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Strain Name:
C57BL/6J-MtgxR7350Btlr/Mmmh
Stock Number:
045436-MU
Citation ID:
RRID:MMRRC_045436-MU
Other Names:
R7350 (G1)
Major Collection:

Strain Information

Alg10
Name: ALG10 alpha-1,2-glucosyltransferase
Synonyms: Deaf1, LOC380959, nse5, Alg10b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380959
VEGA: 15
Homologene: 6030
Kcnj10
Name: potassium inwardly-rectifying channel, subfamily J, member 10
Synonyms: Kir1.2, BIRK-1, BIR10, Kir4.1, Kir4.1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16513
HGNC: HGNC:6256
Homologene: 1689
Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: R75019, VGAT, Viaat
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22348
Homologene: 56451
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 116871
Homologene: 14282
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Eif4a2
Name: eukaryotic translation initiation factor 4A2
Synonyms: Eif4, 4833432N07Rik, BM-010, Ddx2b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13682
HGNC: HGNC:3284
Homologene: 1487
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 74,948,333 bp
  • T to C, chromosome 1 at 131,178,536 bp
  • C to T, chromosome 1 at 163,076,289 bp
  • G to T, chromosome 1 at 164,192,708 bp
  • A to G, chromosome 1 at 172,369,260 bp
  • A to G, chromosome 1 at 195,155,286 bp
  • T to C, chromosome 2 at 34,948,233 bp
  • T to A, chromosome 2 at 36,996,861 bp
  • G to T, chromosome 2 at 60,458,379 bp
  • A to G, chromosome 2 at 85,674,845 bp
  • T to C, chromosome 2 at 87,896,409 bp
  • A to T, chromosome 2 at 88,093,198 bp
  • G to T, chromosome 2 at 102,834,262 bp
  • T to C, chromosome 2 at 104,608,956 bp
  • A to G, chromosome 2 at 158,614,406 bp
  • A to G, chromosome 2 at 180,971,076 bp
  • T to A, chromosome 2 at 181,380,435 bp
  • T to C, chromosome 3 at 86,351,902 bp
  • T to A, chromosome 3 at 116,114,562 bp
  • A to T, chromosome 4 at 34,806,839 bp
  • C to T, chromosome 4 at 63,431,959 bp
  • A to T, chromosome 4 at 100,425,943 bp
  • C to T, chromosome 4 at 141,479,385 bp
  • T to G, chromosome 5 at 30,621,966 bp
  • T to A, chromosome 5 at 31,137,161 bp
  • T to A, chromosome 5 at 103,847,092 bp
  • A to T, chromosome 5 at 111,226,037 bp
  • T to C, chromosome 6 at 51,475,375 bp
  • A to T, chromosome 6 at 55,301,025 bp
  • C to T, chromosome 6 at 60,976,336 bp
  • A to G, chromosome 6 at 82,981,949 bp
  • A to G, chromosome 6 at 116,540,534 bp
  • A to G, chromosome 7 at 26,836,783 bp
  • C to G, chromosome 7 at 65,658,924 bp
  • T to C, chromosome 7 at 132,874,849 bp
  • A to G, chromosome 7 at 139,226,106 bp
  • A to T, chromosome 7 at 140,921,278 bp
  • G to T, chromosome 8 at 4,235,626 bp
  • T to C, chromosome 8 at 40,348,958 bp
  • A to T, chromosome 8 at 66,468,399 bp
  • A to G, chromosome 8 at 122,785,946 bp
  • G to C, chromosome 8 at 125,165,102 bp
  • T to A, chromosome 9 at 84,010,326 bp
  • T to C, chromosome 9 at 96,544,355 bp
  • T to C, chromosome 9 at 99,582,549 bp
  • T to C, chromosome 9 at 123,427,480 bp
  • T to C, chromosome 10 at 41,251,756 bp
  • A to G, chromosome 10 at 59,350,418 bp
  • A to T, chromosome 10 at 59,951,495 bp
  • A to T, chromosome 10 at 60,410,910 bp
  • A to T, chromosome 10 at 79,268,385 bp
  • C to A, chromosome 10 at 79,540,298 bp
  • C to T, chromosome 10 at 79,903,197 bp
  • T to C, chromosome 11 at 66,080,578 bp
  • A to G, chromosome 11 at 69,741,060 bp
  • G to C, chromosome 11 at 77,137,561 bp
  • T to A, chromosome 11 at 78,057,976 bp
  • A to T, chromosome 11 at 87,600,650 bp
  • C to A, chromosome 11 at 100,205,100 bp
  • T to A, chromosome 12 at 28,563,409 bp
  • A to G, chromosome 12 at 105,218,675 bp
  • A to G, chromosome 13 at 56,176,307 bp
  • A to G, chromosome 13 at 114,837,202 bp
  • C to A, chromosome 14 at 43,230,601 bp
  • T to C, chromosome 14 at 66,309,205 bp
  • T to C, chromosome 14 at 70,546,547 bp
  • T to A, chromosome 15 at 28,235,819 bp
  • G to A, chromosome 15 at 79,028,903 bp
  • T to C, chromosome 15 at 83,010,439 bp
  • A to T, chromosome 15 at 90,227,450 bp
  • A to G, chromosome 16 at 23,113,262 bp
  • A to G, chromosome 17 at 5,726,876 bp
  • A to T, chromosome 17 at 25,946,711 bp
  • T to C, chromosome 17 at 32,316,575 bp
  • C to A, chromosome 17 at 33,777,110 bp
  • G to A, chromosome 17 at 43,428,444 bp
  • T to A, chromosome 17 at 83,708,441 bp
  • T to C, chromosome 19 at 4,142,964 bp
  • C to A, chromosome 19 at 10,940,955 bp
  • G to A, chromosome 19 at 11,590,073 bp
  • T to C, chromosome 19 at 43,901,505 bp
  • T to A, chromosome 19 at 59,937,421 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7350 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045436-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.