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Strain Name:
C57BL/6J-MtgxR6989Btlr/Mmmh
Stock Number:
045095-MU
Citation ID:
RRID:MMRRC_045095-MU
Other Names:
R6989 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: 2900073D12Rik, VGLUT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140919
Homologene: 121617
Utp20
Name: UTP20 small subunit processome component
Synonyms: mDRIM, DRIM, 3830408P06Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70683
VEGA: 10
Homologene: 38373
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Fkbp5
Name: FK506 binding protein 5
Synonyms: FKBP51, Dit1, D17Ertd592e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14229
HGNC: HGNC:3721
Homologene: 3038
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 52,068,815 bp
  • T to C, chromosome 1 at 58,085,452 bp
  • T to A, chromosome 1 at 66,414,906 bp
  • C to T, chromosome 1 at 74,423,954 bp
  • T to G, chromosome 1 at 134,969,295 bp
  • A to G, chromosome 1 at 135,146,997 bp
  • C to A, chromosome 2 at 69,472,455 bp
  • A to G, chromosome 2 at 82,976,954 bp
  • G to A, chromosome 2 at 90,707,020 bp
  • A to G, chromosome 2 at 155,503,460 bp
  • A to T, chromosome 3 at 27,102,488 bp
  • T to C, chromosome 3 at 53,857,981 bp
  • G to T, chromosome 3 at 129,280,950 bp
  • T to A, chromosome 3 at 135,235,127 bp
  • A to T, chromosome 3 at 154,763,677 bp
  • T to A, chromosome 5 at 21,801,219 bp
  • A to G, chromosome 5 at 50,006,884 bp
  • A to T, chromosome 5 at 136,279,648 bp
  • C to A, chromosome 6 at 17,535,928 bp
  • T to A, chromosome 6 at 17,535,929 bp
  • T to A, chromosome 6 at 30,625,892 bp
  • A to T, chromosome 6 at 41,625,456 bp
  • G to T, chromosome 6 at 88,099,303 bp
  • G to A, chromosome 6 at 111,207,805 bp
  • A to T, chromosome 6 at 113,300,583 bp
  • T to A, chromosome 6 at 142,688,981 bp
  • T to A, chromosome 7 at 3,822,164 bp
  • T to A, chromosome 7 at 27,280,840 bp
  • T to A, chromosome 7 at 32,101,149 bp
  • T to C, chromosome 7 at 34,202,520 bp
  • T to C, chromosome 7 at 51,661,476 bp
  • T to G, chromosome 7 at 141,639,979 bp
  • G to A, chromosome 8 at 69,038,862 bp
  • T to C, chromosome 8 at 88,308,786 bp
  • A to G, chromosome 9 at 119,486,329 bp
  • T to G, chromosome 10 at 41,581,353 bp
  • A to G, chromosome 10 at 80,805,504 bp
  • T to C, chromosome 10 at 88,778,240 bp
  • A to T, chromosome 10 at 115,209,569 bp
  • T to C, chromosome 10 at 127,192,877 bp
  • C to T, chromosome 11 at 3,890,076 bp
  • T to C, chromosome 11 at 58,287,402 bp
  • A to G, chromosome 11 at 117,156,394 bp
  • T to A, chromosome 13 at 4,449,046 bp
  • T to C, chromosome 13 at 21,287,499 bp
  • T to C, chromosome 13 at 56,527,061 bp
  • C to T, chromosome 13 at 62,858,177 bp
  • A to G, chromosome 13 at 67,389,961 bp
  • C to A, chromosome 14 at 53,666,345 bp
  • A to G, chromosome 14 at 54,468,493 bp
  • G to A, chromosome 14 at 121,627,379 bp
  • G to A, chromosome 14 at 122,650,288 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • T to A, chromosome 15 at 35,448,581 bp
  • G to A, chromosome 16 at 3,995,838 bp
  • C to T, chromosome 17 at 28,415,945 bp
  • C to T, chromosome 17 at 56,269,900 bp
  • T to C, chromosome 17 at 67,753,758 bp
  • A to C, chromosome 17 at 71,897,952 bp
  • T to G, chromosome 17 at 74,630,989 bp
  • T to C, chromosome 17 at 83,831,674 bp
  • G to T, chromosome 18 at 39,099,629 bp
  • A to T, chromosome 18 at 82,628,363 bp
  • A to T, chromosome 19 at 4,921,167 bp
  • A to G, chromosome 19 at 7,456,491 bp
  • A to G, chromosome 19 at 43,832,172 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6989 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045095-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.