Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7338Btlr/Mmmh
Stock Number:
045428-MU
Citation ID:
RRID:MMRRC_045428-MU
Other Names:
R7338 (G1)
Major Collection:

Strain Information

Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Gjd2
Name: gap junction protein, delta 2
Synonyms: connexin36, Cx36, Gja9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14617
Homologene: 7734
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Med21
Name: mediator complex subunit 21
Synonyms: Srb7, 0610007L03Rik, D6Ertd782e, Surb7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108098
Homologene: 3148
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, Gpiap1, caprin-1, RNG105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 98,421,372 bp
  • G to A, chromosome 1 at 173,760,137 bp
  • C to A, chromosome 2 at 25,621,614 bp
  • T to A, chromosome 2 at 35,323,748 bp
  • A to T, chromosome 2 at 86,131,382 bp
  • A to G, chromosome 2 at 103,779,423 bp
  • C to T, chromosome 2 at 114,011,102 bp
  • A to G, chromosome 2 at 121,193,984 bp
  • G to A, chromosome 2 at 122,055,377 bp
  • T to C, chromosome 2 at 164,332,808 bp
  • T to A, chromosome 3 at 87,994,243 bp
  • A to T, chromosome 3 at 142,538,025 bp
  • G to T, chromosome 4 at 49,771,238 bp
  • T to A, chromosome 4 at 96,307,287 bp
  • A to G, chromosome 4 at 128,588,150 bp
  • A to G, chromosome 4 at 154,152,586 bp
  • A to G, chromosome 4 at 155,647,551 bp
  • T to A, chromosome 5 at 38,300,203 bp
  • T to A, chromosome 5 at 110,873,514 bp
  • G to A, chromosome 6 at 31,529,006 bp
  • C to A, chromosome 6 at 119,448,131 bp
  • T to A, chromosome 6 at 146,642,584 bp
  • A to G, chromosome 7 at 4,521,380 bp
  • A to T, chromosome 7 at 26,842,947 bp
  • A to G, chromosome 7 at 28,564,956 bp
  • A to T, chromosome 7 at 140,202,533 bp
  • G to A, chromosome 8 at 4,216,212 bp
  • T to G, chromosome 8 at 107,057,284 bp
  • T to C, chromosome 9 at 8,099,798 bp
  • A to G, chromosome 9 at 38,982,520 bp
  • A to G, chromosome 9 at 44,508,708 bp
  • A to G, chromosome 9 at 45,674,504 bp
  • G to A, chromosome 9 at 45,925,989 bp
  • A to G, chromosome 9 at 106,203,939 bp
  • G to A, chromosome 10 at 109,769,212 bp
  • A to T, chromosome 10 at 128,799,083 bp
  • T to C, chromosome 11 at 17,054,657 bp
  • C to T, chromosome 11 at 42,182,294 bp
  • C to T, chromosome 11 at 72,266,484 bp
  • T to C, chromosome 12 at 70,044,064 bp
  • C to T, chromosome 12 at 72,463,531 bp
  • G to A, chromosome 12 at 101,480,984 bp
  • G to T, chromosome 12 at 102,562,841 bp
  • A to T, chromosome 13 at 20,280,812 bp
  • A to C, chromosome 13 at 102,706,428 bp
  • T to C, chromosome 14 at 44,336,457 bp
  • C to T, chromosome 15 at 5,099,872 bp
  • A to G, chromosome 15 at 78,459,819 bp
  • T to C, chromosome 15 at 97,810,022 bp
  • C to A, chromosome 16 at 59,448,076 bp
  • T to C, chromosome 17 at 24,376,743 bp
  • T to A, chromosome 17 at 24,650,208 bp
  • T to C, chromosome 17 at 35,888,144 bp
  • T to C, chromosome 17 at 46,579,599 bp
  • T to C, chromosome 17 at 67,896,111 bp
  • T to G, chromosome 17 at 74,489,776 bp
  • T to A, chromosome 19 at 40,837,033 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7338 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045428-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.