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Strain Name:
C57BL/6J-MtgxR7341Btlr/Mmmh
Stock Number:
045431-MU
Citation ID:
RRID:MMRRC_045431-MU
Other Names:
R7341 (G1)
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77569
Homologene: 18953
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Chd1
Name: chromodomain helicase DNA binding protein 1
Synonyms: 4930525N21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12648
HGNC: HGNC:1915
Homologene: 68174
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Baz1b
Name: bromodomain adjacent to zinc finger domain, 1B
Synonyms: Wbscr9, WSTF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22385
HGNC: HGNC:961
Homologene: 22651
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 111,861,573 bp
  • A to G, chromosome 1 at 153,793,845 bp
  • C to A, chromosome 1 at 166,676,546 bp
  • A to T, chromosome 2 at 26,369,261 bp
  • T to A, chromosome 2 at 33,034,129 bp
  • C to T, chromosome 2 at 69,299,867 bp
  • T to A, chromosome 2 at 70,476,697 bp
  • T to C, chromosome 2 at 84,862,934 bp
  • C to A, chromosome 2 at 118,636,786 bp
  • C to G, chromosome 2 at 164,827,662 bp
  • C to T, chromosome 3 at 53,654,495 bp
  • T to A, chromosome 3 at 59,042,403 bp
  • T to C, chromosome 3 at 64,105,456 bp
  • T to A, chromosome 3 at 76,482,397 bp
  • T to A, chromosome 3 at 79,600,297 bp
  • T to A, chromosome 3 at 88,981,759 bp
  • T to A, chromosome 4 at 19,586,837 bp
  • T to C, chromosome 4 at 19,887,330 bp
  • A to G, chromosome 4 at 45,898,644 bp
  • A to T, chromosome 4 at 58,809,415 bp
  • T to A, chromosome 4 at 106,735,510 bp
  • T to A, chromosome 4 at 111,768,738 bp
  • A to T, chromosome 4 at 123,715,951 bp
  • T to G, chromosome 4 at 131,843,675 bp
  • A to G, chromosome 4 at 149,343,001 bp
  • C to A, chromosome 5 at 14,675,836 bp
  • T to A, chromosome 5 at 24,595,437 bp
  • T to A, chromosome 5 at 30,364,468 bp
  • T to C, chromosome 5 at 41,788,857 bp
  • T to C, chromosome 5 at 64,953,629 bp
  • C to T, chromosome 5 at 67,034,202 bp
  • T to C, chromosome 5 at 105,607,267 bp
  • T to A, chromosome 5 at 109,086,247 bp
  • C to T, chromosome 5 at 109,091,945 bp
  • T to C, chromosome 5 at 123,864,478 bp
  • T to A, chromosome 5 at 135,223,116 bp
  • T to C, chromosome 5 at 143,176,072 bp
  • A to G, chromosome 6 at 14,718,750 bp
  • T to C, chromosome 6 at 30,494,795 bp
  • A to T, chromosome 6 at 34,891,460 bp
  • G to A, chromosome 6 at 70,960,878 bp
  • T to A, chromosome 6 at 124,577,452 bp
  • G to T, chromosome 6 at 134,450,818 bp
  • C to T, chromosome 7 at 16,280,627 bp
  • G to A, chromosome 7 at 35,429,928 bp
  • T to A, chromosome 7 at 48,552,896 bp
  • T to A, chromosome 7 at 82,556,874 bp
  • T to C, chromosome 8 at 11,398,678 bp
  • T to A, chromosome 8 at 24,687,980 bp
  • A to T, chromosome 8 at 45,321,750 bp
  • T to C, chromosome 8 at 124,896,581 bp
  • G to T, chromosome 9 at 57,700,824 bp
  • A to T, chromosome 9 at 65,688,901 bp
  • C to T, chromosome 9 at 106,885,047 bp
  • T to A, chromosome 9 at 119,937,534 bp
  • A to G, chromosome 10 at 58,485,797 bp
  • A to T, chromosome 10 at 60,750,658 bp
  • A to G, chromosome 10 at 79,816,863 bp
  • G to A, chromosome 10 at 85,928,665 bp
  • C to T, chromosome 11 at 31,918,807 bp
  • A to T, chromosome 11 at 58,542,707 bp
  • C to A, chromosome 11 at 76,846,953 bp
  • A to G, chromosome 11 at 82,898,777 bp
  • A to G, chromosome 11 at 87,766,379 bp
  • G to T, chromosome 11 at 96,299,569 bp
  • T to C, chromosome 12 at 102,743,179 bp
  • G to T, chromosome 13 at 23,846,884 bp
  • T to G, chromosome 13 at 24,832,076 bp
  • A to G, chromosome 13 at 46,826,745 bp
  • T to A, chromosome 13 at 54,719,492 bp
  • A to G, chromosome 13 at 74,372,348 bp
  • G to T, chromosome 13 at 113,318,172 bp
  • A to G, chromosome 14 at 101,885,512 bp
  • A to C, chromosome 15 at 7,924,244 bp
  • A to G, chromosome 15 at 9,165,819 bp
  • A to T, chromosome 15 at 76,714,511 bp
  • A to G, chromosome 15 at 91,242,670 bp
  • T to C, chromosome 16 at 17,150,898 bp
  • C to T, chromosome 16 at 38,712,514 bp
  • T to A, chromosome 16 at 59,315,149 bp
  • CACTTAC to CAC, chromosome 16 at 90,772,573 bp
  • T to C, chromosome 17 at 15,770,237 bp
  • A to G, chromosome 17 at 32,486,954 bp
  • C to A, chromosome 17 at 35,526,713 bp
  • T to A, chromosome 17 at 74,612,074 bp
  • A to T, chromosome 18 at 20,852,647 bp
  • G to A, chromosome 19 at 11,590,073 bp
  • T to A, chromosome 19 at 29,646,254 bp
  • T to G, chromosome 19 at 45,049,262 bp
  • G to A, chromosome X at 74,306,855 bp
  • A to T, chromosome Y at 1,315,759 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7341 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045431-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.