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Strain Name:
C57BL/6J-MtgxR7071Btlr/Mmmh
Stock Number:
045167-MU
Citation ID:
RRID:MMRRC_045167-MU
Other Names:
R7071 (G1)
Major Collection:

Strain Information

Gtf2i
Name: general transcription factor II I
Synonyms: TFII-I, BAP-135, 6030441I21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14886
HGNC: HGNC:4659
Homologene: 7748
Mfn1
Name: mitofusin 1
Synonyms: 6330416C07Rik, 2310002F04Rik, D3Ertd265e, HR2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67414
Homologene: 11481
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CLICK-III, CaMKIgamma
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Ipo11
Name: importin 11
Synonyms: E330021B14Rik, 1700081H05Rik, 2510001A17Rik, Ranbp11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76582
Homologene: 7089
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Cobl
Name: cordon-bleu WH2 repeat
Synonyms: C530045F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12808
Homologene: 9058
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77721
Homologene: 32726
Cc2d2a
Name: coiled-coil and C2 domain containing 2A
Synonyms: 5730509K17Rik, b2b1035Clo
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231214
Homologene: 18159
Stt3b
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
Synonyms: Simp, 1300006C19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68292
VEGA: 9
Homologene: 7387
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98403
Homologene: 9188
Cd300a
Name: CD300A molecule
Synonyms: Pigr4, MMAC8, Clm8, LMIR1, B230315M08Rik, MAIR-I
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217303
Homologene: 48514
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Khsrp
Name: KH-type splicing regulatory protein
Synonyms: 6330409F21Rik, KSRP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16549
VEGA: 17
HGNC: HGNC:6316
Homologene: 2734
Ndfip2
Name: Nedd4 family interacting protein 2
Synonyms: 0710001O20Rik, 9130207N19Rik, N4wbp5a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76273
Homologene: 12636
Atrip
Name: ATR interacting protein
Synonyms: 6620401K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235610
Homologene: 15601
Ythdc2
Name: YTH domain containing 2
Synonyms: 3010002F02Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240255
Homologene: 11265
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235048
Homologene: 138456
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: ZNFPR1B1, Prdm3, MDS1-EVI1, Evi-1, D630039M04Rik, Jbo, Evi1, Mds1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Astl
Name: astacin like metalloendopeptidase
Synonyms: C87576, Ovastacin, Sas1b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215095
Homologene: 128191
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Dnm3
Name: dynamin 3
Synonyms: B230343F03Rik, 9630020E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Abi3bp
Name: ABI family member 3 binding protein
Synonyms: 5033411B22Rik, D930038M13Rik, eratin, TARSH
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320712
VEGA: 16
Homologene: 134172
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: 1600029H12Rik, Psg30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Or2ak5
Name: olfactory receptor family 2 subfamily AK member 5
Synonyms: GA_x6K02T2NKPP-692816-693736, MOR285-1, Olfr318
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258494
Homologene: 133825
Zfp456
Name: zinc finger protein 456
Synonyms: Rslcan-13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408065
Homologene: 110878
Ifitm3
Name: interferon induced transmembrane protein 3
Synonyms: mil-1, 1110004C05Rik, Fgls, IP15, fragilis
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66141
HGNC: HGNC:5414
Homologene: 136199
Gatad1
Name: GATA zinc finger domain containing 1
Synonyms: 2810047M21Rik, 2310031E19Rik, B330017N08Rik, 8430439A17Rik, Odag, 9130430G15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67210
Homologene: 56916
Krtap2-22
Name: keratin associated protein 2-22
Synonyms: Gm11938
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100041412
Homologene: 41961
Arl2bp
Name: ADP-ribosylation factor-like 2 binding protein
Synonyms: Bart1, 1700027H16Rik, 1700010P10Rik, BART
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 107566
Homologene: 11479
Faiml
Name: Fas apoptotic inhibitory molecule like
Synonyms: Gm6432
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 623459
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 33,776,744 bp
  • A to T, chromosome 1 at 75,260,619 bp
  • A to T, chromosome 1 at 150,604,102 bp
  • A to T, chromosome 1 at 162,019,843 bp
  • A to T, chromosome 1 at 193,359,809 bp
  • T to G, chromosome 2 at 41,408,264 bp
  • T to C, chromosome 2 at 101,643,462 bp
  • T to C, chromosome 2 at 127,345,965 bp
  • T to A, chromosome 2 at 127,600,852 bp
  • T to G, chromosome 2 at 146,001,912 bp
  • T to G, chromosome 3 at 29,980,708 bp
  • G to A, chromosome 3 at 32,568,395 bp
  • T to A, chromosome 4 at 85,100,385 bp
  • A to T, chromosome 4 at 113,779,080 bp
  • T to C, chromosome 5 at 3,643,540 bp
  • A to G, chromosome 5 at 43,709,113 bp
  • A to G, chromosome 5 at 134,263,621 bp
  • A to G, chromosome 7 at 3,821,668 bp
  • A to T, chromosome 7 at 17,750,652 bp
  • T to A, chromosome 7 at 46,267,323 bp
  • A to G, chromosome 7 at 141,010,524 bp
  • T to G, chromosome 8 at 44,989,108 bp
  • G to T, chromosome 8 at 94,667,166 bp
  • T to C, chromosome 9 at 22,258,096 bp
  • T to A, chromosome 9 at 99,236,347 bp
  • T to C, chromosome 9 at 109,067,014 bp
  • T to C, chromosome 9 at 114,617,719 bp
  • T to C, chromosome 9 at 115,254,017 bp
  • T to G, chromosome 10 at 58,492,837 bp
  • T to A, chromosome 10 at 80,792,245 bp
  • A to G, chromosome 11 at 12,254,795 bp
  • C to A, chromosome 11 at 58,720,158 bp
  • A to G, chromosome 11 at 77,823,827 bp
  • A to T, chromosome 11 at 99,603,084 bp
  • T to C, chromosome 11 at 114,901,273 bp
  • T to C, chromosome 13 at 67,372,777 bp
  • T to A, chromosome 13 at 106,925,096 bp
  • A to C, chromosome 14 at 105,302,326 bp
  • C to T, chromosome 16 at 56,629,140 bp
  • C to A, chromosome 17 at 57,025,386 bp
  • A to G, chromosome 18 at 44,845,788 bp
  • A to T, chromosome 19 at 5,156,374 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7071 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045167-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.