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Strain Name:
C57BL/6J-MtgxR7041Btlr/Mmmh
Stock Number:
045140-MU
Citation ID:
RRID:MMRRC_045140-MU
Other Names:
R7041 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Gart
Name: phosphoribosylglycinamide formyltransferase
Synonyms: Gaps, Prgs
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14450
HGNC: HGNC:4163
Homologene: 637
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Cep97
Name: centrosomal protein 97
Synonyms: 4932439K18Rik, E130116N02Rik, 2810403B08Rik, Lrriq2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74201
Homologene: 11579
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, D030074E01Rik, Trs85
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 55,089,217 bp
  • T to C, chromosome 1 at 66,503,593 bp
  • T to A, chromosome 1 at 133,272,460 bp
  • T to C, chromosome 1 at 138,126,309 bp
  • T to G, chromosome 2 at 25,613,670 bp
  • A to G, chromosome 2 at 59,852,880 bp
  • A to T, chromosome 2 at 85,887,621 bp
  • A to T, chromosome 2 at 128,628,656 bp
  • G to T, chromosome 3 at 82,903,448 bp
  • T to C, chromosome 3 at 87,815,244 bp
  • A to T, chromosome 3 at 151,439,322 bp
  • T to A, chromosome 4 at 126,463,706 bp
  • A to T, chromosome 5 at 73,608,556 bp
  • A to G, chromosome 5 at 109,054,950 bp
  • G to A, chromosome 5 at 110,208,584 bp
  • A to T, chromosome 5 at 143,173,471 bp
  • A to G, chromosome 6 at 17,339,144 bp
  • T to G, chromosome 6 at 35,224,535 bp
  • T to A, chromosome 6 at 43,201,903 bp
  • A to G, chromosome 6 at 92,376,305 bp
  • T to A, chromosome 6 at 113,339,514 bp
  • A to T, chromosome 6 at 122,459,217 bp
  • A to T, chromosome 7 at 12,629,824 bp
  • T to C, chromosome 7 at 27,749,026 bp
  • G to T, chromosome 7 at 79,098,348 bp
  • A to G, chromosome 7 at 141,070,680 bp
  • A to T, chromosome 8 at 3,258,418 bp
  • A to T, chromosome 8 at 40,754,084 bp
  • A to T, chromosome 8 at 73,116,464 bp
  • C to T, chromosome 9 at 62,752,256 bp
  • A to T, chromosome 9 at 121,965,401 bp
  • G to T, chromosome 10 at 30,610,384 bp
  • G to A, chromosome 10 at 67,220,609 bp
  • T to A, chromosome 10 at 129,625,734 bp
  • A to G, chromosome 11 at 60,506,006 bp
  • T to A, chromosome 11 at 82,035,663 bp
  • A to G, chromosome 11 at 94,667,582 bp
  • C to T, chromosome 12 at 65,020,386 bp
  • A to G, chromosome 13 at 24,693,766 bp
  • A to G, chromosome 13 at 45,566,835 bp
  • A to T, chromosome 13 at 67,390,711 bp
  • A to G, chromosome 13 at 67,670,301 bp
  • G to A, chromosome 13 at 90,098,414 bp
  • A to G, chromosome 13 at 98,784,826 bp
  • C to T, chromosome 14 at 31,336,685 bp
  • T to A, chromosome 16 at 55,905,754 bp
  • C to T, chromosome 16 at 91,643,143 bp
  • C to A, chromosome 17 at 15,544,995 bp
  • C to T, chromosome 17 at 17,836,096 bp
  • T to C, chromosome 17 at 25,394,003 bp
  • A to G, chromosome 17 at 31,228,210 bp
  • T to A, chromosome 17 at 56,396,592 bp
  • A to T, chromosome 18 at 20,266,144 bp
  • T to C, chromosome 18 at 20,874,672 bp
  • G to C, chromosome 19 at 40,376,800 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7041 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045140-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.