Strain Name:
C57BL/6J-MtgxR6984Btlr/Mmmh
Stock Number:
045091-MU
Citation ID:
RRID:MMRRC_045091-MU
Other Names:
R6984 (G1)
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Naa15
Name: N(alpha)-acetyltransferase 15, NatA auxiliary subunit
Synonyms: ASTBDN, tubedown, Tbdn-1, mNAT1, 5730450D16Rik, Narg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74838
Homologene: 14211
Tcf12
Name: transcription factor 12
Synonyms: bHLHb20, HEB, HTF4, ALF1, ME1, HEBAlt, HTF-4, REB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21406
Homologene: 40774
Fip1l1
Name: factor interacting with PAPOLA and CPSF1
Synonyms: Rje, 1300019H17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66899
Homologene: 136254
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Ticam1
Name: TIR domain containing adaptor molecule 1
Synonyms: Trif, TICAM-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106759
Homologene: 8605
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810040A01Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Rhot1
Name: ras homolog family member T1
Synonyms: C430039G08Rik, Arht1, 2210403N23Rik, Miro1, FLJ11040
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 59040
Homologene: 56803
Aktip
Name: AKT interacting protein
Synonyms: Ft1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14339
Homologene: 7721
Lgr6
Name: leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms: A530037C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329252
Homologene: 49680
Map2
Name: microtubule-associated protein 2
Synonyms: G1-397-34, Mtap2, repro4, MAP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Pi4kb
Name: phosphatidylinositol 4-kinase beta
Synonyms: ESTM41, Pik4cb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 107650
HGNC: HGNC:8984
Homologene: 6741
Sympk
Name: symplekin
Synonyms: 1500016F02Rik, 4632415H16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68188
Homologene: 37969
Mpp7
Name: membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
Synonyms: 2810038M04Rik, 1110068J02Rik, LOC381166, 5430426E14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75739
VEGA: 18
Homologene: 1455
Smox
Name: spermine oxidase
Synonyms: SMO, B130066H01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228608
Homologene: 69268
Zfp268
Name: zinc finger protein 268
Synonyms: Gm13212
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433801
Homologene: 133076
Fhdc1
Name: FH2 domain containing 1
Synonyms: 6330505N24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229474
Homologene: 18920
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Rnase9
Name: ribonuclease, RNase A family, 9 (non-active)
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328401
VEGA: 14
Homologene: 18830
Rpgrip1l
Name: Rpgrip1-like
Synonyms: fantom, Ftm, Nphp8, 1700047E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244585
Homologene: 18296
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268933
Homologene: 6870
Plpp4
Name: phospholipid phosphatase 4
Synonyms: C030048B12Rik, Ppapdc1a, LOC381925
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381925
Homologene: 38751
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Psd3
Name: pleckstrin and Sec7 domain containing 3
Synonyms: 4931420C21Rik, EFA6D
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234353
Homologene: 87257
Abcb5
Name: ATP-binding cassette, sub-family B member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Ttc19
Name: tetratricopeptide repeat domain 19
Synonyms: 2810460C24Rik, 2010204O13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72795
Homologene: 9831
Dhx30
Name: DExH-box helicase 30
Synonyms: 2810477H02Rik, C130058C04Rik, helG, DEAH (Asp-Glu-Ala-His) box polypeptide 30, Ddx30
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72831
Homologene: 15779
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Or1e30
Name: olfactory receptor family 1 subfamily E member 30
Synonyms: MOR135-26, GA_x6K02T2P1NL-3938806-3939741, Olfr390
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258344
Homologene: 115483
Csf2rb
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
Synonyms: AIC2B, Il3rb1, beta c, Bc, CDw131, Csf2rb1, Il3r, common beta chain, Il5rb
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12983
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Prrt4
Name: proline-rich transmembrane protein 4
Synonyms: D330027H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101359
Homologene: 46116
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4, NGL-3, Ngl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272381
Homologene: 45681
Enthd1
Name: ENTH domain containing 1
Synonyms: LOC383075
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 383075
VEGA: 15
Homologene: 45131
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Plxnc1
Name: plexin C1
Synonyms: vespr, CD232, 2510048K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
3425401B19Rik
Name: RIKEN cDNA 3425401B19 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504518
VEGA: 14
Homologene: 54908
Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
Synonyms: Jip1, mjip-2a, Skip, Prkm8ip, IB1, JIP-1, MAPK8IP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19099
HGNC: HGNC:6882
Homologene: 31314
Cpb2
Name: carboxypeptidase B2
Synonyms: carboxypeptidase R, CPR, TAFI, carboxypeptidase U, CPU, thrombin-activatable fibrinolysis inhibitor, 1110032P04Rik, 4930405E17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56373
VEGA: 14
HGNC: HGNC:2300
Homologene: 55610
Megf11
Name: multiple EGF-like-domains 11
Synonyms: 2410080H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214058
Homologene: 13031
Pgm1
Name: phosphoglucomutase 1
Synonyms: Pgm-2, Pgm1a, 2610020G18Rik, Pgm2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72157
HGNC: HGNC:8905
Homologene: 1979
Vmn2r17
Name: vomeronasal 2, receptor 17
Synonyms: EG384221
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384221
Homologene: 104825
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: Melk2, ether a go-go like, C030044P22Rik, Elk2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Hsd3b7
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101502
Homologene: 41617
Or10v5
Name: olfactory receptor family 10 subfamily V member 5
Synonyms: GA_x6K02T2RE5P-2172809-2171862, Olfr1417, MOR266-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258938
Homologene: 27304
Ctsw
Name: cathepsin W
Synonyms: lymphopain
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13041
VEGA: 19
HGNC: HGNC:2546
Homologene: 37471
Med24
Name: mediator complex subunit 24
Synonyms: D11Ertd307e, 100kDa, Trap100, Pparb2, R75526, Gse2, Thrap4, DRIP100
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23989
Homologene: 40795
Apol11b
Name: apolipoprotein L 11b
Synonyms: A330102K04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328563
Homologene: 129975
Ighv10-1
Name: immunoglobulin heavy variable 10-1
Synonyms: Gm16696
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380808
HGNC: HGNC:5623
2900055J20Rik
Name: RIKEN cDNA 2900055J20 gene
Type: Gene
Species: Mouse
Chromosome: 18
Trgv6
Name: T cell receptor gamma, variable 6
Synonyms: Tcrg-V6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21640
Or10d5b
Name: olfactory receptor family 10 subfamily D member 5B, pseudogene 1
Synonyms: Olfr977, MOR224-11, GA_x6K02T2PVTD-33675353-33674411
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257903
VEGA: 9
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 66,415,236 bp
  • A to T, chromosome 1 at 71,626,079 bp
  • A to G, chromosome 1 at 134,988,002 bp
  • A to C, chromosome 2 at 40,822,628 bp
  • A to T, chromosome 2 at 92,386,727 bp
  • T to C, chromosome 2 at 112,875,091 bp
  • C to T, chromosome 2 at 131,522,111 bp
  • A to G, chromosome 3 at 51,472,600 bp
  • T to G, chromosome 3 at 84,444,516 bp
  • C to T, chromosome 3 at 94,996,934 bp
  • A to T, chromosome 4 at 99,929,654 bp
  • T to C, chromosome 4 at 145,620,616 bp
  • T to A, chromosome 5 at 74,542,073 bp
  • T to A, chromosome 5 at 109,452,667 bp
  • A to T, chromosome 6 at 24,566,337 bp
  • G to T, chromosome 6 at 29,171,430 bp
  • A to G, chromosome 7 at 19,038,043 bp
  • A to T, chromosome 7 at 44,461,298 bp
  • A to C, chromosome 7 at 73,484,411 bp
  • T to A, chromosome 7 at 127,801,545 bp
  • C to T, chromosome 7 at 129,390,892 bp
  • A to G, chromosome 8 at 67,818,045 bp
  • A to T, chromosome 8 at 91,126,718 bp
  • A to C, chromosome 8 at 91,260,798 bp
  • C to T, chromosome 9 at 39,974,734 bp
  • A to G, chromosome 9 at 64,686,452 bp
  • G to A, chromosome 9 at 72,006,759 bp
  • A to G, chromosome 9 at 110,091,417 bp
  • T to C, chromosome 10 at 26,282,855 bp
  • G to A, chromosome 10 at 94,831,530 bp
  • A to G, chromosome 11 at 62,314,037 bp
  • G to A, chromosome 11 at 73,787,777 bp
  • T to A, chromosome 11 at 80,233,484 bp
  • T to A, chromosome 11 at 87,868,598 bp
  • A to G, chromosome 11 at 98,718,542 bp
  • A to G, chromosome 12 at 114,196,730 bp
  • A to T, chromosome 12 at 114,479,082 bp
  • A to G, chromosome 12 at 118,927,277 bp
  • G to T, chromosome 13 at 19,190,644 bp
  • A to T, chromosome 13 at 21,982,021 bp
  • C to A, chromosome 13 at 75,761,887 bp
  • A to G, chromosome 14 at 32,661,980 bp
  • C to T, chromosome 14 at 51,039,216 bp
  • T to C, chromosome 14 at 75,265,458 bp
  • A to T, chromosome 15 at 63,825,049 bp
  • T to C, chromosome 15 at 76,175,327 bp
  • T to C, chromosome 15 at 77,635,346 bp
  • A to G, chromosome 15 at 78,345,519 bp
  • A to T, chromosome 15 at 80,560,108 bp
  • G to T, chromosome 15 at 99,228,552 bp
  • G to A, chromosome 16 at 49,110,412 bp
  • A to G, chromosome 17 at 25,828,235 bp
  • G to A, chromosome 17 at 30,739,738 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • G to A, chromosome 17 at 67,779,112 bp
  • C to T, chromosome 18 at 7,441,623 bp
  • G to A, chromosome 18 at 40,257,048 bp
  • C to A, chromosome 18 at 65,305,678 bp
  • C to T, chromosome 19 at 5,466,618 bp
  • T to A, chromosome 19 at 11,828,304 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6984 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045091-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.