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Strain Name:
C57BL/6J-MtgxR7173Btlr/Mmmh
Stock Number:
045265-MU
Citation ID:
RRID:MMRRC_045265-MU
Other Names:
R7173 (G1)
Major Collection:

Strain Information

Igf2bp1
Name: insulin-like growth factor 2 mRNA binding protein 1
Synonyms: CRD-BP, Crdbp, IMP-1, Zbp1, D030026A21Rik, D11Moh45, D11Moh40e, IMP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140486
Homologene: 4772
Gaa
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14387
HGNC: HGNC:4065
Homologene: 37268
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Cabin1
Name: calcineurin binding protein 1
Synonyms: Ppp3in, Cain, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 54,766,391 bp
  • T to A, chromosome 1 at 74,264,372 bp
  • G to A, chromosome 1 at 86,386,468 bp
  • T to A, chromosome 1 at 136,479,170 bp
  • C to A, chromosome 1 at 139,731,677 bp
  • A to T, chromosome 2 at 10,105,163 bp
  • T to A, chromosome 2 at 29,983,209 bp
  • T to C, chromosome 2 at 53,114,190 bp
  • C to T, chromosome 2 at 72,441,414 bp
  • G to A, chromosome 2 at 76,794,685 bp
  • G to T, chromosome 2 at 93,642,857 bp
  • A to T, chromosome 2 at 93,813,612 bp
  • G to T, chromosome 2 at 118,871,389 bp
  • G to T, chromosome 2 at 120,740,111 bp
  • C to T, chromosome 2 at 147,042,093 bp
  • T to G, chromosome 2 at 163,438,688 bp
  • T to C, chromosome 3 at 96,580,663 bp
  • A to T, chromosome 3 at 127,684,375 bp
  • T to C, chromosome 4 at 61,671,962 bp
  • A to T, chromosome 4 at 63,729,652 bp
  • A to G, chromosome 4 at 118,448,544 bp
  • G to A, chromosome 4 at 150,468,738 bp
  • A to T, chromosome 5 at 23,464,857 bp
  • G to A, chromosome 5 at 37,091,364 bp
  • A to T, chromosome 5 at 38,452,871 bp
  • A to T, chromosome 5 at 90,260,117 bp
  • A to T, chromosome 5 at 90,786,149 bp
  • G to T, chromosome 5 at 96,778,078 bp
  • T to C, chromosome 5 at 108,132,321 bp
  • A to T, chromosome 5 at 120,634,214 bp
  • T to C, chromosome 6 at 66,776,294 bp
  • A to T, chromosome 6 at 72,577,252 bp
  • A to T, chromosome 6 at 90,072,268 bp
  • T to A, chromosome 6 at 124,061,296 bp
  • T to C, chromosome 6 at 126,864,766 bp
  • C to T, chromosome 7 at 10,274,555 bp
  • A to T, chromosome 7 at 24,533,760 bp
  • T to C, chromosome 7 at 25,068,162 bp
  • A to G, chromosome 7 at 26,558,178 bp
  • T to A, chromosome 7 at 56,203,827 bp
  • C to T, chromosome 7 at 108,255,748 bp
  • T to C, chromosome 7 at 126,579,417 bp
  • T to C, chromosome 8 at 12,639,259 bp
  • G to T, chromosome 8 at 85,055,078 bp
  • A to T, chromosome 8 at 94,588,858 bp
  • G to A, chromosome 8 at 124,305,553 bp
  • A to T, chromosome 9 at 37,661,300 bp
  • A to G, chromosome 9 at 76,259,731 bp
  • A to C, chromosome 10 at 24,774,047 bp
  • A to T, chromosome 10 at 51,628,499 bp
  • A to G, chromosome 10 at 75,746,562 bp
  • A to T, chromosome 10 at 97,693,355 bp
  • T to C, chromosome 11 at 6,620,810 bp
  • T to C, chromosome 11 at 36,041,551 bp
  • T to G, chromosome 11 at 84,164,548 bp
  • T to C, chromosome 11 at 95,968,464 bp
  • T to C, chromosome 11 at 102,771,931 bp
  • C to T, chromosome 11 at 119,278,991 bp
  • G to A, chromosome 12 at 80,177,259 bp
  • T to G, chromosome 12 at 80,955,976 bp
  • G to T, chromosome 12 at 81,559,234 bp
  • T to C, chromosome 12 at 81,953,003 bp
  • T to C, chromosome 12 at 103,646,994 bp
  • C to G, chromosome 12 at 110,601,739 bp
  • T to C, chromosome 12 at 116,363,534 bp
  • A to G, chromosome 14 at 52,112,176 bp
  • A to T, chromosome 14 at 56,384,380 bp
  • C to T, chromosome 15 at 84,949,647 bp
  • T to C, chromosome 15 at 99,101,306 bp
  • T to C, chromosome 15 at 99,945,650 bp
  • T to C, chromosome 16 at 32,762,488 bp
  • T to C, chromosome 16 at 59,345,147 bp
  • T to C, chromosome 17 at 24,705,259 bp
  • C to A, chromosome 17 at 35,114,704 bp
  • C to A, chromosome 17 at 55,996,696 bp
  • A to G, chromosome 18 at 33,464,409 bp
  • T to C, chromosome 19 at 17,477,877 bp
  • G to C, chromosome 19 at 39,170,957 bp
  • G to C, chromosome X at 106,435,073 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7173 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045265-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.