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Strain Name:
C57BL/6J-MtgxR7343Btlr/Mmmh
Stock Number:
045433-MU
Citation ID:
RRID:MMRRC_045433-MU
Other Names:
R7343 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Rps19
Name: ribosomal protein S19
Synonyms: Dsk3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20085
Homologene: 37416
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Dido1
Name: death inducer-obliterator 1
Synonyms: DIO-1, 6720461J16Rik, D130048F08Rik, Datf1, dido, C130092D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23856
HGNC: HGNC:2680
Homologene: 34139
Thrap3
Name: thyroid hormone receptor associated protein 3
Synonyms: 9330151F09Rik, Trap150, B230333E16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230753
Homologene: 31289
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 9,968,857 bp
  • C to T, chromosome 1 at 111,861,573 bp
  • A to T, chromosome 1 at 117,986,112 bp
  • T to A, chromosome 1 at 119,995,098 bp
  • G to A, chromosome 1 at 120,022,225 bp
  • C to A, chromosome 1 at 150,393,494 bp
  • A to T, chromosome 1 at 169,982,078 bp
  • A to T, chromosome 1 at 174,042,853 bp
  • A to T, chromosome 1 at 174,223,349 bp
  • A to G, chromosome 1 at 188,415,746 bp
  • T to G, chromosome 2 at 13,010,778 bp
  • G to A, chromosome 2 at 14,452,000 bp
  • C to T, chromosome 2 at 50,291,445 bp
  • G to A, chromosome 2 at 62,358,901 bp
  • C to T, chromosome 2 at 69,299,867 bp
  • A to T, chromosome 2 at 79,428,760 bp
  • A to T, chromosome 2 at 82,979,367 bp
  • T to G, chromosome 2 at 88,831,846 bp
  • T to G, chromosome 2 at 166,077,616 bp
  • A to T, chromosome 2 at 180,675,121 bp
  • C to A, chromosome 3 at 89,091,750 bp
  • T to A, chromosome 3 at 106,132,015 bp
  • G to A, chromosome 4 at 35,709,450 bp
  • T to G, chromosome 4 at 82,994,122 bp
  • A to T, chromosome 4 at 126,178,430 bp
  • A to C, chromosome 4 at 129,632,160 bp
  • T to C, chromosome 4 at 139,413,438 bp
  • A to G, chromosome 5 at 4,046,364 bp
  • T to A, chromosome 5 at 98,184,516 bp
  • A to T, chromosome 5 at 104,968,234 bp
  • G to C, chromosome 5 at 114,636,459 bp
  • G to A, chromosome 5 at 120,493,149 bp
  • A to G, chromosome 5 at 143,877,671 bp
  • A to T, chromosome 5 at 143,998,182 bp
  • A to G, chromosome 6 at 83,154,939 bp
  • A to C, chromosome 6 at 83,162,371 bp
  • G to A, chromosome 6 at 113,536,939 bp
  • A to T, chromosome 6 at 136,702,748 bp
  • T to C, chromosome 7 at 10,050,350 bp
  • T to C, chromosome 7 at 24,885,146 bp
  • T to A, chromosome 7 at 39,408,756 bp
  • T to A, chromosome 7 at 48,867,965 bp
  • A to T, chromosome 7 at 68,237,721 bp
  • A to T, chromosome 7 at 118,724,575 bp
  • A to T, chromosome 7 at 139,876,142 bp
  • A to T, chromosome 7 at 141,322,958 bp
  • A to T, chromosome 8 at 72,711,782 bp
  • A to T, chromosome 8 at 83,295,252 bp
  • A to G, chromosome 8 at 120,145,588 bp
  • C to T, chromosome 9 at 20,793,946 bp
  • T to C, chromosome 9 at 42,337,332 bp
  • A to G, chromosome 9 at 45,752,916 bp
  • A to T, chromosome 9 at 57,760,956 bp
  • G to A, chromosome 9 at 108,209,093 bp
  • C to A, chromosome 10 at 25,289,669 bp
  • G to T, chromosome 10 at 80,584,157 bp
  • T to C, chromosome 10 at 86,692,183 bp
  • T to A, chromosome 10 at 109,903,758 bp
  • C to G, chromosome 10 at 129,409,983 bp
  • C to T, chromosome 11 at 3,493,022 bp
  • A to G, chromosome 11 at 6,620,065 bp
  • A to G, chromosome 11 at 23,488,868 bp
  • C to T, chromosome 11 at 45,883,763 bp
  • A to G, chromosome 11 at 49,564,502 bp
  • A to G, chromosome 11 at 53,986,538 bp
  • A to T, chromosome 11 at 58,311,505 bp
  • A to G, chromosome 11 at 68,557,048 bp
  • A to T, chromosome 11 at 69,132,743 bp
  • G to T, chromosome 11 at 74,044,900 bp
  • G to T, chromosome 11 at 76,249,900 bp
  • A to G, chromosome 11 at 78,497,257 bp
  • A to T, chromosome 11 at 80,019,703 bp
  • A to T, chromosome 11 at 83,421,990 bp
  • A to G, chromosome 11 at 108,395,848 bp
  • T to A, chromosome 12 at 56,695,862 bp
  • A to T, chromosome 12 at 101,760,816 bp
  • A to T, chromosome 13 at 4,137,237 bp
  • C to A, chromosome 13 at 24,701,444 bp
  • A to G, chromosome 13 at 55,159,155 bp
  • T to C, chromosome 14 at 30,123,057 bp
  • T to A, chromosome 15 at 37,944,573 bp
  • T to C, chromosome 15 at 79,691,042 bp
  • C to A, chromosome 16 at 5,247,435 bp
  • T to C, chromosome 16 at 29,321,749 bp
  • G to T, chromosome 16 at 59,960,430 bp
  • A to G, chromosome 16 at 70,361,015 bp
  • A to C, chromosome 17 at 22,200,068 bp
  • T to C, chromosome 17 at 29,705,543 bp
  • T to C, chromosome 17 at 31,619,139 bp
  • A to G, chromosome 17 at 32,797,513 bp
  • T to C, chromosome 18 at 3,426,873 bp
  • T to C, chromosome 18 at 36,930,649 bp
  • G to A, chromosome 18 at 67,135,525 bp
  • A to T, chromosome 19 at 38,795,024 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7343 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045433-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.