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Strain Name:
C57BL/6J-MtgxR7380Btlr/Mmmh
Stock Number:
045462-MU
Citation ID:
RRID:MMRRC_045462-MU
Other Names:
R7380 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Sema7a
Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
Synonyms: Semaphorin K1, CDw108, Semal, 2900057C09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20361
VEGA: 9
Homologene: 2678
Ptch2
Name: patched 2
Synonyms: ptc2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19207
HGNC: HGNC:9586
Homologene: 37842
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67804
VEGA: 18
Homologene: 2332
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 32,333,604 bp
  • T to A, chromosome 1 at 60,244,810 bp
  • A to G, chromosome 1 at 91,152,216 bp
  • T to C, chromosome 1 at 127,937,990 bp
  • C to A, chromosome 1 at 135,962,008 bp
  • T to G, chromosome 1 at 155,232,483 bp
  • T to C, chromosome 1 at 167,692,040 bp
  • A to G, chromosome 1 at 172,216,849 bp
  • A to T, chromosome 2 at 57,340,159 bp
  • A to T, chromosome 2 at 91,190,195 bp
  • T to C, chromosome 2 at 112,640,157 bp
  • T to A, chromosome 3 at 28,920,472 bp
  • T to A, chromosome 3 at 36,025,921 bp
  • T to G, chromosome 3 at 51,459,847 bp
  • C to G, chromosome 3 at 86,325,074 bp
  • T to A, chromosome 4 at 43,641,254 bp
  • T to C, chromosome 4 at 87,791,943 bp
  • T to A, chromosome 4 at 88,274,198 bp
  • T to C, chromosome 4 at 105,794,396 bp
  • C to A, chromosome 4 at 117,114,646 bp
  • T to C, chromosome 4 at 117,131,153 bp
  • C to T, chromosome 4 at 132,786,217 bp
  • G to A, chromosome 4 at 140,917,686 bp
  • G to T, chromosome 5 at 3,722,576 bp
  • A to T, chromosome 5 at 86,917,719 bp
  • A to G, chromosome 5 at 105,607,835 bp
  • C to A, chromosome 5 at 115,110,998 bp
  • T to C, chromosome 6 at 13,078,168 bp
  • T to C, chromosome 6 at 49,108,999 bp
  • T to G, chromosome 6 at 87,893,842 bp
  • T to C, chromosome 6 at 116,540,933 bp
  • C to A, chromosome 6 at 120,405,918 bp
  • T to C, chromosome 6 at 124,456,989 bp
  • T to C, chromosome 6 at 148,180,995 bp
  • C to T, chromosome 7 at 16,134,353 bp
  • A to T, chromosome 7 at 44,661,042 bp
  • A to G, chromosome 7 at 64,411,909 bp
  • GGCGG to GGCGGTGGCCGCGG, chromosome 7 at 97,579,915 bp
  • G to T, chromosome 7 at 105,758,628 bp
  • A to T, chromosome 7 at 126,764,795 bp
  • A to T, chromosome 7 at 127,476,442 bp
  • A to T, chromosome 7 at 140,224,877 bp
  • T to C, chromosome 8 at 116,973,637 bp
  • T to A, chromosome 8 at 119,445,431 bp
  • T to C, chromosome 9 at 37,418,556 bp
  • T to A, chromosome 9 at 53,240,486 bp
  • T to C, chromosome 9 at 57,961,564 bp
  • A to G, chromosome 9 at 64,948,533 bp
  • A to G, chromosome 9 at 66,747,663 bp
  • G to A, chromosome 9 at 103,279,481 bp
  • T to A, chromosome 10 at 51,590,476 bp
  • A to G, chromosome 10 at 59,350,451 bp
  • C to A, chromosome 10 at 93,047,978 bp
  • A to T, chromosome 10 at 129,526,661 bp
  • T to A, chromosome 11 at 21,711,585 bp
  • T to C, chromosome 11 at 53,695,396 bp
  • T to C, chromosome 11 at 59,056,914 bp
  • T to C, chromosome 11 at 70,219,279 bp
  • T to A, chromosome 11 at 73,928,187 bp
  • G to A, chromosome 11 at 76,802,325 bp
  • C to T, chromosome 11 at 79,546,276 bp
  • C to T, chromosome 11 at 83,003,740 bp
  • T to C, chromosome 11 at 115,796,145 bp
  • A to T, chromosome 12 at 58,213,280 bp
  • A to G, chromosome 12 at 87,077,948 bp
  • A to C, chromosome 13 at 55,542,799 bp
  • G to A, chromosome 14 at 70,617,328 bp
  • A to T, chromosome 14 at 75,256,009 bp
  • A to T, chromosome 15 at 25,779,620 bp
  • T to A, chromosome 15 at 28,370,378 bp
  • T to A, chromosome 15 at 47,586,965 bp
  • G to T, chromosome 15 at 97,766,791 bp
  • A to T, chromosome 16 at 20,397,034 bp
  • A to T, chromosome 16 at 32,755,366 bp
  • A to T, chromosome 16 at 56,034,256 bp
  • A to G, chromosome 16 at 59,304,028 bp
  • T to A, chromosome 17 at 18,136,576 bp
  • T to A, chromosome 17 at 24,581,642 bp
  • C to A, chromosome 17 at 33,958,309 bp
  • T to C, chromosome 17 at 34,021,720 bp
  • T to A, chromosome 17 at 55,898,551 bp
  • T to C, chromosome 18 at 53,194,568 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7380 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045462-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.