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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7355Btlr/Mmmh
Stock Number:
045441-MU
Citation ID:
RRID:MMRRC_045441-MU
Other Names:
R7355 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099

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Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067

Additional Resources
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Gene Ontology
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ClinGen
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726

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IMPC
Google
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Gene Ontology
BioGPS
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Mouse Mine
KOMP Phenotyping
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ClinGen
Gon4l
Name: gon-4 like
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002

Additional Resources
IMPC
Google
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Gene Ontology
BioGPS
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Mouse Mine
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Monarch
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Phf14
Name: PHD finger protein 14
Synonyms: 1110001C23Rik, 4932409F11Rik, 5730446A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75725
Homologene: 8775

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
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Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 84,814,883 bp
  • A to T, chromosome 1 at 140,136,815 bp
  • A to T, chromosome 1 at 158,664,276 bp
  • C to T, chromosome 2 at 85,753,679 bp
  • T to C, chromosome 2 at 87,309,410 bp
  • G to A, chromosome 2 at 120,181,501 bp
  • G to T, chromosome 2 at 129,037,229 bp
  • A to T, chromosome 2 at 131,080,451 bp
  • A to T, chromosome 2 at 158,200,224 bp
  • A to G, chromosome 2 at 163,013,067 bp
  • A to T, chromosome 3 at 10,334,315 bp
  • T to A, chromosome 3 at 88,863,520 bp
  • C to A, chromosome 3 at 103,736,079 bp
  • T to C, chromosome 3 at 109,102,769 bp
  • A to G, chromosome 4 at 8,752,196 bp
  • T to A, chromosome 4 at 43,237,754 bp
  • T to C, chromosome 4 at 59,076,155 bp
  • A to G, chromosome 4 at 155,357,496 bp
  • C to T, chromosome 5 at 44,177,117 bp
  • A to G, chromosome 5 at 77,268,028 bp
  • G to T, chromosome 5 at 121,630,717 bp
  • A to T, chromosome 5 at 130,414,891 bp
  • C to G, chromosome 5 at 134,216,649 bp
  • A to G, chromosome 6 at 12,081,007 bp
  • C to A, chromosome 6 at 113,338,346 bp
  • T to A, chromosome 6 at 116,582,955 bp
  • C to T, chromosome 7 at 3,323,509 bp
  • A to G, chromosome 7 at 17,747,387 bp
  • T to C, chromosome 7 at 25,774,106 bp
  • T to C, chromosome 7 at 67,075,304 bp
  • C to T, chromosome 7 at 126,387,611 bp
  • A to T, chromosome 7 at 130,821,443 bp
  • C to A, chromosome 8 at 35,807,072 bp
  • C to T, chromosome 8 at 70,135,307 bp
  • C to T, chromosome 8 at 84,978,384 bp
  • A to T, chromosome 9 at 42,367,142 bp
  • A to G, chromosome 9 at 45,909,374 bp
  • C to A, chromosome 9 at 87,253,955 bp
  • T to A, chromosome 10 at 52,166,079 bp
  • A to G, chromosome 10 at 61,174,320 bp
  • A to G, chromosome 10 at 81,075,631 bp
  • T to A, chromosome 10 at 123,009,516 bp
  • A to T, chromosome 11 at 34,823,364 bp
  • T to A, chromosome 11 at 55,256,551 bp
  • T to A, chromosome 11 at 85,912,009 bp
  • C to T, chromosome 11 at 100,752,443 bp
  • T to A, chromosome 12 at 8,713,906 bp
  • A to C, chromosome 12 at 51,791,298 bp
  • A to T, chromosome 12 at 79,240,054 bp
  • A to T, chromosome 12 at 102,472,235 bp
  • A to T, chromosome 12 at 103,604,582 bp
  • A to T, chromosome 12 at 111,825,051 bp
  • T to C, chromosome 12 at 116,858,951 bp
  • T to C, chromosome 13 at 59,821,802 bp
  • T to C, chromosome 13 at 64,771,962 bp
  • A to G, chromosome 13 at 77,091,303 bp
  • C to A, chromosome 14 at 31,545,109 bp
  • T to C, chromosome 14 at 60,045,004 bp
  • AT to ATT, chromosome 14 at 103,702,576 bp
  • T to C, chromosome 15 at 75,047,407 bp
  • G to A, chromosome 15 at 102,147,940 bp
  • C to T, chromosome 16 at 33,266,866 bp
  • T to C, chromosome 16 at 46,041,292 bp
  • T to G, chromosome 17 at 15,545,235 bp
  • G to A, chromosome 17 at 24,267,647 bp
  • A to G, chromosome 17 at 37,672,410 bp
  • T to A, chromosome 17 at 46,250,640 bp
  • A to T, chromosome 17 at 55,866,287 bp
  • A to G, chromosome 18 at 9,280,860 bp
  • G to A, chromosome 18 at 75,610,685 bp
  • C to T, chromosome 19 at 34,619,661 bp
  • T to C, chromosome 19 at 43,901,741 bp
  • T to C, chromosome 19 at 46,065,346 bp
  • T to A, chromosome 19 at 56,547,135 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7355 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045441-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.