Strain Name:
C57BL/6J-MtgxR7041Btlr/Mmmh
Stock Number:
045140-MU
Citation ID:
RRID:MMRRC_045140-MU
Other Names:
R7041 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, D630035I23Rik, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Prgs, Gaps
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, 2810403B08Rik, Lrriq2, E130116N02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, Trs85, D030074E01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Ago1
Name: argonaute RISC catalytic subunit 1
Synonyms: argonaute 1, Eif2c1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 236511
HGNC: HGNC:3262
Homologene: 81826
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Ptprc
Name: protein tyrosine phosphatase receptor type C
Synonyms: CD45, T200, Ly-5, Lyt-4, B220
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Golga3
Name: golgin A3
Synonyms: 5430416E01Rik, G1-499-14, repro27, Mea-2, Mea2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Hspe1
Name: heat shock protein 1 (chaperonin 10)
Synonyms: mitochondrial chaperonin 10, Hsp10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15528
HGNC: HGNC:5269
Homologene: 20500
Zfp738
Name: zinc finger protein 738
Synonyms: 6720487G11Rik, 3830402I07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408068
Homologene: 133713
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, 6330500D04Rik, 1700108N18Rik, E430013J17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: EGF-TM7 receptor, 1110033N21Rik, Etl, Eltd1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Tmem167
Name: transmembrane protein 167
Synonyms: 0610041E09Rik, Gm10085, 5730424F14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66074
Homologene: 41626
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Ccl2
Name: C-C motif chemokine ligand 2
Synonyms: monocyte chemoattractant protein-1, Scya2, MCP1, HC11, SMC-CF, MCAF, monocyte chemotactic protein, Sigje, MCP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20296
Homologene: 2241
Camk1
Name: calcium/calmodulin-dependent protein kinase I
Synonyms: CaMKIalpha, Camk, D6Ertd263e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52163
HGNC: HGNC:1459
Homologene: 117458
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Xylt2
Name: xylosyltransferase II
Synonyms: E030002B02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217119
Homologene: 23349
Insrr
Name: insulin receptor-related receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23920
HGNC: HGNC:6093
Homologene: 56539
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Zfp429
Name: zinc finger protein 429
Synonyms: 2810487A22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72807
Homologene: 110878
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Spaca6
Name: sperm acrosome associated 6
Synonyms: Ncrna00085, 4930546H06Rik, B230206P06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75202
Homologene: 53443
Insr
Name: insulin receptor
Synonyms: 4932439J01Rik, IR, D630014A15Rik, IR-A, IR-B, CD220
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240753
Homologene: 135779
Cav1
Name: caveolin 1, caveolae protein
Synonyms: Cav-1, caveolin-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12389
HGNC: HGNC:1527
Homologene: 1330
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57782
Homologene: 23287
Prickle2
Name: prickle planar cell polarity protein 2
Synonyms: 6720451F06Rik, 6230400G14Rik, Pk2, mpk2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243548
Homologene: 17889
Lrrc66
Name: leucine rich repeat containing 66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231296
Homologene: 51944
Atxn1
Name: ataxin 1
Synonyms: 2900016G23Rik, Sca1, Atx1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20238
VEGA: 13
Homologene: 281
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Prdm9
Name: PR domain containing 9
Synonyms: Meisetz, Dsbc1, G1-419-29, Rcr1, repro7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213389
Homologene: 104139
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: BPFD#36, froggy, fg, enr
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Vmn2r11
Name: vomeronasal 2, receptor 11
Synonyms: EG384219
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384219
Homologene: 129606
Rimklb
Name: ribosomal modification protein rimK-like family member B
Synonyms: 4931417E21Rik, NAAGS, 4933426K21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108653
Homologene: 18968
Acan
Name: aggrecan
Synonyms: b2b183Clo, Agc1, Cspg1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Or5m10
Name: olfactory receptor family 5 subfamily M member 10
Synonyms: Olfr1023, GA_x6K02T2Q125-47363965-47364900, MOR196-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258580
Homologene: 128087
Or2a51
Name: olfactory receptor family 2 subfamily A member 51
Synonyms: MOR261-5, Olfr435, GA_x6K02T2P3E9-4356476-4355535
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258647
Homologene: 110586
Togaram1
Name: TOG array regulator of axonemal microtubules 1
Synonyms: A430041B07Rik, Fam179b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328108
VEGA: 12
Homologene: 15025
Gask1a
Name: golgi associated kinase 1A
Synonyms: C730027P07Rik, Fam198a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245050
VEGA: 9
Homologene: 18620
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Ccdc183
Name: coiled-coil domain containing 183
Synonyms: 4921530D09Rik, Cccd183
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77058
Homologene: 50023
Or6c66
Name: olfactory receptor family 6 subfamily C member 66
Synonyms: MOR108-1, GA_x6K02T2PULF-11304679-11303744, Olfr798
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258549
Homologene: 133881
Ubash3a
Name: ubiquitin associated and SH3 domain containing, A
Synonyms: Sts-2, 5830413C03Rik, TULA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328795
Homologene: 56833
Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Synonyms: 1300010A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 79235
HGNC: HGNC:6685
Homologene: 3483
Hint3
Name: histidine triad nucleotide binding protein 3
Synonyms: HINT4, 0610010I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66847
Homologene: 12046
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,089,217 bp
  • T to C, chromosome 1 at 66,503,593 bp
  • T to A, chromosome 1 at 133,272,460 bp
  • T to C, chromosome 1 at 138,126,309 bp
  • T to G, chromosome 2 at 25,613,670 bp
  • A to G, chromosome 2 at 59,852,880 bp
  • A to T, chromosome 2 at 85,887,621 bp
  • A to T, chromosome 2 at 128,628,656 bp
  • G to T, chromosome 3 at 82,903,448 bp
  • T to C, chromosome 3 at 87,815,244 bp
  • A to T, chromosome 3 at 151,439,322 bp
  • T to A, chromosome 4 at 126,463,706 bp
  • A to T, chromosome 5 at 73,608,556 bp
  • A to G, chromosome 5 at 109,054,950 bp
  • G to A, chromosome 5 at 110,208,584 bp
  • A to T, chromosome 5 at 143,173,471 bp
  • A to G, chromosome 6 at 17,339,144 bp
  • T to G, chromosome 6 at 35,224,535 bp
  • T to A, chromosome 6 at 43,201,903 bp
  • A to G, chromosome 6 at 92,376,305 bp
  • T to A, chromosome 6 at 113,339,514 bp
  • A to T, chromosome 6 at 122,459,217 bp
  • A to T, chromosome 7 at 12,629,824 bp
  • T to C, chromosome 7 at 27,749,026 bp
  • G to T, chromosome 7 at 79,098,348 bp
  • A to G, chromosome 7 at 141,070,680 bp
  • A to T, chromosome 8 at 3,258,418 bp
  • A to T, chromosome 8 at 40,754,084 bp
  • A to T, chromosome 8 at 73,116,464 bp
  • C to T, chromosome 9 at 62,752,256 bp
  • A to T, chromosome 9 at 121,965,401 bp
  • G to T, chromosome 10 at 30,610,384 bp
  • G to A, chromosome 10 at 67,220,609 bp
  • T to A, chromosome 10 at 129,625,734 bp
  • A to G, chromosome 11 at 60,506,006 bp
  • T to A, chromosome 11 at 82,035,663 bp
  • A to G, chromosome 11 at 94,667,582 bp
  • C to T, chromosome 12 at 65,020,386 bp
  • A to G, chromosome 13 at 24,693,766 bp
  • A to G, chromosome 13 at 45,566,835 bp
  • A to T, chromosome 13 at 67,390,711 bp
  • A to G, chromosome 13 at 67,670,301 bp
  • G to A, chromosome 13 at 90,098,414 bp
  • A to G, chromosome 13 at 98,784,826 bp
  • C to T, chromosome 14 at 31,336,685 bp
  • T to A, chromosome 16 at 55,905,754 bp
  • C to T, chromosome 16 at 91,643,143 bp
  • C to A, chromosome 17 at 15,544,995 bp
  • C to T, chromosome 17 at 17,836,096 bp
  • T to C, chromosome 17 at 25,394,003 bp
  • A to G, chromosome 17 at 31,228,210 bp
  • T to A, chromosome 17 at 56,396,592 bp
  • A to T, chromosome 18 at 20,266,144 bp
  • T to C, chromosome 18 at 20,874,672 bp
  • G to C, chromosome 19 at 40,376,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045140-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.