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Strain Name:
C57BL/6J-MtgxR7311Btlr/Mmmh
Stock Number:
045367-MU
Citation ID:
RRID:MMRRC_045367-MU
Other Names:
R7311 (G1)
Major Collection:

Strain Information

Kifc2
Name: kinesin family member C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16581
VEGA: 15
Homologene: 7800
Mrtfb
Name: myocardin related transcription factor B
Synonyms: MRTF-B, Gt4-1, Mrtfb, Mkl2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239719
Homologene: 40917
Epyc
Name: epiphycan
Synonyms: PG-Lb, epiphycan, SLRR3B, Dspg3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13516
HGNC: HGNC:3053
Homologene: 3634
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Socs3
Name: suppressor of cytokine signaling 3
Synonyms: EF-10, SOCS-3, cytokine-inducible SH2 protein 3, CIS3, STAT-induced STAT inhibitor 3, SSI-3, E2a-Pbx1 target gene in fibroblasts 10, Cish3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12702
Homologene: 2941
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Dock5
Name: dedicator of cytokinesis 5
Synonyms: lr2, 1110060D06Rik, rlc
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 68813
VEGA: 14
Homologene: 57016
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 74,951,147 bp
  • C to T, chromosome 1 at 90,822,291 bp
  • T to A, chromosome 1 at 91,323,568 bp
  • A to T, chromosome 1 at 106,791,704 bp
  • A to G, chromosome 1 at 107,546,747 bp
  • T to A, chromosome 1 at 173,759,568 bp
  • T to C, chromosome 1 at 174,369,193 bp
  • A to T, chromosome 1 at 191,357,801 bp
  • T to A, chromosome 1 at 192,980,550 bp
  • C to A, chromosome 2 at 66,484,404 bp
  • A to G, chromosome 2 at 79,256,182 bp
  • C to T, chromosome 2 at 93,865,815 bp
  • C to A, chromosome 2 at 113,525,680 bp
  • T to C, chromosome 2 at 154,857,420 bp
  • T to C, chromosome 3 at 88,711,695 bp
  • T to C, chromosome 3 at 103,997,664 bp
  • T to A, chromosome 3 at 146,507,163 bp
  • A to G, chromosome 4 at 41,498,577 bp
  • A to G, chromosome 4 at 136,880,566 bp
  • A to G, chromosome 5 at 33,892,036 bp
  • A to G, chromosome 5 at 41,794,333 bp
  • A to G, chromosome 5 at 102,892,685 bp
  • G to A, chromosome 5 at 150,572,924 bp
  • G to T, chromosome 6 at 71,950,879 bp
  • G to A, chromosome 6 at 120,215,435 bp
  • T to A, chromosome 7 at 16,907,048 bp
  • T to A, chromosome 7 at 24,420,633 bp
  • A to G, chromosome 7 at 27,963,163 bp
  • A to G, chromosome 7 at 85,871,984 bp
  • G to C, chromosome 7 at 119,144,866 bp
  • A to T, chromosome 7 at 119,638,082 bp
  • A to T, chromosome 7 at 119,859,511 bp
  • A to G, chromosome 7 at 141,240,933 bp
  • A to C, chromosome 8 at 83,319,412 bp
  • C to A, chromosome 8 at 85,076,261 bp
  • A to G, chromosome 8 at 105,315,667 bp
  • T to A, chromosome 8 at 105,617,815 bp
  • A to G, chromosome 9 at 44,685,948 bp
  • T to C, chromosome 9 at 87,055,782 bp
  • T to A, chromosome 9 at 92,584,558 bp
  • T to C, chromosome 9 at 120,574,105 bp
  • T to A, chromosome 10 at 39,026,635 bp
  • A to G, chromosome 10 at 62,108,954 bp
  • T to A, chromosome 10 at 80,812,072 bp
  • C to T, chromosome 10 at 82,110,159 bp
  • A to G, chromosome 10 at 97,649,700 bp
  • T to A, chromosome 10 at 100,537,718 bp
  • A to G, chromosome 11 at 96,367,101 bp
  • A to T, chromosome 11 at 100,698,171 bp
  • A to T, chromosome 11 at 109,674,628 bp
  • G to A, chromosome 11 at 117,967,788 bp
  • T to C, chromosome 11 at 119,416,547 bp
  • G to A, chromosome 11 at 119,507,251 bp
  • G to A, chromosome 11 at 120,873,741 bp
  • A to G, chromosome 11 at 121,249,150 bp
  • A to G, chromosome 12 at 110,668,750 bp
  • G to T, chromosome 12 at 112,657,153 bp
  • A to G, chromosome 12 at 116,000,179 bp
  • A to G, chromosome 13 at 49,248,430 bp
  • A to T, chromosome 13 at 49,296,690 bp
  • T to C, chromosome 13 at 68,630,954 bp
  • T to C, chromosome 13 at 72,631,277 bp
  • A to T, chromosome 14 at 20,721,484 bp
  • T to G, chromosome 14 at 50,765,943 bp
  • T to A, chromosome 14 at 67,828,502 bp
  • G to T, chromosome 15 at 8,180,915 bp
  • G to T, chromosome 15 at 76,662,810 bp
  • T to A, chromosome 15 at 81,667,387 bp
  • T to C, chromosome 15 at 92,232,275 bp
  • T to A, chromosome 16 at 13,405,854 bp
  • T to C, chromosome 16 at 20,287,875 bp
  • A to G, chromosome 16 at 22,061,882 bp
  • G to A, chromosome 16 at 93,849,173 bp
  • T to A, chromosome 16 at 97,568,416 bp
  • A to T, chromosome 17 at 21,880,660 bp
  • G to A, chromosome 17 at 32,489,655 bp
  • A to G, chromosome 17 at 47,601,785 bp
  • A to G, chromosome 17 at 57,052,827 bp
  • T to C, chromosome 17 at 67,767,385 bp
  • T to A, chromosome 18 at 90,540,071 bp
  • G to A, chromosome 19 at 9,002,143 bp
  • A to G, chromosome 19 at 9,009,827 bp
  • T to C, chromosome 19 at 12,268,704 bp
  • A to G, chromosome 19 at 34,241,786 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7311 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045367-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.