Strain Name:
C57BL/6J-MtgxR6969Btlr/Mmmh
Stock Number:
045079-MU
Citation ID:
RRID:MMRRC_045079-MU
Other Names:
R6969 (G1)
Major Collection:

Strain Information

Kif3c
Name: kinesin family member 3C
Synonyms: N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16570
VEGA: 12
HGNC: HGNC:6321
Homologene: 55640
Fasl
Name: Fas ligand
Synonyms: CD178, Tnfsf6, Fas-L, CD95L, APT1LG1, Fasl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14103
Homologene: 533
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Shmt1
Name: serine hydroxymethyltransferase 1 (soluble)
Synonyms: mshmt2, Shmt, mshmt, mshmt1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20425
Homologene: 3074
Smarcc1
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Synonyms: msp3, SRG3, BAF155
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20588
Homologene: 68296
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: Listerin, Rnf160, Zfp294, 4930528H02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Rab3gap2
Name: RAB3 GTPase activating protein subunit 2
Synonyms: 1110059F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98732
Homologene: 40842
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233900
Homologene: 8856
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 9030205D12Rik, 1810014J18Rik, AD013, A330063D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109151
Homologene: 11844
Exoc2
Name: exocyst complex component 2
Synonyms: Gm29675, 2410030I24Rik, Sec5l1, Sec5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
Sec24a
Name: SEC24 homolog A, COPII coat complex component
Synonyms: 9430090N21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77371
Homologene: 70131
Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms: D730028O18Rik, D130059B05Rik, BIG1, ARFGEP1, P200
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211673
Homologene: 4687
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TAF3B1, Tfnr, TFC5, TFIIIB90, TFIIIB150, B130055N23Rik, G630013P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544971
Homologene: 34582
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C130057E09Rik, C030046E11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226089
Homologene: 13806
Dnttip2
Name: deoxynucleotidyltransferase, terminal, interacting protein 2
Synonyms: 4930588M11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99480
Homologene: 124162
Gpsm1
Name: G-protein signalling modulator 1 (AGS3-like, C. elegans)
Synonyms: Ags3, 1810037C22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67839
Homologene: 16987
Slc39a14
Name: solute carrier family 39 (zinc transporter), member 14
Synonyms: G630015O18Rik, Zip14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213053
Homologene: 15037
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Lpin1
Name: lipin 1
Synonyms: Lipin1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14245
VEGA: 12
Homologene: 9266
Sptb
Name: spectrin beta, erythrocytic
Synonyms: LOC383567, brain erythroid spectrin (235E), spectrin R, D330027P03Rik, Spnb-1, Spnb1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20741
Homologene: 295
Zfp59
Name: zinc finger protein 59
Synonyms: Mfg-2, Mfg2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22717
Homologene: 137243
Aak1
Name: AP2 associated kinase 1
Synonyms: 5530400K14Rik, D6Ertd245e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Erc2
Name: ELKS/RAB6-interacting/CAST family member 2
Synonyms: ELKS2alpha, D14Ertd171e, CAST
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 238988
Homologene: 69188
Sbsn
Name: suprabasin
Synonyms: 1110005D19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 282619
Homologene: 17900
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Slc5a2
Name: solute carrier family 5 (sodium/glucose cotransporter), member 2
Synonyms: Sglt2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246787
Homologene: 2289
Tgm3
Name: transglutaminase 3, E polypeptide
Synonyms: we, TG E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21818
Homologene: 20690
Unc13b
Name: unc-13 homolog B
Synonyms: Munc13-2, Unc13h2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 22249
Homologene: 31376
Patl2
Name: protein associated with topoisomerase II homolog 2 (yeast)
Synonyms: 4930424G05Rik, Pat1a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67578
Homologene: 12155
Fat3
Name: FAT atypical cadherin 3
Synonyms: D430038H04Rik, LOC382129, 9430076A06Rik, LOC234973
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Scaf1
Name: SR-related CTD-associated factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233208
Efr3b
Name: EFR3 homolog B
Synonyms: C030014M07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668212
VEGA: 12
Homologene: 66195
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: MHC2A, Myhs-f1, Myhs-f, Myhsf1, MyHC-IIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Mmd
Name: monocyte to macrophage differentiation-associated
Synonyms: 1200017E07Rik, 1810073C06Rik, Paqr11
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67468
HGNC: HGNC:7153
Homologene: 8204
Ripor3
Name: RIPOR family member 3
Synonyms: 2310033K02Rik, Fam65c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69553
Homologene: 15438
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Zfp641
Name: zinc finger protein 641
Synonyms: 9930016F01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239652
VEGA: 15
Homologene: 17548
Lrrc19
Name: leucine rich repeat containing 19
Synonyms: 9130022A01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100061
Homologene: 36410
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Pkn1
Name: protein kinase N1
Synonyms: PAK1, Pkn, Prkcl1, F730027O18Rik, Stk3, PRK1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: 2700007F12Rik, A530052M23Rik, [a]1 (XVI) collagen
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Vgf
Name: VGF nerve growth factor inducible
Synonyms: LOC381677
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381677
Homologene: 2536
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Myom3
Name: myomesin family, member 3
Synonyms: 8430427K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242702
Homologene: 19432
Kcnh8
Name: potassium voltage-gated channel, subfamily H (eag-related), member 8
Synonyms: C130090D05Rik, ELK1, Kv12.1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 211468
Homologene: 14332
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64379
Homologene: 41481
Dusp10
Name: dual specificity phosphatase 10
Synonyms: 2610306G15Rik, MKP-5, MKP5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 63953
HGNC: HGNC:3065
Homologene: 5215
Gtpbp10
Name: GTP-binding protein 10 (putative)
Synonyms: 4930545J22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207704
Homologene: 8114
Or5bw2
Name: olfactory receptor family 5 subfamily BW member 2
Synonyms: Olfr1350, MOR222-3, GA_x6K02T2QGBW-3300391-3301317
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258384
Or7g35
Name: olfactory receptor family 7 subfamily G member 35
Synonyms: Olfr855, MOR148-1, GA_x6K02T2PVTD-13330461-13331399
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258517
HGNC: HGNC:8466
Homologene: 74176
B4galnt2
Name: beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms: Dlb1, Dlb-1, Galgt2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14422
Homologene: 7329
Insm2
Name: insulinoma-associated 2
Synonyms: mlt 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56856
VEGA: 12
Homologene: 10651
Tymp
Name: thymidine phosphorylase
Synonyms: gliostatin, 2900072D10Rik, PD-ECGF, PDECGF, Ecgf1, Pdgfec
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Or56a41
Name: olfactory receptor family 56 subfamily A member 41, pseudogene 1
Synonyms: MOR40-10P, GA_x6K02T2PBJ9-7720330-7719479, Olfr680
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257981
Stx17
Name: syntaxin 17
Synonyms: 9030425C21Rik, 6330411F21Rik, 4833418L03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67727
Homologene: 9917
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: OATP-E, Slc21a12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108115
Homologene: 9482
Sppl2b
Name: signal peptide peptidase like 2B
Synonyms: 3110056O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73218
VEGA: 10
Homologene: 10605
Ceacam16
Name: CEA cell adhesion molecule 16
Synonyms: LOC330483
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330483
Homologene: 19857
Tti2
Name: TELO2 interacting protein 2
Synonyms: BC019943
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234138
Homologene: 11836
Larp7-ps
Name: La ribonucleoprotein 7, transcriptional regulator, pseudogene
Synonyms: Gm12666
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68280
Or13l2
Name: olfactory receptor family 13 subfamily L member 2
Synonyms: MOR217-1, Olfr1402, GA_x6K02T2R76Y-3201307-3200360
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 258272
VEGA: 3
Homologene: 17165
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,153,678 bp
  • G to T, chromosome 1 at 10,153,679 bp
  • C to A, chromosome 1 at 46,358,238 bp
  • G to T, chromosome 1 at 161,781,675 bp
  • T to C, chromosome 1 at 184,068,888 bp
  • T to C, chromosome 1 at 185,236,012 bp
  • C to T, chromosome 2 at 26,340,543 bp
  • A to T, chromosome 2 at 122,128,929 bp
  • A to G, chromosome 2 at 130,042,029 bp
  • T to C, chromosome 2 at 167,985,737 bp
  • G to A, chromosome 2 at 180,464,808 bp
  • A to T, chromosome 3 at 86,619,590 bp
  • A to T, chromosome 3 at 97,410,802 bp
  • A to G, chromosome 3 at 122,282,492 bp
  • G to A, chromosome 3 at 158,156,913 bp
  • T to C, chromosome 4 at 43,263,538 bp
  • A to T, chromosome 4 at 48,140,462 bp
  • A to G, chromosome 4 at 92,191,589 bp
  • G to T, chromosome 4 at 94,639,373 bp
  • T to C, chromosome 4 at 123,457,800 bp
  • A to T, chromosome 4 at 130,093,087 bp
  • T to C, chromosome 4 at 135,801,060 bp
  • C to A, chromosome 5 at 5,555,331 bp
  • T to G, chromosome 5 at 32,983,860 bp
  • G to T, chromosome 5 at 137,031,653 bp
  • T to A, chromosome 6 at 86,981,335 bp
  • G to A, chromosome 7 at 6,570,321 bp
  • A to G, chromosome 7 at 19,852,305 bp
  • A to T, chromosome 7 at 24,275,381 bp
  • T to C, chromosome 7 at 27,853,497 bp
  • A to G, chromosome 7 at 30,753,191 bp
  • C to A, chromosome 7 at 45,007,829 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • T to C, chromosome 7 at 105,091,256 bp
  • A to G, chromosome 7 at 127,596,323 bp
  • A to G, chromosome 7 at 128,272,077 bp
  • A to T, chromosome 8 at 17,216,789 bp
  • A to G, chromosome 8 at 31,154,301 bp
  • A to G, chromosome 8 at 83,241,542 bp
  • T to C, chromosome 8 at 83,683,426 bp
  • A to C, chromosome 8 at 90,978,914 bp
  • A to G, chromosome 8 at 92,677,330 bp
  • G to A, chromosome 9 at 16,029,916 bp
  • A to T, chromosome 9 at 19,584,590 bp
  • C to G, chromosome 9 at 110,196,320 bp
  • G to A, chromosome 10 at 80,865,125 bp
  • G to A, chromosome 10 at 127,326,643 bp
  • T to C, chromosome 11 at 51,700,816 bp
  • C to T, chromosome 11 at 60,804,327 bp
  • T to C, chromosome 11 at 67,197,266 bp
  • T to A, chromosome 11 at 83,389,726 bp
  • G to C, chromosome 11 at 90,257,536 bp
  • A to T, chromosome 11 at 95,891,930 bp
  • G to A, chromosome 12 at 3,366,114 bp
  • A to G, chromosome 12 at 3,968,624 bp
  • A to G, chromosome 12 at 16,580,861 bp
  • T to C, chromosome 12 at 55,600,178 bp
  • A to T, chromosome 12 at 76,608,007 bp
  • A to G, chromosome 12 at 86,882,694 bp
  • A to G, chromosome 13 at 30,911,178 bp
  • A to T, chromosome 13 at 100,074,531 bp
  • A to T, chromosome 14 at 27,898,596 bp
  • C to A, chromosome 14 at 70,308,826 bp
  • G to A, chromosome 15 at 89,374,048 bp
  • A to T, chromosome 15 at 98,290,567 bp
  • A to T, chromosome 16 at 87,415,690 bp
  • C to T, chromosome 17 at 52,877,943 bp
  • A to G, chromosome 17 at 66,912,418 bp
  • A to T, chromosome 19 at 29,585,782 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6969 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045079-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.