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Strain Name:
C57BL/6J-MtgxR7338Btlr/Mmmh
Stock Number:
045428-MU
Citation ID:
RRID:MMRRC_045428-MU
Other Names:
R7338 (G1)
Major Collection:

Strain Information

Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Gjd2
Name: gap junction protein, delta 2
Synonyms: connexin36, Cx36, Gja9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14617
Homologene: 7734
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NMDAR-L, NR3A, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Cdk11b
Name: cyclin dependent kinase 11B
Synonyms: CDK11-p110, PITSLRE proteins, CDK11-p46, CDK11-p58, Cdc2l2, Cdc2l1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12537
Homologene: 22416
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Med21
Name: mediator complex subunit 21
Synonyms: Srb7, 0610007L03Rik, D6Ertd782e, Surb7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108098
Homologene: 3148
Caprin1
Name: cell cycle associated protein 1
Synonyms: MMGPIP137, Gpiap1, caprin-1, RNG105
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53872
HGNC: HGNC:6743
Homologene: 4310
Chek2
Name: checkpoint kinase 2
Synonyms: CHK2, Rad53
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50883
Homologene: 38289
Tmprss6
Name: transmembrane serine protease 6
Synonyms: matriptase-2, 1300008A22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71753
VEGA: 15
Homologene: 12408
Dhx16
Name: DEAH-box helicase 16
Synonyms: 2410006N22Rik, DBP2, Ddx16, DEAH (Asp-Glu-Ala-His) box polypeptide 16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Gabrr3
Name: gamma-aminobutyric acid type A receptor subunit rho 3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328699
VEGA: 16
Homologene: 26716
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239319
Homologene: 13067
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: C530005A01Rik, 6030465E24Rik, spastic paraplegia 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214585
Homologene: 41614
Ptk7
Name: PTK7 protein tyrosine kinase 7
Synonyms: 8430404F20Rik, mPTK7/CCK4, chz
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71461
VEGA: 17
HGNC: HGNC:9618
Homologene: 43672
Twf2
Name: twinfilin actin binding protein 2
Synonyms: A6-related, Twf2, Twinfilin-2, Ptk9l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23999
HGNC: HGNC:9621
Homologene: 5272
Pak4
Name: p21 (RAC1) activated kinase 4
Synonyms: 5730488L07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70584
Homologene: 4300
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268970
Homologene: 18264
Abca3
Name: ATP-binding cassette, sub-family A member 3
Synonyms: ABC-C, Abc3, 1810036E22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27410
HGNC: HGNC:33
Homologene: 37437
Nip7
Name: NIP7, nucleolar pre-rRNA processing protein
Synonyms: 1110017C15Rik, 6330509M23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66164
Homologene: 56743
Otop1
Name: otopetrin 1
Synonyms: A530025J20Rik, tlt
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21906
Homologene: 35244
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, POMFIL1, 4732483H20Rik, unc53H3, steerin 3, 9630020C08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Slc13a5
Name: solute carrier family 13 (sodium-dependent citrate transporter), member 5
Synonyms: Nact, NaC2/NaCT, mINDY, Indy
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237831
Homologene: 21941
Chga
Name: chromogranin A
Synonyms: ChrA
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12652
VEGA: 12
HGNC: HGNC:1929
Homologene: 976
Cyp2j11
Name: cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms: Cyp2j11-ps
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100066
HGNC: HGNC:2634
Homologene: 133819
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Cep126
Name: centrosomal protein 126
Synonyms: AK129341
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234915
VEGA: 9
Homologene: 28313
Bcl9l
Name: B cell CLL/lymphoma 9-like
Synonyms: DLNB11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80288
VEGA: 9
Homologene: 65615
Gbp7
Name: guanylate binding protein 7
Synonyms: 9830147J24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229900
Homologene: 138296
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: DD57, 2610044M17Rik, 5330425N03Rik, Wdr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 59002
Homologene: 9857
Nin
Name: ninein
Synonyms: 3110068G20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18080
Homologene: 40632
Lrrc9
Name: leucine rich repeat containing 9
Synonyms: 4930432K16Rik, 4921529O18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78257
Homologene: 12692
Mmp19
Name: matrix metallopeptidase 19
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 58223
VEGA: 10
HGNC: HGNC:7165
Homologene: 1820
Ccnj
Name: cyclin J
Synonyms: D430039C20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240665
Homologene: 10413
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Stom
Name: stomatin
Synonyms: stomatin, protein 7.2b, Epb7.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Elmo1
Name: engulfment and cell motility 1
Synonyms: CED-12, C230095H21Rik, 6330578D22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 140580
Homologene: 56685
Or6b13
Name: olfactory receptor family 6 subfamily B member 13
Synonyms: GA_x6K02T2PBJ9-42354580-42353624, MOR103-14P, Olfr524
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258055
Homologene: 79347
Prr36
Name: proline rich 36
Synonyms: BC068157
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73072
Homologene: 136398
Tubgcp4
Name: tubulin, gamma complex component 4
Synonyms: 4932441P04Rik, D2Ertd435e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51885
Homologene: 8690
Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Synonyms: GABAA alpha 1, Gabra-1, GABAAR alpha1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14394
HGNC: HGNC:4075
Homologene: 629
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Or5al5
Name: olfactory receptor family 5 subfamily AL member 5
Synonyms: MOR185-5, GA_x6K02T2Q125-47600809-47599850, MOR185-9P, MOR185-5, MOR185-5, Olfr1517, Olfr1039
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257950
Homologene: 79382
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13087
Homologene: 85917
Svs5
Name: seminal vesicle secretory protein 5
Synonyms: Svp-1, Svp5, Svp1, seminal vesicle protein F, SVS V
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20944
Homologene: 49199
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15951
Homologene: 115929
Or10d1c
Name: olfactory receptor family 10 subfamily D member 1C
Synonyms: GA_x6K02T2PVTD-32678895-32677963, MOR224-6, Olfr934
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258434
VEGA: 9
Homologene: 51730
Yipf4
Name: Yip1 domain family, member 4
Synonyms: 2310034L04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67864
VEGA: 17
Homologene: 32658
Tnni3
Name: troponin I, cardiac 3
Synonyms: Tn1, cardiac troponin I, cTnI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21954
Homologene: 309
Nherf2
Name: NHERF family PDZ scaffold protein 2
Synonyms: Nherf2, Octs2, Tka-1, Sip-1, E3karp, 1200011K07Rik, Sip1, 0610011L07Rik, 2010007A20Rik, Sryip1, Slc9a3r2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 65962
VEGA: 17
Homologene: 56962
Podxl
Name: podocalyxin-like
Synonyms: Pclp1, Ly102, PC, podocalyxin, Podxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27205
HGNC: HGNC:9171
Homologene: 137260
Cnrip1
Name: cannabinoid receptor interacting protein 1
Synonyms: 5330437A18Rik, 3110054C06Rik, 1500041B16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380686
Homologene: 9153
Tmem141
Name: transmembrane protein 141
Synonyms: 1110065P14Rik, D2Ertd217e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51875
Homologene: 75339
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 98,421,372 bp
  • G to A, chromosome 1 at 173,760,137 bp
  • C to A, chromosome 2 at 25,621,614 bp
  • T to A, chromosome 2 at 35,323,748 bp
  • A to T, chromosome 2 at 86,131,382 bp
  • A to G, chromosome 2 at 103,779,423 bp
  • C to T, chromosome 2 at 114,011,102 bp
  • A to G, chromosome 2 at 121,193,984 bp
  • G to A, chromosome 2 at 122,055,377 bp
  • T to C, chromosome 2 at 164,332,808 bp
  • T to A, chromosome 3 at 87,994,243 bp
  • A to T, chromosome 3 at 142,538,025 bp
  • G to T, chromosome 4 at 49,771,238 bp
  • T to A, chromosome 4 at 96,307,287 bp
  • A to G, chromosome 4 at 128,588,150 bp
  • A to G, chromosome 4 at 154,152,586 bp
  • A to G, chromosome 4 at 155,647,551 bp
  • T to A, chromosome 5 at 38,300,203 bp
  • T to A, chromosome 5 at 110,873,514 bp
  • G to A, chromosome 6 at 31,529,006 bp
  • C to A, chromosome 6 at 119,448,131 bp
  • T to A, chromosome 6 at 146,642,584 bp
  • A to G, chromosome 7 at 4,521,380 bp
  • A to T, chromosome 7 at 26,842,947 bp
  • A to G, chromosome 7 at 28,564,956 bp
  • A to T, chromosome 7 at 140,202,533 bp
  • G to A, chromosome 8 at 4,216,212 bp
  • T to G, chromosome 8 at 107,057,284 bp
  • T to C, chromosome 9 at 8,099,798 bp
  • A to G, chromosome 9 at 38,982,520 bp
  • A to G, chromosome 9 at 44,508,708 bp
  • A to G, chromosome 9 at 45,674,504 bp
  • G to A, chromosome 9 at 45,925,989 bp
  • A to G, chromosome 9 at 106,203,939 bp
  • G to A, chromosome 10 at 109,769,212 bp
  • A to T, chromosome 10 at 128,799,083 bp
  • T to C, chromosome 11 at 17,054,657 bp
  • C to T, chromosome 11 at 42,182,294 bp
  • C to T, chromosome 11 at 72,266,484 bp
  • T to C, chromosome 12 at 70,044,064 bp
  • C to T, chromosome 12 at 72,463,531 bp
  • G to A, chromosome 12 at 101,480,984 bp
  • G to T, chromosome 12 at 102,562,841 bp
  • A to T, chromosome 13 at 20,280,812 bp
  • A to C, chromosome 13 at 102,706,428 bp
  • T to C, chromosome 14 at 44,336,457 bp
  • C to T, chromosome 15 at 5,099,872 bp
  • A to G, chromosome 15 at 78,459,819 bp
  • T to C, chromosome 15 at 97,810,022 bp
  • C to A, chromosome 16 at 59,448,076 bp
  • T to C, chromosome 17 at 24,376,743 bp
  • T to A, chromosome 17 at 24,650,208 bp
  • T to C, chromosome 17 at 35,888,144 bp
  • T to C, chromosome 17 at 46,579,599 bp
  • T to C, chromosome 17 at 67,896,111 bp
  • T to G, chromosome 17 at 74,489,776 bp
  • T to A, chromosome 19 at 40,837,033 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7338 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045428-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.