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Strain Name:
C57BL/6J-MtgxR7062Btlr/Mmmh
Stock Number:
045158-MU
Citation ID:
RRID:MMRRC_045158-MU
Other Names:
R7062 (G1)
Major Collection:

Strain Information

Matr3
Name: matrin 3
Synonyms: D030046F20Rik, 2810017I02Rik, 1110061A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151
Tbx21
Name: T-box 21
Synonyms: Tblym, TBT1, T-bet, Tbet
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57765
Homologene: 8353
Adcy10
Name: adenylate cyclase 10
Synonyms: soluble adenylyl cyclase, sAC, 4930431D04Rik, Sacy
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271639
Homologene: 10188
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 25,826,085 bp
  • T to C, chromosome 1 at 45,417,625 bp
  • A to T, chromosome 1 at 59,119,612 bp
  • G to A, chromosome 1 at 83,117,814 bp
  • A to G, chromosome 1 at 132,601,969 bp
  • A to G, chromosome 1 at 158,688,511 bp
  • A to T, chromosome 1 at 160,226,650 bp
  • T to A, chromosome 1 at 162,134,491 bp
  • A to G, chromosome 1 at 165,538,522 bp
  • A to T, chromosome 1 at 173,332,115 bp
  • A to G, chromosome 1 at 181,112,334 bp
  • A to T, chromosome 2 at 69,704,322 bp
  • G to A, chromosome 2 at 70,217,157 bp
  • T to C, chromosome 2 at 87,950,224 bp
  • C to T, chromosome 2 at 104,951,878 bp
  • A to G, chromosome 2 at 127,577,120 bp
  • T to A, chromosome 2 at 132,091,269 bp
  • C to T, chromosome 3 at 84,174,891 bp
  • T to A, chromosome 3 at 108,402,510 bp
  • A to G, chromosome 4 at 48,140,442 bp
  • A to G, chromosome 4 at 106,683,980 bp
  • A to G, chromosome 4 at 141,766,690 bp
  • A to G, chromosome 4 at 155,626,811 bp
  • C to T, chromosome 5 at 31,192,831 bp
  • T to A, chromosome 5 at 73,659,293 bp
  • C to A, chromosome 5 at 92,192,740 bp
  • G to T, chromosome 5 at 96,213,791 bp
  • T to C, chromosome 5 at 113,745,602 bp
  • T to A, chromosome 5 at 114,911,091 bp
  • C to A, chromosome 5 at 120,861,465 bp
  • G to A, chromosome 5 at 140,785,485 bp
  • A to T, chromosome 5 at 144,893,546 bp
  • C to T, chromosome 6 at 30,502,017 bp
  • C to T, chromosome 6 at 30,640,677 bp
  • A to T, chromosome 6 at 113,522,796 bp
  • T to A, chromosome 6 at 116,219,988 bp
  • T to A, chromosome 6 at 142,599,146 bp
  • A to G, chromosome 7 at 18,482,596 bp
  • T to C, chromosome 7 at 29,150,194 bp
  • T to C, chromosome 7 at 45,817,890 bp
  • T to C, chromosome 7 at 103,329,086 bp
  • C to T, chromosome 7 at 108,395,830 bp
  • A to T, chromosome 7 at 128,270,040 bp
  • T to C, chromosome 7 at 144,552,473 bp
  • A to G, chromosome 8 at 3,607,834 bp
  • G to A, chromosome 8 at 44,950,216 bp
  • T to C, chromosome 8 at 71,663,237 bp
  • T to C, chromosome 8 at 85,302,908 bp
  • T to C, chromosome 8 at 105,722,876 bp
  • A to T, chromosome 9 at 39,470,057 bp
  • T to C, chromosome 9 at 44,696,135 bp
  • C to T, chromosome 9 at 65,885,010 bp
  • G to A, chromosome 9 at 119,037,470 bp
  • T to C, chromosome 10 at 80,895,049 bp
  • G to T, chromosome 10 at 120,208,826 bp
  • T to A, chromosome 11 at 5,281,550 bp
  • T to A, chromosome 11 at 6,217,807 bp
  • G to A, chromosome 11 at 46,260,832 bp
  • A to T, chromosome 11 at 60,780,354 bp
  • T to C, chromosome 11 at 65,011,932 bp
  • T to A, chromosome 11 at 97,098,893 bp
  • T to C, chromosome 11 at 116,331,993 bp
  • T to C, chromosome 12 at 114,141,092 bp
  • T to C, chromosome 13 at 14,019,795 bp
  • A to G, chromosome 14 at 50,140,450 bp
  • A to G, chromosome 14 at 56,060,668 bp
  • G to T, chromosome 14 at 56,465,654 bp
  • A to T, chromosome 14 at 56,614,759 bp
  • A to T, chromosome 14 at 75,086,297 bp
  • T to A, chromosome 15 at 77,585,273 bp
  • A to G, chromosome 15 at 80,452,544 bp
  • G to A, chromosome 15 at 99,933,640 bp
  • A to C, chromosome 15 at 102,298,896 bp
  • T to A, chromosome 16 at 13,132,947 bp
  • T to A, chromosome 16 at 17,640,971 bp
  • T to A, chromosome 16 at 44,357,896 bp
  • T to C, chromosome 16 at 87,427,603 bp
  • C to T, chromosome 17 at 24,426,740 bp
  • C to A, chromosome 17 at 35,868,211 bp
  • C to G, chromosome 17 at 54,293,001 bp
  • T to C, chromosome 18 at 33,205,534 bp
  • T to A, chromosome 18 at 35,579,019 bp
  • C to A, chromosome 18 at 37,825,077 bp
  • T to C, chromosome 19 at 10,065,598 bp
  • T to C, chromosome 19 at 12,240,725 bp
  • A to T, chromosome 19 at 39,995,546 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7062 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045158-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.