Strain Name:
C57BL/6J-MtgxR6938Btlr/Mmmh
Stock Number:
045052-MU
Citation ID:
RRID:MMRRC_045052-MU
Other Names:
R6938 (G1)
Major Collection:

Strain Information

Angpt2
Name: angiopoietin 2
Synonyms: Ang2, Ang-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
Col18a1
Name: collagen, type XVIII, alpha 1
Synonyms: endostatin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12822
HGNC: HGNC:2195
Homologene: 7673
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: Bach, AU014716, 2410041A17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 3110031G15Rik, GMAP-210, 6030460N08Rik, TRIP230, 2610511G22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, 5730481H23Rik, mei2-5, AKAP450, repro12
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Xpo7
Name: exportin 7
Synonyms: Ranbp16, 4930506C02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: 2810429C13Rik, 1110031N14Rik, D430026L04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Gstz1
Name: glutathione transferase zeta 1 (maleylacetoacetate isomerase)
Synonyms: maleylacetoacetate isomerase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14874
VEGA: 12
HGNC: HGNC:4643
Homologene: 7747
Casr
Name: calcium-sensing receptor
Synonyms: CaR, cation sensing receptor, Gprc2a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: C330002D13Rik, Coh1, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Plk2
Name: polo like kinase 2
Synonyms: Snk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20620
VEGA: 13
Homologene: 21317
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Acp6
Name: acid phosphatase 6, lysophosphatidic
Synonyms: 5730559A09Rik, mPACPL1, ACPL1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66659
Homologene: 41128
Timm8b
Name: translocase of inner mitochondrial membrane 8B
Synonyms: Tim8b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30057
VEGA: 9
Homologene: 8262
Kctd10
Name: potassium channel tetramerisation domain containing 10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330171
Homologene: 32652
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213773
Homologene: 4711
Tmem231
Name: transmembrane protein 231
Synonyms: 4932417I16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234740
Homologene: 78035
Btg3
Name: BTG anti-proliferation factor 3
Synonyms: ANA, tob5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12228
HGNC: HGNC:1132
Homologene: 4953
Sp9
Name: trans-acting transcription factor 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381373
Homologene: 66935
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Mmrn2
Name: multimerin 2
Synonyms: Emilin3, EndoGlyx-1, ENDOGLYX1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Enpep
Name: glutamyl aminopeptidase
Synonyms: 6030431M22Rik, Bp-1/6C3, Ly51, aminopeptidase-A, Ly-51, APA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Ccl1
Name: C-C motif chemokine ligand 1
Synonyms: CCR8 ligand, I-309, Scya1, Tca-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20290
Homologene: 55541
Drc3
Name: dynein regulatory complex subunit 3
Synonyms: m6Bei, 4930449E07Rik, Lrrc48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74665
Homologene: 12581
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Or13e8
Name: olfactory receptor family 13 subfamily E member 8
Synonyms: GA_x6K02T2N78B-16239704-16240654, mOR6, Olfr70, MOR262-10
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56014
Homologene: 10459
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: 2900022I03Rik, MDC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mag-2, Mpa2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt2, Astt-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Mex3d
Name: mex3 RNA binding family member D
Synonyms: Rkhd1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237400
Homologene: 16890
Vmn1r19
Name: vomeronasal 1 receptor 19
Synonyms: V1rc27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171200
Homologene: 134034
Txk
Name: TXK tyrosine kinase
Synonyms: A130089B16Rik, PTK4, Btkl, Rlk
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22165
Homologene: 2497
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66857
Homologene: 11745
Klk1b26
Name: kallikrein 1-related petidase b26
Synonyms: EGF-BP type B, mGK-26, Egfbp2, Klk26, PRECE-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16618
Homologene: 68141
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Kyat3
Name: kynurenine aminotransferase 3
Synonyms: Ccbl2, Kat3, KATIII
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229905
Homologene: 2994
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 2 at 73,273,272 bp
  • G to T, chromosome 2 at 125,750,352 bp
  • A to C, chromosome 2 at 130,775,753 bp
  • T to C, chromosome 3 at 52,103,738 bp
  • T to C, chromosome 3 at 97,175,633 bp
  • T to C, chromosome 3 at 129,298,950 bp
  • T to A, chromosome 3 at 142,725,422 bp
  • C to T, chromosome 4 at 43,696,286 bp
  • T to C, chromosome 4 at 152,217,894 bp
  • C to A, chromosome 5 at 4,046,628 bp
  • A to T, chromosome 5 at 8,146,499 bp
  • C to A, chromosome 5 at 72,699,149 bp
  • T to C, chromosome 5 at 105,135,077 bp
  • C to A, chromosome 5 at 114,370,130 bp
  • T to C, chromosome 5 at 137,605,616 bp
  • T to C, chromosome 6 at 57,405,007 bp
  • T to C, chromosome 6 at 136,616,987 bp
  • A to T, chromosome 7 at 44,016,294 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • G to T, chromosome 8 at 18,698,089 bp
  • T to C, chromosome 8 at 105,353,432 bp
  • T to C, chromosome 8 at 111,933,512 bp
  • A to G, chromosome 9 at 50,604,994 bp
  • T to A, chromosome 9 at 103,328,554 bp
  • T to A, chromosome 10 at 39,862,710 bp
  • T to C, chromosome 10 at 43,997,383 bp
  • T to A, chromosome 10 at 77,112,499 bp
  • T to C, chromosome 10 at 80,382,240 bp
  • A to T, chromosome 11 at 60,394,123 bp
  • G to A, chromosome 11 at 71,218,216 bp
  • A to T, chromosome 11 at 82,176,858 bp
  • G to C, chromosome 12 at 3,476,149 bp
  • A to G, chromosome 12 at 87,147,169 bp
  • A to T, chromosome 12 at 101,837,627 bp
  • T to A, chromosome 13 at 110,396,680 bp
  • A to T, chromosome 14 at 34,398,714 bp
  • T to C, chromosome 14 at 70,666,024 bp
  • T to G, chromosome 15 at 35,423,198 bp
  • T to C, chromosome 16 at 36,495,921 bp
  • T to C, chromosome 16 at 78,360,328 bp
  • A to T, chromosome 17 at 24,705,213 bp
  • G to A, chromosome 17 at 28,961,581 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6938 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045052-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.