Strain Name:
C57BL/6J-MtgxR7309Btlr/Mmmh
Stock Number:
045408-MU
Citation ID:
RRID:MMRRC_045408-MU
Other Names:
R7309 (G1)
Major Collection:

Strain Information

Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Comp
Name: cartilage oligomeric matrix protein
Synonyms: TSP5, thrombospondin-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Cop1
Name: COP1, E3 ubiquitin ligase
Synonyms: Cop1, Rfwd2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26374
Homologene: 115565
Tnks2
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms: 5430432P15Rik, Parp5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74493
Homologene: 11890
Dnm1l
Name: dynamin 1-like
Synonyms: Drp1, Dnmlp1, 6330417M19Rik, python
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 65114
Homologene: 6221
Anapc1
Name: anaphase promoting complex subunit 1
Synonyms: tsg24, 2610021O03Rik, Apc1, Mcpr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17222
Homologene: 7414
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20846
Homologene: 21428
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
Synonyms: Mlk3, 2610017K16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26403
VEGA: 19
HGNC: HGNC:6850
Homologene: 37618
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269608
Homologene: 10768
Med13
Name: mediator complex subunit 13
Synonyms: 1110067M05Rik, Trap240, Thrap1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Kcnj9
Name: potassium inwardly-rectifying channel, subfamily J, member 9
Synonyms: 1700085N21Rik, Girk3, Kir3.3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16524
HGNC: HGNC:6270
Homologene: 37989
4930522L14Rik
Name: RIKEN cDNA 4930522L14 gene
Synonyms: Gm42152
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041734
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: multiple PDZ domain protein, B930003D11Rik, MUPP1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Hnrnpdl
Name: heterogeneous nuclear ribonucleoprotein D-like
Synonyms: D5Ertd650e, hnRNP-DL, JKTBP, Hnrpdl, D5Wsu145e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50926
HGNC: HGNC:5037
Homologene: 75314
Slc25a27
Name: solute carrier family 25, member 27
Synonyms: 9430092A03Rik, Ucp4, 3632410G24Rik, D530043E16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74011
VEGA: 17
Homologene: 12523
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Fign
Name: fidgetin
Synonyms: Fgn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60344
Homologene: 5813
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Wdr95
Name: WD40 repeat domain 95
Synonyms: 4930434E21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381693
Homologene: 124480
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Miox
Name: myo-inositol oxygenase
Synonyms: Aldrl6, RSOR, C85427, 0610009I10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56727
Homologene: 9732
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 626359
Homologene: 56878
Slc35e1
Name: solute carrier family 35, member E1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270066
Homologene: 49075
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Mthfsd
Name: methenyltetrahydrofolate synthetase domain containing
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234814
Homologene: 11245
Wdr90
Name: WD repeat domain 90
Synonyms: 3230401M21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106618
Homologene: 27066
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11, Olfr935
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Or14c45
Name: olfactory receptor family 14 subfamily C member 45
Synonyms: Olfr297, MOR220-3, GA_x6K02T2NHDJ-9587747-9586815
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258611
Homologene: 115526
4932414N04Rik
Name: RIKEN cDNA 4932414N04 gene
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75721
Homologene: 138468
Kcna7
Name: potassium voltage-gated channel, shaker-related subfamily, member 7
Synonyms: Kv1.7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16495
HGNC: HGNC:6226
Homologene: 7791
Mettl24
Name: methyltransferase like 24
Synonyms: 9030224M15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327747
Homologene: 65335
Cox18
Name: cytochrome c oxidase assembly protein 18
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231430
Homologene: 14821
Lrrc14b
Name: leucine rich repeat containing 14B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432779
Homologene: 47758
Foxf2
Name: forkhead box F2
Synonyms: LUN, FREAC2, Fkh20
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14238
HGNC: HGNC:3810
Homologene: 1115
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Prr23a2
Name: proline rich 23A, member 2
Synonyms: Gm6406
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 623186
Homologene: 67036
Or4c3d
Name: olfactory receptor family 4 subfamily C member 3D
Synonyms: Olfr140, A16, GA_x6K02T2Q125-51484508-51483600, MOR235-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57272
Homologene: 41379
Csrp3
Name: cysteine and glycine-rich protein 3
Synonyms: MLP, CRP3, muscle LIM protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13009
HGNC: HGNC:2472
Homologene: 20742
Fam187a
Name: family with sequence similarity 187, member A
Synonyms: 4933439F11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66784
Homologene: 128440
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: dysadherin, EF-8, Oit2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Cldnd2
Name: claudin domain containing 2
Synonyms: 1700071E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74276
Homologene: 17559
Sh3bp5
Name: SH3-domain binding protein 5 (BTK-associated)
Synonyms: Sab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 24056
Homologene: 23450
Trav7-1
Name: T cell receptor alpha variable 7-1
Synonyms: Gm16452
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 671652
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,126,621 bp
  • A to G, chromosome 1 at 159,306,625 bp
  • A to G, chromosome 1 at 172,326,258 bp
  • A to T, chromosome 2 at 63,979,957 bp
  • A to T, chromosome 2 at 68,716,186 bp
  • A to G, chromosome 2 at 76,898,326 bp
  • T to A, chromosome 2 at 90,051,457 bp
  • A to G, chromosome 2 at 128,674,684 bp
  • A to T, chromosome 2 at 140,125,091 bp
  • A to T, chromosome 3 at 87,795,077 bp
  • A to T, chromosome 4 at 81,381,958 bp
  • C to A, chromosome 4 at 152,112,528 bp
  • T to C, chromosome 5 at 89,170,751 bp
  • T to C, chromosome 5 at 90,215,058 bp
  • A to T, chromosome 5 at 100,037,623 bp
  • A to C, chromosome 5 at 109,736,953 bp
  • A to T, chromosome 5 at 113,268,846 bp
  • A to G, chromosome 5 at 149,606,293 bp
  • A to T, chromosome 6 at 140,023,156 bp
  • T to C, chromosome 7 at 31,035,404 bp
  • A to G, chromosome 7 at 43,441,709 bp
  • T to G, chromosome 7 at 45,409,255 bp
  • A to G, chromosome 7 at 48,835,569 bp
  • T to A, chromosome 7 at 79,773,355 bp
  • T to A, chromosome 7 at 86,527,141 bp
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,911 bp
  • A to T, chromosome 8 at 70,373,678 bp
  • G to C, chromosome 8 at 72,492,514 bp
  • A to T, chromosome 8 at 85,274,967 bp
  • A to G, chromosome 8 at 94,474,042 bp
  • A to G, chromosome 8 at 109,648,261 bp
  • G to A, chromosome 8 at 121,108,331 bp
  • T to A, chromosome 9 at 38,995,280 bp
  • T to A, chromosome 9 at 98,856,974 bp
  • T to C, chromosome 10 at 40,810,500 bp
  • T to C, chromosome 11 at 82,956,703 bp
  • C to A, chromosome 11 at 86,291,062 bp
  • T to A, chromosome 11 at 102,886,006 bp
  • A to G, chromosome 13 at 31,626,513 bp
  • C to A, chromosome 13 at 74,363,202 bp
  • C to T, chromosome 14 at 31,378,289 bp
  • C to A, chromosome 14 at 52,655,064 bp
  • G to T, chromosome 15 at 89,336,049 bp
  • A to G, chromosome 16 at 16,321,646 bp
  • G to A, chromosome 16 at 49,096,465 bp
  • T to C, chromosome 17 at 25,860,702 bp
  • A to T, chromosome 17 at 30,875,014 bp
  • A to T, chromosome 17 at 43,664,192 bp
  • T to C, chromosome 19 at 5,690,458 bp
  • G to T, chromosome 19 at 36,852,536 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7309 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045408-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.