Strain Name:
C57BL/6J-MtgxR7212Btlr/Mmmh
Stock Number:
045340-MU
Citation ID:
RRID:MMRRC_045340-MU
Other Names:
R7212 (G1)
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, ETR-b, Sox10m1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: neuroaxonal dystrophy, ROSA62, SpbIV, nmf261, 1700022P15Rik, Spnb4, dyn, 5830426A08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: Trb, 5830465M17Rik, Che-1, 4933415H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Fgf4
Name: fibroblast growth factor 4
Synonyms: Hstf-1, Fgf-4, Hst1, kFGF, Fgfk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14175
HGNC: HGNC:3682
Homologene: 1522
Ckm
Name: creatine kinase, muscle
Synonyms: Ckmm, M-CK, MCK
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12715
HGNC: HGNC:1994
Homologene: 20432
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: 2410030O07Rik, B930014J03Rik, Bmn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, Tweek, FSA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Cog7
Name: component of oligomeric golgi complex 7
Synonyms: 5630400E24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233824
Homologene: 33431
Armc10
Name: armadillo repeat containing 10
Synonyms: 2810037C14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67211
Homologene: 12097
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Lhx4
Name: LIM homeobox protein 4
Synonyms: Gsh-4, Gsh4, A330062J17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16872
Homologene: 56497
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: Membrane type 1-MMP, MT1-MMP, sabe
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Tpm3
Name: tropomyosin 3, gamma
Synonyms: hTM30nm, hTMnm, Tm5NM, skalphaTM.2, Trop-5, gamma-TM, Tpm5, Tpm-5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59069
Homologene: 81889
Cdhr5
Name: cadherin-related family member 5
Synonyms: Mucdhl, Mupcdh, 1810074H01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72040
HGNC: HGNC:7521
Homologene: 69345
Coq7
Name: demethyl-Q 7
Synonyms: clk-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12850
HGNC: HGNC:2244
Homologene: 6953
Chordc1
Name: cysteine and histidine rich domain containing 1
Synonyms: Chp-1, 1110001O09Rik, morgana
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66917
VEGA: 9
Homologene: 8111
Nbeal1
Name: neurobeachin like 1
Synonyms: A530050O19Rik, 2310076G13Rik, ALS2CR17, A530083I02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269198
Homologene: 16453
Cp
Name: ceruloplasmin
Synonyms: D3Ertd555e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12870
HGNC: HGNC:2295
Homologene: 75
Adamts13
Name: ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms: LOC279028, vWF-CP mRNA for von Willebrand factor-cleaving
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 279028
HGNC: HGNC:1366
Homologene: 16372
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: NMF355, nmf355, SMCC1, Clc-1, Clc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Hipk1
Name: homeodomain interacting protein kinase 1
Synonyms: 1110062K04Rik, Myak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15257
Homologene: 56483
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, Nav1.5c, SkM2, mH1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320664
Homologene: 75128
Dcst2
Name: DC-STAMP domain containing 2
Synonyms: LOC329702
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329702
Homologene: 16951
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Cyp2d10
Name: cytochrome P450, family 2, subfamily d, polypeptide 10
Synonyms: Cyp2d, P450-2D
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13101
VEGA: 15
Homologene: 86099
Zfp217
Name: zinc finger protein 217
Synonyms: 4933431C08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228913
Homologene: 4757
Naalad2
Name: N-acetylated alpha-linked acidic dipeptidase 2
Synonyms: GCP3, Folh1b, NAALADASE2, NAADALASE2, D9Ertd285e, GCPIII
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72560
Homologene: 3294
Psg23
Name: pregnancy-specific beta-1-glycoprotein 23
Synonyms: 1620401C02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56868
HGNC: HGNC:1819
Homologene: 110989
1700003E16Rik
Name: RIKEN cDNA 1700003E16 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71837
Homologene: 52846
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Atp6n1a, Atp6n1, V-ATPase a1, Vpp1, Vpp-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Igsf9b
Name: immunoglobulin superfamily, member 9B
Synonyms: AI414108, LOC235086
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235086
Homologene: 19472
Bap1
Name: Brca1 associated protein 1
Synonyms: 2300006C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 104416
HGNC: HGNC:950
Homologene: 3421
Ccdc40
Name: coiled-coil domain containing 40
Synonyms: B930008I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207607
Homologene: 27890
Actl11
Name: actin-like 11
Synonyms: 4921517D21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67722
Homologene: 69412
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Slc27a1
Name: solute carrier family 27 (fatty acid transporter), member 1
Synonyms: FATP1, Fatp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26457
Homologene: 8063
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: MDC-L, D430033C21Rik, C130072N01Rik, Dtgn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Cenpj
Name: centromere protein J
Synonyms: Sas4, 4932437H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219103
Homologene: 10204
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: Pacs1l, 6720425G15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Or7a38
Name: olfactory receptor family 7 subfamily A member 38
Synonyms: Olfr233-ps1, Olfr1354, MOR139-5, GA_x6K02T03FR9-4826-3919, MOR185-8, MOR139-7, GA_x6K02T2QGN0-2895081-2894349, EG257869
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259163
Homologene: 136441
Rfpl4
Name: ret finger protein-like 4
Synonyms: D7Ertd486e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 192658
Homologene: 90101
Or8b35
Name: olfactory receptor family 8 subfamily B member 35
Synonyms: MOR162-7, Olfr881, GA_x6K02T2PVTD-31676771-31677700
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258413
Homologene: 74013
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22238
Homologene: 137225
Abcd2
Name: ATP-binding cassette, sub-family D member 2
Synonyms: ALDL1, ABC39, adrenoleukodystrophy related, ALDR
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, Clca3, gob-5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Gcm1
Name: glial cells missing homolog 1
Synonyms: GCMa, glide, Gcm a, glial cell deficient, Gcm1-rs1, Gcm 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14531
VEGA: 9
HGNC: HGNC:4197
Homologene: 2702
Meltf
Name: melanotransferrin
Synonyms: melanotransferrin, Mfi2, CD228, MTf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Arhgap27
Name: Rho GTPase activating protein 27
Synonyms: 2310069I04Rik, 5730442P18Rik, Sh3d20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544817
Homologene: 45715
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: Galnt19, Wbscr17, Gcap8, E330012B09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212996
Homologene: 49707
Clec4a4
Name: C-type lectin domain family 4, member a4
Synonyms: Dcir2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 474145
Homologene: 133910
Arhgap8
Name: Rho GTPase activating protein 8
Synonyms: 3110043J09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73167
Homologene: 23645
Wfdc11
Name: WAP four-disulfide core domain 11
Synonyms: OTTMUSG00000016290
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629761
Homologene: 136267
Tmod1
Name: tropomodulin 1
Synonyms: E-Tmod, erythrocyte tropomodulin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21916
Homologene: 20701
Runx3
Name: runt related transcription factor 3
Synonyms: Rx3, Cbfa3, AML2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12399
Homologene: 37914
Dpt
Name: dermatopontin
Synonyms: 5033416F05Rik, 1810032B19Rik, early quiescence protein-1, EQ-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56429
HGNC: HGNC:3011
Homologene: 1458
Gdi1
Name: GDP dissociation inhibitor 1
Synonyms: GDIA, Rab GDIalpha
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 14567
HGNC: HGNC:4226
Homologene: 37487
Gm49358
Name: predicted gene, 49358
Type: Gene
Species: Mouse
Chromosome: 10
G530012D18Rik
Name: RIKEN cDNA G530012D1 gene
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 60,237,151 bp
  • A to T, chromosome 1 at 85,577,143 bp
  • G to T, chromosome 1 at 155,724,953 bp
  • A to T, chromosome 1 at 164,796,915 bp
  • T to A, chromosome 2 at 27,006,314 bp
  • T to C, chromosome 2 at 60,634,654 bp
  • T to C, chromosome 2 at 164,664,446 bp
  • A to T, chromosome 2 at 170,114,152 bp
  • T to A, chromosome 2 at 172,427,186 bp
  • T to C, chromosome 3 at 19,974,966 bp
  • C to A, chromosome 3 at 37,048,009 bp
  • A to G, chromosome 3 at 89,366,300 bp
  • G to A, chromosome 3 at 90,091,054 bp
  • G to A, chromosome 3 at 103,777,610 bp
  • A to G, chromosome 3 at 135,567,635 bp
  • A to C, chromosome 3 at 145,005,966 bp
  • A to T, chromosome 4 at 46,093,951 bp
  • A to G, chromosome 4 at 86,802,991 bp
  • T to A, chromosome 4 at 135,152,779 bp
  • T to C, chromosome 5 at 21,660,583 bp
  • A to T, chromosome 5 at 87,125,272 bp
  • T to A, chromosome 5 at 123,973,782 bp
  • T to C, chromosome 5 at 130,964,111 bp
  • T to C, chromosome 6 at 42,291,389 bp
  • T to C, chromosome 6 at 58,918,773 bp
  • C to T, chromosome 6 at 83,161,672 bp
  • T to A, chromosome 6 at 122,991,745 bp
  • C to A, chromosome 7 at 5,110,660 bp
  • A to G, chromosome 7 at 18,607,139 bp
  • T to C, chromosome 7 at 19,415,053 bp
  • T to G, chromosome 7 at 27,416,785 bp
  • A to G, chromosome 7 at 118,510,048 bp
  • T to C, chromosome 7 at 121,977,314 bp
  • C to T, chromosome 7 at 141,272,659 bp
  • A to G, chromosome 7 at 144,862,786 bp
  • A to T, chromosome 8 at 33,570,826 bp
  • T to C, chromosome 8 at 33,572,995 bp
  • T to C, chromosome 8 at 71,584,448 bp
  • T to A, chromosome 9 at 18,295,351 bp
  • T to C, chromosome 9 at 18,301,012 bp
  • T to C, chromosome 9 at 18,364,041 bp
  • C to T, chromosome 9 at 27,331,696 bp
  • T to A, chromosome 9 at 37,992,957 bp
  • A to T, chromosome 9 at 78,059,643 bp
  • T to A, chromosome 9 at 107,928,657 bp
  • A to G, chromosome 9 at 118,536,840 bp
  • A to T, chromosome 9 at 119,543,385 bp
  • A to G, chromosome 10 at 76,501,311 bp
  • A to T, chromosome 10 at 78,917,505 bp
  • A to T, chromosome 10 at 79,379,434 bp
  • G to T, chromosome 10 at 86,825,207 bp
  • A to G, chromosome 11 at 9,298,854 bp
  • C to T, chromosome 11 at 84,449,180 bp
  • T to C, chromosome 11 at 101,043,957 bp
  • C to T, chromosome 11 at 103,360,755 bp
  • A to G, chromosome 11 at 119,264,444 bp
  • A to G, chromosome 12 at 113,061,692 bp
  • T to A, chromosome 14 at 31,251,623 bp
  • T to G, chromosome 14 at 54,435,879 bp
  • A to G, chromosome 14 at 56,552,652 bp
  • T to A, chromosome 14 at 68,637,397 bp
  • T to A, chromosome 14 at 103,843,008 bp
  • C to T, chromosome 15 at 12,146,223 bp
  • A to T, chromosome 15 at 53,345,162 bp
  • T to A, chromosome 15 at 82,404,246 bp
  • T to G, chromosome 15 at 84,745,792 bp
  • C to T, chromosome 15 at 91,159,123 bp
  • T to A, chromosome 16 at 31,890,814 bp
  • T to C, chromosome 19 at 18,853,791 bp
  • G to A, chromosome X at 74,306,855 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7212 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045340-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.