Strain Name:
C57BL/6J-MtgxR7273Btlr/Mmmh
Stock Number:
045357-MU
Citation ID:
RRID:MMRRC_045357-MU
Other Names:
R7273 (G1)
Major Collection:

Strain Information

Prdm16
Name: PR domain containing 16
Synonyms: 5730557K01Rik, csp1, line 27, Mel1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70673
Homologene: 11139
Rfx3
Name: regulatory factor X, 3 (influences HLA class II expression)
Synonyms: C230093O12Rik, MRFX3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19726
HGNC: HGNC:9984
Homologene: 7917
Mga
Name: MAX gene associated
Synonyms: Mga, D030062C11Rik, C130042M01Rik, Mad5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Pum1
Name: pumilio RNA-binding family member 1
Synonyms: Pumm
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 80912
Homologene: 22830
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 4930431J08Rik, 9330107J05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Prepl
Name: prolyl endopeptidase-like
Synonyms: 2810457N15Rik, 9530014L06Rik, D030028O16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213760
VEGA: 17
Homologene: 15481
Nisch
Name: nischarin
Synonyms: edsn, 3202002H23Rik, 1200007D05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Ubr3
Name: ubiquitin protein ligase E3 component n-recognin 3
Synonyms: A130030D10Rik, Zfp650, 4833421P10Rik, 1110059H15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68795
Homologene: 52092
Aspn
Name: asporin
Synonyms: SLRR1C, PLAP-1, 4631401G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66695
VEGA: 13
Homologene: 32357
Slc49a3
Name: solute carrier family 49 member 3
Synonyms: 4732482E20Rik, Mfsd7a, Mfsd7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243197
VEGA: 5
Homologene: 49990
Il6st
Name: interleukin 6 signal transducer
Synonyms: 5133400A03Rik, CD130, D13Ertd699e, gp130
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Rab10
Name: RAB10, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19325
VEGA: 12
HGNC: HGNC:9759
Homologene: 41111
Mapk8ip3
Name: mitogen-activated protein kinase 8 interacting protein 3
Synonyms: Syd2, Jip3, JNK-interacting protein 3, JUN/SAPK-associated protein 1, JSAP1d, JSAP1c, JSAP1b, JSAP1a, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, JSAP1, sunday driver 2, D17Wsu15e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30957
HGNC: HGNC:6884
Homologene: 22790
Eea1
Name: early endosome antigen 1
Synonyms: ZFYVE2, A430109M19Rik, B230358H09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, Ugcgl1, 0910001L17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Umod
Name: uromodulin
Synonyms: Tamm-Horsfall glycoprotein, uromucoid, urehr4, Urehd1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22242
Homologene: 2522
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Zhx2
Name: zinc fingers and homeoboxes 2
Synonyms: Raf, Afr-1, Afr1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 387609
Homologene: 8968
Chrd
Name: chordin
Synonyms: Chd
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12667
HGNC: HGNC:1949
Homologene: 2774
Il1r2
Name: interleukin 1 receptor, type II
Synonyms: IL-1 receptor beta chain, CD121b, Il1r-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16178
HGNC: HGNC:5994
Homologene: 7783
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: 1110008N23Rik, A930030P13Rik, heco, ELP79
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Zfp787
Name: zinc finger protein 787
Synonyms: 2210018M03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67109
Homologene: 18983
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, EG235580, Vwa6, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Nuggc
Name: nuclear GTPase, germinal center associated
Synonyms: LOC239151, Gm600, SLIP-GC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100503545
Homologene: 72641
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Npc1l1
Name: NPC1 like intracellular cholesterol transporter 1
Synonyms: Niemann-Pick disease, type C1, 9130221N23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237636
HGNC: HGNC:7898
Homologene: 56585
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Sema5a
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Synonyms: 9130201M22Rik, semF, M-Sema D, Semaf
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20356
VEGA: 15
Homologene: 2949
Mcam
Name: melanoma cell adhesion molecule
Synonyms: s-endo, 1-gicerin, CD146, Muc18, s-gicerin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84004
HGNC: HGNC:6934
Homologene: 4742
Lrrn4
Name: leucine rich repeat neuronal 4
Synonyms: B430119L13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320974
Homologene: 17632
Apol10a
Name: apolipoprotein L 10A
Synonyms: 9030421J09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 245282
Homologene: 129975
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Gm101, Pcdp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Tmprss11d
Name: transmembrane protease, serine 11d
Synonyms: AsP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231382
Homologene: 74519
Tubal3
Name: tubulin, alpha-like 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238463
VEGA: 13
Homologene: 23488
Lrrc56
Name: leucine rich repeat containing 56
Synonyms: 5730427C23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70552
Homologene: 115748
Or10g6
Name: olfactory receptor family 10 subfamily G member 6
Synonyms: GA_x6K02T2PVTD-33720892-33721824, MOR223-8, Olfr981
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258283
VEGA: 9
Homologene: 64849
Top1mt
Name: DNA topoisomerase 1, mitochondrial
Synonyms: 2900052H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72960
Homologene: 43082
Sycp3
Name: synaptonemal complex protein 3
Synonyms: Scp3, Cor1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20962
Homologene: 7964
Tdpoz8
Name: TD and POZ domain containing 8
Synonyms: Gm4858
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229571
Homologene: 130121
Otud1
Name: OTU domain containing 1
Synonyms: 4933428L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71198
Homologene: 45953
Uqcc5
Name: ubiquinol-cytochrome c reductase complex assembly factor 5
Synonyms: 2010107H07Rik, Smim4, Gm41122
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66487
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Kif19b
Name: kinesin family member 19B
Synonyms: Gm4869
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 101055939
Homologene: 82478
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,162,221 bp
  • A to G, chromosome 1 at 40,112,007 bp
  • C to T, chromosome 1 at 63,303,404 bp
  • A to T, chromosome 1 at 119,954,218 bp
  • A to G, chromosome 2 at 19,659,062 bp
  • G to A, chromosome 2 at 69,979,333 bp
  • T to C, chromosome 2 at 119,935,214 bp
  • T to C, chromosome 2 at 132,879,829 bp
  • A to G, chromosome 3 at 90,118,547 bp
  • G to T, chromosome 3 at 93,074,168 bp
  • T to A, chromosome 4 at 47,284,467 bp
  • T to C, chromosome 4 at 130,751,480 bp
  • A to G, chromosome 4 at 154,345,453 bp
  • T to C, chromosome 5 at 14,681,594 bp
  • A to T, chromosome 5 at 86,337,239 bp
  • T to C, chromosome 5 at 108,441,991 bp
  • T to C, chromosome 5 at 125,023,623 bp
  • T to A, chromosome 5 at 140,476,012 bp
  • A to T, chromosome 7 at 6,133,040 bp
  • T to A, chromosome 7 at 105,406,965 bp
  • T to C, chromosome 7 at 119,477,027 bp
  • T to C, chromosome 7 at 141,209,665 bp
  • G to A, chromosome 7 at 141,851,570 bp
  • A to T, chromosome 9 at 40,022,665 bp
  • T to C, chromosome 9 at 44,140,944 bp
  • A to G, chromosome 9 at 106,000,457 bp
  • A to T, chromosome 10 at 88,469,566 bp
  • G to T, chromosome 10 at 95,989,631 bp
  • A to G, chromosome 11 at 6,218,320 bp
  • A to T, chromosome 11 at 119,431,756 bp
  • G to T, chromosome 12 at 3,256,891 bp
  • A to G, chromosome 12 at 108,538,173 bp
  • T to A, chromosome 13 at 3,930,675 bp
  • A to T, chromosome 13 at 49,558,876 bp
  • G to A, chromosome 13 at 59,717,632 bp
  • T to C, chromosome 13 at 112,495,298 bp
  • G to T, chromosome 14 at 31,124,598 bp
  • A to G, chromosome 14 at 31,174,407 bp
  • A to G, chromosome 14 at 65,619,608 bp
  • A to G, chromosome 15 at 32,417,462 bp
  • C to T, chromosome 15 at 57,823,428 bp
  • A to G, chromosome 15 at 75,664,082 bp
  • A to T, chromosome 15 at 77,488,868 bp
  • G to A, chromosome 16 at 20,741,566 bp
  • A to T, chromosome 17 at 24,906,174 bp
  • A to T, chromosome 17 at 29,969,938 bp
  • A to C, chromosome 17 at 85,081,992 bp
  • C to T, chromosome 19 at 27,802,458 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7273 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045357-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.