Loading...

Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7133Btlr/Mmmh
Stock Number:
045218-MU
Citation ID:
RRID:MMRRC_045218-MU
Other Names:
R7133 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Scd1
Name: stearoyl-Coenzyme A desaturase 1
Synonyms: stearoyl-CoA desaturase, Scd-1, SCD
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20249
VEGA: 19
Homologene: 74538

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Tanc1
Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Synonyms: 1200003E16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66860
Homologene: 18946

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Slc29a1
Name: solute carrier family 29 (nucleoside transporters), member 1
Synonyms: ENT1, NBMPR-sensitive equilibrative nucleoside transporter, 1200014D21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63959
Homologene: 37985

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 93,621,234 bp
  • G to A, chromosome 1 at 97,645,920 bp
  • A to C, chromosome 1 at 127,365,189 bp
  • T to C, chromosome 1 at 133,090,234 bp
  • T to A, chromosome 1 at 136,260,821 bp
  • A to G, chromosome 1 at 158,572,987 bp
  • A to T, chromosome 1 at 167,631,109 bp
  • A to T, chromosome 2 at 10,402,007 bp
  • T to C, chromosome 2 at 59,797,609 bp
  • C to T, chromosome 2 at 77,929,478 bp
  • A to G, chromosome 2 at 121,453,480 bp
  • T to A, chromosome 2 at 153,764,963 bp
  • T to A, chromosome 2 at 180,472,063 bp
  • T to A, chromosome 3 at 53,572,339 bp
  • T to A, chromosome 3 at 86,394,931 bp
  • TATCTCCTTTTCCAAAAA to TA, chromosome 3 at 88,983,457 bp
  • T to C, chromosome 3 at 93,219,762 bp
  • A to T, chromosome 3 at 95,833,740 bp
  • T to G, chromosome 3 at 107,214,214 bp
  • A to T, chromosome 3 at 144,961,890 bp
  • A to T, chromosome 4 at 9,484,575 bp
  • T to C, chromosome 4 at 57,225,863 bp
  • A to T, chromosome 4 at 134,065,443 bp
  • A to T, chromosome 5 at 53,998,921 bp
  • A to G, chromosome 5 at 87,325,534 bp
  • G to A, chromosome 5 at 92,158,465 bp
  • A to T, chromosome 5 at 104,302,306 bp
  • G to A, chromosome 6 at 33,438,473 bp
  • C to T, chromosome 6 at 52,215,740 bp
  • A to T, chromosome 6 at 83,180,044 bp
  • A to G, chromosome 6 at 85,466,645 bp
  • A to T, chromosome 7 at 6,708,945 bp
  • T to C, chromosome 7 at 10,581,068 bp
  • C to A, chromosome 7 at 13,259,737 bp
  • T to A, chromosome 7 at 19,087,307 bp
  • A to G, chromosome 7 at 36,770,569 bp
  • A to G, chromosome 7 at 102,742,317 bp
  • T to A, chromosome 7 at 103,085,998 bp
  • T to A, chromosome 7 at 104,429,326 bp
  • C to T, chromosome 7 at 109,896,242 bp
  • C to T, chromosome 7 at 118,152,908 bp
  • T to C, chromosome 7 at 141,439,900 bp
  • C to A, chromosome 8 at 45,983,624 bp
  • G to A, chromosome 8 at 92,678,413 bp
  • T to A, chromosome 8 at 117,187,230 bp
  • T to C, chromosome 8 at 125,801,504 bp
  • C to T, chromosome 9 at 18,327,377 bp
  • A to G, chromosome 9 at 18,409,635 bp
  • A to G, chromosome 10 at 5,231,592 bp
  • G to A, chromosome 10 at 59,996,480 bp
  • T to A, chromosome 10 at 79,066,639 bp
  • T to G, chromosome 10 at 79,066,640 bp
  • T to C, chromosome 10 at 80,086,312 bp
  • A to G, chromosome 11 at 67,202,586 bp
  • T to G, chromosome 11 at 84,519,920 bp
  • T to C, chromosome 11 at 103,181,784 bp
  • T to C, chromosome 11 at 116,767,073 bp
  • T to C, chromosome 12 at 79,284,152 bp
  • T to A, chromosome 12 at 87,270,342 bp
  • C to T, chromosome 12 at 87,350,377 bp
  • T to A, chromosome 12 at 101,884,070 bp
  • T to C, chromosome 12 at 114,300,137 bp
  • T to A, chromosome 12 at 114,416,775 bp
  • T to A, chromosome 13 at 32,850,325 bp
  • C to A, chromosome 13 at 34,901,494 bp
  • A to G, chromosome 14 at 20,561,242 bp
  • T to C, chromosome 14 at 29,996,871 bp
  • T to A, chromosome 14 at 30,917,698 bp
  • C to A, chromosome 14 at 31,286,076 bp
  • C to T, chromosome 14 at 37,048,925 bp
  • T to A, chromosome 14 at 55,568,926 bp
  • T to A, chromosome 15 at 12,180,638 bp
  • A to G, chromosome 15 at 30,480,849 bp
  • T to C, chromosome 15 at 76,176,027 bp
  • C to T, chromosome 15 at 79,828,665 bp
  • C to A, chromosome 15 at 88,915,427 bp
  • C to A, chromosome 15 at 96,378,875 bp
  • T to A, chromosome 15 at 99,672,087 bp
  • T to A, chromosome 16 at 3,749,391 bp
  • A to G, chromosome 16 at 31,892,799 bp
  • T to C, chromosome 16 at 59,536,804 bp
  • C to T, chromosome 17 at 21,262,030 bp
  • C to A, chromosome 17 at 23,673,660 bp
  • G to T, chromosome 17 at 32,820,236 bp
  • A to G, chromosome 17 at 45,589,971 bp
  • C to T, chromosome 17 at 56,120,592 bp
  • A to G, chromosome 17 at 56,417,429 bp
  • C to T, chromosome 17 at 67,782,146 bp
  • C to A, chromosome 18 at 12,539,786 bp
  • A to G, chromosome 18 at 80,909,656 bp
  • T to A, chromosome 19 at 8,895,559 bp
  • T to C, chromosome 19 at 44,406,595 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7133 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045218-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.