Strain Name:
C57BL/6J-MtgxR6875Btlr/Mmmh
Stock Number:
044971-MU
Citation ID:
RRID:MMRRC_044971-MU
Other Names:
R6875 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Epha2
Name: Eph receptor A2
Synonyms: Sek-2, Eck, Sek2, Myk2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13836
HGNC: HGNC:3386
Homologene: 20929
Tiparp
Name: TCDD-inducible poly(ADP-ribose) polymerase
Synonyms: DDF1, PARP-7, PARP7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99929
Homologene: 9167
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, 2810019G02Rik, Ars2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Eif3l
Name: eukaryotic translation initiation factor 3, subunit L
Synonyms: PAF67, 0610011H21Rik, HSP-66Y, Eif3s6ip, Eif3eip, D15N1e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223691
VEGA: 15
Homologene: 9380
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Rab28
Name: RAB28, member RAS oncogene family
Synonyms: 2700023P08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100972
HGNC: HGNC:9768
Homologene: 3135
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik, d1401
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Cluh
Name: clustered mitochondria homolog
Synonyms: 1300001I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74148
Homologene: 9063
Ipo13
Name: importin 13
Synonyms: Kap13, Imp13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230673
Homologene: 40968
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74015
Homologene: 22869
Rrp36
Name: ribosomal RNA processing 36
Synonyms: BC011248
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224823
VEGA: 17
Homologene: 40346
Npnt
Name: nephronectin
Synonyms: POEM, 1110009H02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114249
Homologene: 14138
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Fgf23
Name: fibroblast growth factor 23
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 64654
HGNC: HGNC:3680
Homologene: 10771
Zfp317
Name: zinc finger protein 317
Synonyms: D230022C05Rik, KRAB9, Zfp75, Zfp67
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244713
Homologene: 36389
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Runx2
Name: runt related transcription factor 2
Synonyms: Cbfa1, Pebpa2a, AML3, polyomavirus enhancer binding factor 2 (PEBP2), PEBP2 alpha A, Osf2, SL3-3 enhancer factor 1, PEBP2aA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Il36g
Name: interleukin 36G
Synonyms: Il1f9, IL-36gamma, If36g
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215257
Homologene: 49595
Adam19
Name: ADAM metallopeptidase domain 19
Synonyms: Mltnb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11492
HGNC: HGNC:197
Homologene: 74925
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-beta, IKK-2, IKK2, IKK[b], IKKbeta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Rnft2
Name: ring finger protein, transmembrane 2
Synonyms: B830028P19Rik, Tmem118
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269695
Homologene: 41892
Phf21b
Name: PHD finger protein 21B
Synonyms: A730032D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271305
Homologene: 78154
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: Siglec5, mSiglec-F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Qrfprl
Name: pyroglutamylated RFamide peptide receptor like
Synonyms: C130060K24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243407
Homologene: 135976
Nr1d1
Name: nuclear receptor subfamily 1, group D, member 1
Synonyms: REV-ERBalpha, rev-erbA(alpha), A530070C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217166
HGNC: HGNC:7962
Homologene: 23324
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Atp10a
Name: ATPase, class V, type 10A
Synonyms: pfatp, Atp10c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11982
Homologene: 56461
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Catsper1
Name: cation channel, sperm associated 1
Synonyms: KSper
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225865
VEGA: 19
Homologene: 14207
Commd6
Name: COMM domain containing 6
Synonyms: 1700063H17Rik, 1110059J08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66200
Homologene: 52572
Slc22a1
Name: solute carrier family 22 (organic cation transporter), member 1
Synonyms: Orct, Oct1, Lx1, Orct1, Oct1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20517
VEGA: 17
Homologene: 20665
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, Nav1.5c, SkM2, mH1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Stard9
Name: StAR related lipid transfer domain containing 9
Synonyms: E230025N21Rik, Kif16a, 4831403C07Rik, N-3 kinesin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668880
Homologene: 130712
Nckap5
Name: NCK-associated protein 5
Synonyms: LOC380609, D130011D22Rik, E030049G20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210356
Homologene: 35542
Syt11
Name: synaptotagmin XI
Synonyms: 6530420C11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229521
Homologene: 23120
Prpsap1
Name: phosphoribosyl pyrophosphate synthetase-associated protein 1
Synonyms: PAP39, 5730409F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67763
HGNC: HGNC:9466
Homologene: 55687
Tulp2
Name: TUB like protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56734
Homologene: 2492
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 112417
Homologene: 137225
Hecw2
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Synonyms: D030049F17Rik, Nedl2, A730039N16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329152
Homologene: 66192
Flnc
Name: filamin C, gamma
Synonyms: Fln2, 1110055E19Rik, actin binding protein 280
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68794
HGNC: HGNC:3756
Homologene: 37481
Msrb3
Name: methionine sulfoxide reductase B3
Synonyms: D430026P16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320183
Homologene: 71327
Klhl25
Name: kelch-like 25
Synonyms: 2810402K13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207952
Homologene: 32546
Krt8
Name: keratin 8
Synonyms: K8, EndoA, cytokeratin-8, cytokeratin8, cytokeratin 8, Krt-2.8, Card2, Krt2-8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16691
VEGA: 15
HGNC: HGNC:6446
Homologene: 55643
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Zfp709
Name: zinc finger protein 709
Synonyms: GIOT-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 236193
Homologene: 136795
Kif28
Name: kinesin family member 28
Synonyms: LOC383592, Gm1305
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 383592
Homologene: 130945
Rbbp8nl
Name: RBBP8 N-terminal like
Synonyms: BC066135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271887
Homologene: 76811
Abcb1a
Name: ATP-binding cassette, sub-family B member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Ankrd53
Name: ankyrin repeat domain 53
Synonyms: 4930564N15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75305
Homologene: 49810
Srl
Name: sarcalumenin
Synonyms: sar, 9830004M20Rik, sarcalumenin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106393
Homologene: 45500
Arrdc1
Name: arrestin domain containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215705
Homologene: 34835
Snx21
Name: sorting nexin family member 21
Synonyms: 5730407K14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 101113
Homologene: 43132
6030458C11Rik
Name: RIKEN cDNA 6030458C11 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77877
VEGA: 15
Homologene: 10149
Or4f56
Name: olfactory receptor family 4 subfamily F member 56
Synonyms: GA_x6K02T2Q125-72930843-72929905, MOR245-8, Olfr1305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258396
Homologene: 74056
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,937,132 bp
  • A to G, chromosome 1 at 126,023,194 bp
  • A to G, chromosome 1 at 179,735,994 bp
  • G to C, chromosome 2 at 24,188,621 bp
  • A to G, chromosome 2 at 24,925,665 bp
  • A to T, chromosome 2 at 111,872,961 bp
  • G to T, chromosome 2 at 120,697,436 bp
  • A to G, chromosome 2 at 164,791,902 bp
  • A to G, chromosome 2 at 180,279,226 bp
  • T to A, chromosome 3 at 65,531,642 bp
  • GGAGAG to GGAG, chromosome 3 at 88,112,771 bp
  • G to T, chromosome 3 at 88,762,155 bp
  • T to A, chromosome 3 at 132,909,910 bp
  • A to T, chromosome 4 at 117,904,911 bp
  • A to T, chromosome 4 at 141,328,468 bp
  • T to C, chromosome 5 at 8,701,628 bp
  • A to T, chromosome 5 at 36,604,657 bp
  • T to C, chromosome 5 at 41,703,534 bp
  • T to A, chromosome 5 at 87,242,429 bp
  • T to C, chromosome 5 at 115,588,110 bp
  • G to A, chromosome 5 at 118,228,818 bp
  • A to G, chromosome 5 at 137,298,673 bp
  • A to T, chromosome 6 at 29,445,749 bp
  • A to T, chromosome 6 at 65,456,336 bp
  • T to C, chromosome 6 at 83,768,173 bp
  • G to T, chromosome 6 at 127,073,216 bp
  • A to C, chromosome 7 at 43,355,200 bp
  • C to A, chromosome 7 at 45,518,614 bp
  • T to C, chromosome 7 at 58,797,352 bp
  • A to G, chromosome 7 at 75,866,342 bp
  • CG to CGACGGCGGAG, chromosome 7 at 97,579,908 bp
  • C to T, chromosome 7 at 121,649,640 bp
  • C to T, chromosome 7 at 141,809,744 bp
  • T to C, chromosome 8 at 22,665,893 bp
  • G to A, chromosome 8 at 22,932,361 bp
  • C to A, chromosome 8 at 71,714,425 bp
  • C to A, chromosome 8 at 71,889,007 bp
  • A to G, chromosome 9 at 19,643,665 bp
  • A to G, chromosome 9 at 114,615,107 bp
  • A to G, chromosome 9 at 119,486,644 bp
  • T to C, chromosome 10 at 120,784,106 bp
  • A to G, chromosome 11 at 6,340,477 bp
  • T to A, chromosome 11 at 46,112,875 bp
  • T to A, chromosome 11 at 74,661,918 bp
  • A to T, chromosome 11 at 98,770,836 bp
  • T to A, chromosome 11 at 102,202,276 bp
  • A to G, chromosome 11 at 116,471,438 bp
  • A to G, chromosome 12 at 76,035,630 bp
  • T to C, chromosome 14 at 101,634,350 bp
  • T to C, chromosome 15 at 12,812,068 bp
  • T to C, chromosome 15 at 25,805,659 bp
  • A to G, chromosome 15 at 79,085,560 bp
  • A to T, chromosome 15 at 84,787,446 bp
  • C to T, chromosome 15 at 101,997,908 bp
  • T to C, chromosome 16 at 4,482,831 bp
  • C to T, chromosome 17 at 12,667,305 bp
  • G to A, chromosome 17 at 44,814,192 bp
  • G to T, chromosome 17 at 46,672,371 bp
  • T to C, chromosome 17 at 71,353,506 bp
  • G to T, chromosome 19 at 5,343,963 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6875 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044971-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.