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Strain Name:
C57BL/6J-MtgxR6873Btlr/Mmmh
Stock Number:
044970-MU
Citation ID:
RRID:MMRRC_044970-MU
Other Names:
R6873 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Mon1b
Name: MON1 homolog B, secretory traffciking associated
Synonyms: 5033413H12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270096
Homologene: 69174
Krt5
Name: keratin 5
Synonyms: K5, 3300001P10Rik, Tfip8, Krt2-5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110308
HGNC: HGNC:6442
Homologene: 55461
Galnt10
Name: polypeptide N-acetylgalactosaminyltransferase 10
Synonyms: GalNAc-T10, Galnt9, C330012K04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171212
Homologene: 14924
Uri1
Name: URI1, prefoldin-like chaperone
Synonyms: NNX3, Rmp, C80913
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19777
Homologene: 2813
Nlk
Name: nemo like kinase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18099
Homologene: 88836
Tm9sf2
Name: transmembrane 9 superfamily member 2
Synonyms: P76, 1500001N15Rik, D14Ertd64e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68059
Homologene: 21004
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 9130422G05Rik, 1810054D07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 208618
Homologene: 10477
Atp5f1a
Name: ATP synthase F1 subunit alpha
Synonyms: Atpm, D18Ertd206e, Mom2, Atp5a1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11946
HGNC: HGNC:823
Homologene: 2985
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Synonyms: Hif1b, ESTM42, D3Ertd557e, bHLHe2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11863
HGNC: HGNC:700
Homologene: 1261
Dctn2
Name: dynactin 2
Synonyms: RBP50, DCTN-50, p50, 2310042E05Rik, C130077D06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69654
VEGA: 10
HGNC: HGNC:2712
Homologene: 4667
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv-2, Ron, CDw136, friend virus susceptibility 2, PTK8, Fv2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Mef2b
Name: myocyte enhancer factor 2B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17259
Homologene: 48381
Col11a2
Name: collagen, type XI, alpha 2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12815
HGNC: HGNC:2187
Homologene: 22547
Tmem209
Name: transmembrane protein 209
Synonyms: 2700094F01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72649
Homologene: 18021
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 192188
Homologene: 23022
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20957
Homologene: 2389
Mast3
Name: microtubule associated serine/threonine kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 546071
Homologene: 66191
Caskin1
Name: CASK interacting protein 1
Synonyms: C630036E02Rik, 3300002N10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Igsf10
Name: immunoglobulin superfamily, member 10
Synonyms: 6530405F15Rik, CMF608, Adlican2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242050
Homologene: 18712
Pfkfb4
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270198
HGNC: HGNC:8875
Homologene: 48288
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: 1700028B15Rik, Afaf, equatorin, 4930579C15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Or1j12
Name: olfactory receptor family 1 subfamily J member 12
Synonyms: GA_x6K02T2NLDC-33147742-33148680, MOR136-1, Olfr340
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258953
Homologene: 74159
Adss1
Name: adenylosuccinate synthase 1
Synonyms: Adss, Adssl1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11565
VEGA: 12
Homologene: 111992
Sh3bgr
Name: SH3-binding domain glutamic acid-rich protein
Synonyms: 5430437A18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50795
Homologene: 56376
Or2n1
Name: olfactory receptor family 2 subfamily N member 1
Synonyms: MOR256-5, GA_x6K02T2PSCP-2623613-2624551, Olfr134
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258829
Homologene: 110603
Slc35c2
Name: solute carrier family 35, member C2
Synonyms: D2Wsu58e, CGI-15, Ovcov1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228875
Homologene: 6581
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Spata13
Name: spermatogenesis associated 13
Synonyms: ESTM11
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219140
Homologene: 19482
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: EG434264, Gm15438
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434264
Homologene: 37741
Lancl2
Name: LanC (bacterial lantibiotic synthetase component C)-like 2
Synonyms: 1700003F10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71835
HGNC: HGNC:6509
Homologene: 23116
Tspan10
Name: tetraspanin 10
Synonyms: Ocsp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 208634
Homologene: 49972
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Nhlrc4
Name: NHL repeat containing 4
Synonyms: F430201B04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 621239
Homologene: 134625
Calhm5
Name: calcium homeostasis modulator family member 5
Synonyms: Fam26e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103511
VEGA: 10
Homologene: 17807
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269529
Homologene: 19544
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Bhlha15
Name: basic helix-loop-helix family, member a15
Synonyms: 1810009C13Rik, Mist1, Bhlhb8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17341
Homologene: 7838
Grap2
Name: GRB2-related adaptor protein 2
Synonyms: Gads, Grb2-related adaptor downstream of Sch, GRID, GRAP-2, GrbX, GRB2L, Grf40, P38, Mona, GrpL
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17444
VEGA: 15
HGNC: HGNC:4563
Homologene: 21007
Gm6309
Name: predicted gene 6309
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 622306
Homologene: 86127
Gm13762
Name: predicted gene 13762
Type: Gene
Species: Mouse
Chromosome: 2
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 20,797,992 bp
  • A to T, chromosome 2 at 36,453,496 bp
  • T to C, chromosome 2 at 88,973,424 bp
  • T to C, chromosome 2 at 165,282,809 bp
  • T to A, chromosome 2 at 166,089,275 bp
  • C to T, chromosome 3 at 59,328,444 bp
  • T to G, chromosome 3 at 95,474,575 bp
  • G to A, chromosome 3 at 102,840,980 bp
  • T to C, chromosome 4 at 45,041,787 bp
  • G to C, chromosome 4 at 83,246,276 bp
  • A to G, chromosome 4 at 94,927,021 bp
  • A to G, chromosome 4 at 111,566,659 bp
  • A to G, chromosome 5 at 144,191,385 bp
  • T to C, chromosome 5 at 146,168,188 bp
  • A to G, chromosome 6 at 30,508,456 bp
  • A to G, chromosome 6 at 57,722,657 bp
  • A to T, chromosome 7 at 13,625,386 bp
  • A to T, chromosome 7 at 37,965,339 bp
  • A to G, chromosome 7 at 75,206,206 bp
  • T to C, chromosome 7 at 140,923,520 bp
  • A to G, chromosome 8 at 70,166,307 bp
  • A to T, chromosome 8 at 70,786,592 bp
  • C to T, chromosome 8 at 108,800,641 bp
  • T to C, chromosome 8 at 113,642,065 bp
  • A to T, chromosome 9 at 15,010,217 bp
  • A to T, chromosome 9 at 107,911,644 bp
  • A to C, chromosome 9 at 109,010,335 bp
  • G to C, chromosome 10 at 34,092,452 bp
  • A to G, chromosome 10 at 86,861,366 bp
  • T to G, chromosome 10 at 127,276,236 bp
  • A to G, chromosome 11 at 57,781,219 bp
  • A to G, chromosome 11 at 78,590,948 bp
  • T to C, chromosome 11 at 120,444,723 bp
  • G to T, chromosome 12 at 8,015,995 bp
  • A to G, chromosome 12 at 112,632,704 bp
  • T to A, chromosome 14 at 60,691,957 bp
  • A to T, chromosome 14 at 122,145,113 bp
  • A to G, chromosome 15 at 4,790,979 bp
  • G to A, chromosome 15 at 80,643,673 bp
  • G to A, chromosome 15 at 101,712,877 bp
  • A to C, chromosome 16 at 96,206,491 bp
  • A to G, chromosome 17 at 24,504,179 bp
  • G to A, chromosome 17 at 25,943,522 bp
  • A to G, chromosome 17 at 34,065,019 bp
  • A to T, chromosome 17 at 38,175,368 bp
  • C to T, chromosome 18 at 77,775,840 bp
  • A to G, chromosome 18 at 78,859,559 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6873 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044970-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.