G, chromosome 11 at 46,815,443 bp
  • T to A, chromosome 11 at 54,546,380 bp
  • A to G, chromosome 12 at 8,990,047 bp
  • A to T, chromosome 12 at 16,684,420 bp
  • T to C, chromosome 12 at 88,321,198 bp
  • G to T, chromosome 12 at 100,061,689 bp
  • T to C, chromosome 12 at 108,702,202 bp
  • T to C, chromosome 12 at 110,652,180 bp
  • A to C, chromosome 14 at 30,075,852 bp
  • G to T, chromosome 14 at 37,071,944 bp
  • A to T, chromosome 14 at 61,360,302 bp
  • A to T, chromosome 15 at 94,379,746 bp
  • T to C, chromosome 15 at 96,419,419 bp
  • T to A, chromosome 17 at 34,923,822 bp
  • C to A, chromosome 17 at 56,183,789 bp
  • T to C, chromosome 19 at 9,012,365 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6863 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044963-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.