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Strain Name:
C57BL/6J-MtgxR7234Btlr/Mmmh
Stock Number:
045304-MU
Citation ID:
RRID:MMRRC_045304-MU
Other Names:
R7234 (G1)
Major Collection:

Strain Information

Cds2
Name: CDP-diacylglycerol synthase 2
Synonyms: 5730460C18Rik, D2Wsu127e, 5730450N06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110911
HGNC: HGNC:1801
Homologene: 37854
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: 1110006F08Rik, D12Ertd7e, Dicer1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Mdm4
Name: transformed mouse 3T3 cell double minute 4
Synonyms: Mdmx, 4933417N07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17248
HGNC: HGNC:6974
Homologene: 1794
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330474
Homologene: 87150
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 59,483,284 bp
  • A to G, chromosome 1 at 93,580,119 bp
  • A to G, chromosome 1 at 97,125,741 bp
  • A to T, chromosome 1 at 133,011,115 bp
  • T to A, chromosome 1 at 172,957,106 bp
  • A to T, chromosome 1 at 194,806,390 bp
  • G to T, chromosome 2 at 26,439,768 bp
  • A to T, chromosome 2 at 75,976,196 bp
  • C to A, chromosome 2 at 127,521,336 bp
  • C to A, chromosome 2 at 130,806,788 bp
  • T to C, chromosome 2 at 132,304,480 bp
  • A to T, chromosome 2 at 155,710,966 bp
  • A to T, chromosome 3 at 142,521,137 bp
  • A to G, chromosome 4 at 70,376,787 bp
  • G to T, chromosome 4 at 73,917,571 bp
  • T to A, chromosome 4 at 94,556,795 bp
  • A to G, chromosome 4 at 128,456,779 bp
  • T to A, chromosome 4 at 137,728,540 bp
  • C to T, chromosome 4 at 141,479,135 bp
  • G to T, chromosome 4 at 155,657,893 bp
  • T to A, chromosome 5 at 20,886,621 bp
  • A to G, chromosome 5 at 21,186,435 bp
  • A to G, chromosome 5 at 29,435,453 bp
  • A to G, chromosome 5 at 43,758,220 bp
  • A to G, chromosome 5 at 64,926,724 bp
  • G to T, chromosome 5 at 121,329,073 bp
  • A to G, chromosome 6 at 22,254,626 bp
  • C to T, chromosome 6 at 48,905,816 bp
  • G to A, chromosome 7 at 16,429,036 bp
  • T to C, chromosome 7 at 43,721,417 bp
  • T to C, chromosome 7 at 85,407,107 bp
  • A to G, chromosome 7 at 97,530,300 bp
  • G to A, chromosome 7 at 99,914,249 bp
  • A to G, chromosome 7 at 103,611,882 bp
  • A to G, chromosome 7 at 126,493,201 bp
  • T to A, chromosome 9 at 27,050,359 bp
  • C to A, chromosome 9 at 57,447,140 bp
  • T to A, chromosome 9 at 65,135,468 bp
  • T to C, chromosome 10 at 118,860,231 bp
  • T to C, chromosome 11 at 61,702,516 bp
  • A to G, chromosome 11 at 69,821,804 bp
  • T to C, chromosome 11 at 88,838,982 bp
  • T to C, chromosome 11 at 98,763,718 bp
  • G to A, chromosome 12 at 30,092,686 bp
  • T to A, chromosome 12 at 40,080,958 bp
  • A to G, chromosome 12 at 104,708,849 bp
  • A to T, chromosome 13 at 12,600,314 bp
  • A to T, chromosome 13 at 100,315,503 bp
  • T to C, chromosome 14 at 46,771,461 bp
  • T to A, chromosome 14 at 48,505,329 bp
  • C to T, chromosome 14 at 55,754,560 bp
  • T to A, chromosome 14 at 59,496,946 bp
  • A to T, chromosome 14 at 61,608,082 bp
  • A to T, chromosome 14 at 103,215,337 bp
  • T to C, chromosome 15 at 27,571,656 bp
  • T to C, chromosome 15 at 42,459,725 bp
  • A to T, chromosome 15 at 77,525,675 bp
  • A to G, chromosome 15 at 85,135,532 bp
  • T to A, chromosome 16 at 34,176,422 bp
  • G to A, chromosome 16 at 36,757,811 bp
  • A to G, chromosome 17 at 30,986,621 bp
  • A to T, chromosome 17 at 88,791,931 bp
  • C to T, chromosome 18 at 52,915,344 bp
  • T to A, chromosome 19 at 3,987,758 bp
  • T to C, chromosome 19 at 29,812,062 bp
  • C to A, chromosome 19 at 37,290,785 bp
  • T to A, chromosome 19 at 41,593,637 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7234 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045304-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.