Strain Name:
C57BL/6J-MtgxR7234Btlr/Mmmh
Stock Number:
045304-MU
Citation ID:
RRID:MMRRC_045304-MU
Other Names:
R7234 (G1)
Major Collection:

Strain Information

Cds2
Name: CDP-diacylglycerol synthase 2
Synonyms: 5730450N06Rik, D2Wsu127e, 5730460C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: D12Ertd7e, Dicer1, 1110006F08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Mdm4
Name: transformed mouse 3T3 cell double minute 4
Synonyms: Mdmx, 4933417N07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17248
HGNC: HGNC:6974
Homologene: 1794
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, Phr1, C130061D10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Kiaa1064-hp, Bwq1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330474
Homologene: 87150
Sec16a
Name: SEC16 homolog A, endoplasmic reticulum export factor
Synonyms: C230052J16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227648
Homologene: 10533
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: 2900018K03Rik, an
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Atxn2l
Name: ataxin 2-like
Synonyms: A2LG, A2D, A2lp, A2RP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Akap1
Name: A kinase anchor protein 1
Synonyms: AKAP121, AKAP84, S-AKAP84, DAKAP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11640
HGNC: HGNC:367
Homologene: 31165
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Fzd7
Name: frizzled class receptor 7
Synonyms: Fz7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14369
HGNC: HGNC:4045
Homologene: 20751
Mib2
Name: mindbomb E3 ubiquitin protein ligase 2
Synonyms: 2210008I11Rik, Zzank1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76580
Homologene: 16062
Thra
Name: thyroid hormone receptor alpha
Synonyms: Rvr, 6430529J03Rik, Nr1a1, Thra2, Thra1, T3R[a], T3Ralpha, Erba, TR alpha 2, c-erbAalpha, TR alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Fbxl5
Name: F-box and leucine-rich repeat protein 5
Synonyms: Fbl4, Fir4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242960
Homologene: 8129
Cab39l
Name: calcium binding protein 39-like
Synonyms: 2810425O13Rik, 4930520C08Rik, MO2L, 1500031K13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69008
VEGA: 14
Homologene: 69422
Scamp5
Name: secretory carrier membrane protein 5
Synonyms: Sc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56807
VEGA: 9
Homologene: 56880
Tmem60
Name: transmembrane protein 60
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212090
Homologene: 13165
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Plxna2
Name: plexin A2
Synonyms: Plxn2, 2810428A13Rik, OCT, PlexA2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Ank
Name: progressive ankylosis
Synonyms: D15Ertd221e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11732
Homologene: 10664
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ift70a2
Name: intraflagellar transport 70A2
Synonyms: OTTMUSG00000015167, Ttc30a2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 620631
Homologene: 44342
Gsap
Name: gamma-secretase activating protein
Synonyms: Pion, A530088I07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212167
Homologene: 45504
Gbp5
Name: guanylate binding protein 5
Synonyms: Gbp5a, 5330409J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229898
Homologene: 14183
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22018
Homologene: 461
Gm10306
Name: predicted gene 10306
Type: Gene
Species: Mouse
Chromosome: 4
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Birc1f, Naip-rs4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Cdkn3
Name: cyclin dependent kinase inhibitor 3
Synonyms: KAP, 2410006H10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72391
VEGA: 14
HGNC: HGNC:1791
Homologene: 3805
Dnaaf9
Name: dynein axonemal assembly factor 9
Synonyms: 4930402H24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228602
Homologene: 12623
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: Fir, D030026M03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227377
Homologene: 8877
Cped1
Name: cadherin-like and PC-esterase domain containing 1
Synonyms: A430107O13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214642
Homologene: 57014
Umodl1
Name: uromodulin-like 1
Synonyms: D17Ertd488e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 52020
VEGA: 17
Homologene: 45466
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: Abp1, 1600012D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Lhcgr
Name: luteinizing hormone/choriogonadotropin receptor
Synonyms: Lhr, LH-R, Gpcr19-rs1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16867
VEGA: 17
HGNC: HGNC:6585
Homologene: 37276
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
AI606181
Name: expressed sequence AI606181
Type: Gene
Species: Mouse
Chromosome: 19
Rap1gap
Name: Rap1 GTPase-activating protein
Synonyms: 1300019I11Rik, Rap1ga1, Gap, 2310004O14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110351
HGNC: HGNC:9858
Homologene: 2163
Spem1
Name: spermatid maturation 1
Synonyms: 1700095G12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74288
Homologene: 45717
Apol7c
Name: apolipoprotein L 7c
Synonyms: 2210421G13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 108956
VEGA: 15
HGNC: HGNC:619
Homologene: 40940
Tmem260
Name: transmembrane protein 260
Synonyms: 6720456H20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218989
Homologene: 49506
Ranbp6
Name: RAN binding protein 6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240614
HGNC: HGNC:9851
Homologene: 18935
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: synphilin-1, SYPH1, 4933427B05Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67847
Homologene: 3987
Angpt1
Name: angiopoietin 1
Synonyms: Ang-1, 1110046O21Rik, Angiopoietin-1, ang1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11600
VEGA: 15
HGNC: HGNC:484
Homologene: 37447
Klk13
Name: kallikrein related-peptidase 13
Synonyms: mGk-13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 626834
HGNC: HGNC:6361
Homologene: 56714
Kcnip3
Name: Kv channel interacting protein 3, calsenilin
Synonyms: R74849, 4933407H12Rik, KChIP3, Csen, DREAM
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56461
Homologene: 8382
Acy3
Name: aminoacylase 3
Synonyms: 0610006H10Rik, AA3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71670
VEGA: 19
Homologene: 12401
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Xrra1
Name: X-ray radiation resistance associated 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446101
Homologene: 19547
Fam83g
Name: family with sequence similarity 83, member G
Synonyms: wly, 2310040C09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69640
Homologene: 85169
Or10j5
Name: olfactory receptor family 10 subfamily J member 5
Synonyms: Olfr16, MOR267-13, MOR23, GA_x6K02T2R7CC-893157-892228
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18313
Homologene: 7460
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Edem2
Name: ER degradation enhancer, mannosidase alpha-like 2
Synonyms: 9530090G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108687
Homologene: 10075
Or51v14
Name: olfactory receptor family 51 subfamily V member 14
Synonyms: Olfr620, GA_x6K02T2PBJ9-6335095-6334154, MOR4-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258808
Homologene: 103777
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Ribc2
Name: RIB43A domain with coiled-coils 2
Synonyms: Trib, 4930579A10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67747
VEGA: 15
Homologene: 9230
Ero1b
Name: endoplasmic reticulum oxidoreductase 1 beta
Synonyms: 1300013B24Rik, 1700065B09Rik, Ero1lb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67475
VEGA: 13
Homologene: 8740
Nom1
Name: nucleolar protein with MIF4G domain 1
Synonyms: LOC381627, Gm1040, D5Kng1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433864
Homologene: 39776
Kcnrg
Name: potassium channel regulator
Synonyms: LOC328424, E030012H22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328424
VEGA: 14
Homologene: 35259
Cideb
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector B
Synonyms: CIDE-B, 1110030C18Rik, DFFA-like B
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12684
HGNC: HGNC:1977
Homologene: 7666
Msantd5f9
Name: Myb/SANT DNA binding domain containing 5 family member 9
Synonyms: Gm11756
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 623281
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 59,483,284 bp
  • A to G, chromosome 1 at 93,580,119 bp
  • A to G, chromosome 1 at 97,125,741 bp
  • A to T, chromosome 1 at 133,011,115 bp
  • T to A, chromosome 1 at 172,957,106 bp
  • A to T, chromosome 1 at 194,806,390 bp
  • G to T, chromosome 2 at 26,439,768 bp
  • A to T, chromosome 2 at 75,976,196 bp
  • C to A, chromosome 2 at 127,521,336 bp
  • C to A, chromosome 2 at 130,806,788 bp
  • T to C, chromosome 2 at 132,304,480 bp
  • A to T, chromosome 2 at 155,710,966 bp
  • A to T, chromosome 3 at 142,521,137 bp
  • A to G, chromosome 4 at 70,376,787 bp
  • G to T, chromosome 4 at 73,917,571 bp
  • T to A, chromosome 4 at 94,556,795 bp
  • A to G, chromosome 4 at 128,456,779 bp
  • T to A, chromosome 4 at 137,728,540 bp
  • C to T, chromosome 4 at 141,479,135 bp
  • G to T, chromosome 4 at 155,657,893 bp
  • T to A, chromosome 5 at 20,886,621 bp
  • A to G, chromosome 5 at 21,186,435 bp
  • A to G, chromosome 5 at 29,435,453 bp
  • A to G, chromosome 5 at 43,758,220 bp
  • A to G, chromosome 5 at 64,926,724 bp
  • G to T, chromosome 5 at 121,329,073 bp
  • A to G, chromosome 6 at 22,254,626 bp
  • C to T, chromosome 6 at 48,905,816 bp
  • G to A, chromosome 7 at 16,429,036 bp
  • T to C, chromosome 7 at 43,721,417 bp
  • T to C, chromosome 7 at 85,407,107 bp
  • A to G, chromosome 7 at 97,530,300 bp
  • G to A, chromosome 7 at 99,914,249 bp
  • A to G, chromosome 7 at 103,611,882 bp
  • A to G, chromosome 7 at 126,493,201 bp
  • T to A, chromosome 9 at 27,050,359 bp
  • C to A, chromosome 9 at 57,447,140 bp
  • T to A, chromosome 9 at 65,135,468 bp
  • T to C, chromosome 10 at 118,860,231 bp
  • T to C, chromosome 11 at 61,702,516 bp
  • A to G, chromosome 11 at 69,821,804 bp
  • T to C, chromosome 11 at 88,838,982 bp
  • T to C, chromosome 11 at 98,763,718 bp
  • G to A, chromosome 12 at 30,092,686 bp
  • T to A, chromosome 12 at 40,080,958 bp
  • A to G, chromosome 12 at 104,708,849 bp
  • A to T, chromosome 13 at 12,600,314 bp
  • A to T, chromosome 13 at 100,315,503 bp
  • T to C, chromosome 14 at 46,771,461 bp
  • T to A, chromosome 14 at 48,505,329 bp
  • C to T, chromosome 14 at 55,754,560 bp
  • T to A, chromosome 14 at 59,496,946 bp
  • A to T, chromosome 14 at 61,608,082 bp
  • A to T, chromosome 14 at 103,215,337 bp
  • T to C, chromosome 15 at 27,571,656 bp
  • T to C, chromosome 15 at 42,459,725 bp
  • A to T, chromosome 15 at 77,525,675 bp
  • A to G, chromosome 15 at 85,135,532 bp
  • T to A, chromosome 16 at 34,176,422 bp
  • G to A, chromosome 16 at 36,757,811 bp
  • A to G, chromosome 17 at 30,986,621 bp
  • A to T, chromosome 17 at 88,791,931 bp
  • C to T, chromosome 18 at 52,915,344 bp
  • T to A, chromosome 19 at 3,987,758 bp
  • T to C, chromosome 19 at 29,812,062 bp
  • C to A, chromosome 19 at 37,290,785 bp
  • T to A, chromosome 19 at 41,593,637 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7234 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045304-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.