Strain Name:
C57BL/6J-MtgxR7446Btlr/Mmmh
Stock Number:
045522-MU
Citation ID:
RRID:MMRRC_045522-MU
Other Names:
R7446 (G1)
Major Collection:

Strain Information

Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: 1110001J02Rik, p110beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Gng12
Name: guanine nucleotide binding protein (G protein), gamma 12
Synonyms: 2010305F15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14701
Homologene: 32427
Adgrg1
Name: adhesion G protein-coupled receptor G1
Synonyms: Gpr56, Cyt28
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14766
HGNC: HGNC:4512
Homologene: 4156
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: 9130020K17Rik, D2Bwg1005e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku80, Ku86
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Mynn
Name: myoneurin
Synonyms: 2810011C24Rik, SBBIZ1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80732
Homologene: 10253
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: D030046N04Rik, 5430437K10Rik, BRIT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Erf
Name: Ets2 repressor factor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13875
HGNC: HGNC:3444
Homologene: 68516
Scaf4
Name: SR-related CTD-associated factor 4
Synonyms: Srsf15, Sfrs15, Sra4
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224432
VEGA: 16
Homologene: 16227
Zfp277
Name: zinc finger protein 277
Synonyms: NIRF4, 2410017E24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 246196
VEGA: 12
Homologene: 11087
Oas1d
Name: 2'-5' oligoadenylate synthetase 1D
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100535
HGNC: HGNC:8086
Homologene: 110815
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: DHC1b, DHC2, b2b414Clo, Dnchc2, 4432416O06Rik, D330044F14Rik, D030010H02Rik, m152Asp, m407Asp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Def8
Name: differentially expressed in FDCP 8
Synonyms: D8Ertd713e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23854
Homologene: 14279
Cul4a
Name: cullin 4A
Synonyms: 2810470J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 99375
HGNC: HGNC:2554
Homologene: 81724
Srsf6
Name: serine and arginine-rich splicing factor 6
Synonyms: Sfrs6, 1210001E11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67996
Homologene: 110783
Dennd1a
Name: DENN domain containing 1A
Synonyms: 6030446I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227801
Homologene: 17141
Nbas
Name: neuroblastoma amplified sequence
Synonyms: 4933425L03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71169
VEGA: 12
Homologene: 41073
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Hephl1
Name: hephaestin-like 1
Synonyms: thd, zyklopen, cw, Zp, LOC244698
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Prss46
Name: serine protease 46
Synonyms: 1700112C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74306
Homologene: 77706
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: 2410089E03Rik, Jbts17, b2b012Clo, Hug
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320683
Homologene: 65318
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216393
Homologene: 87610
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: MINK, Map4k6, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57775
Homologene: 49641
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Ralgds
Name: ral guanine nucleotide dissociation stimulator
Synonyms: Rgds, RalGDS, Gnds
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19730
HGNC: HGNC:9842
Homologene: 4562
Speer2
Name: spermatogenesis associated glutamate (E)-rich protein 2
Synonyms: SPEER-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224318
Homologene: 69402
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
4930407I10Rik
Name: RIKEN cDNA 4930407I10 gene
Synonyms: LOC328573
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328573
VEGA: 15
Homologene: 130065
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223658
Homologene: 44882
Tspan15
Name: tetraspanin 15
Synonyms: Tm4sf15, 2700063A19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70423
VEGA: 10
Homologene: 22716
Or10ak9
Name: olfactory receptor family 10 subfamily AK member 9
Synonyms: MOR259-3P, Olfr1331, GA_x6K02T2QD9B-18670866-18669913
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258159
Homologene: 134082
Pygl
Name: liver glycogen phosphorylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110095
HGNC: HGNC:9725
Homologene: 84371
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: Semag, SemG, SemG
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Ctbs
Name: chitobiase
Synonyms: 2210401K11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74245
HGNC: HGNC:2496
Homologene: 3231
C2
Name: complement C2
Synonyms: classical-complement pathway C3/C5 convertase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12263
HGNC: HGNC:1248
Homologene: 45
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Dcaf7
Name: DDB1 and CUL4 associated factor 7
Synonyms: Wdr68, 1700012F10Rik, 2610037L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71833
Homologene: 55930
Spock1
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
Synonyms: Ticn1, testican 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20745
Homologene: 80193
Slc24a3
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms: NCKX3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94249
Homologene: 41390
Guk1
Name: guanylate kinase 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14923
HGNC: HGNC:4693
Homologene: 665
Vmn1r181
Name: vomeronasal 1 receptor 181
Synonyms: V1rd20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404289
Homologene: 104166
Krt16
Name: keratin 16
Synonyms: Krt1-16, K16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16666
HGNC: HGNC:6423
Homologene: 21145
Cdk15
Name: cyclin dependent kinase 15
Synonyms: Pftk2, Als2cr7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 271697
Homologene: 64641
Tcf19
Name: transcription factor 19
Synonyms: 5730403J10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106795
Homologene: 5156
Cfap61
Name: cilia and flagella associated protein 61
Synonyms: 4930529M08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78774
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, Clca3, gob-5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: Crmp5, CRMP-5, CRAM
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65254
Homologene: 41347
Mrgprb5
Name: MAS-related GPR, member B5
Synonyms: MrgB5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404239
Homologene: 115575
Fastkd3
Name: FAST kinase domains 3
Synonyms: 2310010B21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69577
VEGA: 13
Homologene: 11457
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: 2900079B22Rik, P2Y12, 4921504D23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Or4d10
Name: olfactory receptor family 4 subfamily D member 10
Synonyms: GA_x6K02T2RE5P-2433425-2432490, MOR239-7, Olfr1425
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258155
Homologene: 17398
Crisp4
Name: cysteine-rich secretory protein 4
Synonyms: 9230112K08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78081
HGNC: HGNC:304
Homologene: 81683
Rdh16f2
Name: RDH16 family member 2
Synonyms: BC089597
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216454
Homologene: 129514
Gm5591
Name: predicted gene 5591
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434171
Homologene: 80005
Akr1cl
Name: aldo-keto reductase family 1, member C-like
Synonyms: 4921521F21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70861
Homologene: 133861
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 18,122,738 bp
  • A to G, chromosome 1 at 51,763,906 bp
  • A to G, chromosome 1 at 59,289,695 bp
  • G to A, chromosome 1 at 65,016,678 bp
  • T to C, chromosome 1 at 72,393,973 bp
  • T to A, chromosome 2 at 28,545,889 bp
  • A to T, chromosome 2 at 37,816,979 bp
  • T to A, chromosome 2 at 41,671,057 bp
  • C to A, chromosome 2 at 69,432,213 bp
  • C to T, chromosome 2 at 69,459,674 bp
  • C to T, chromosome 2 at 94,375,150 bp
  • T to A, chromosome 2 at 145,580,982 bp
  • C to T, chromosome 2 at 146,153,838 bp
  • T to A, chromosome 2 at 162,934,716 bp
  • A to G, chromosome 3 at 30,607,052 bp
  • A to G, chromosome 3 at 59,217,211 bp
  • A to G, chromosome 3 at 145,027,427 bp
  • A to G, chromosome 3 at 146,458,818 bp
  • A to T, chromosome 4 at 118,868,822 bp
  • A to C, chromosome 5 at 30,778,887 bp
  • A to T, chromosome 5 at 120,919,991 bp
  • G to A, chromosome 5 at 142,144,976 bp
  • T to A, chromosome 5 at 149,204,272 bp
  • T to C, chromosome 6 at 40,746,332 bp
  • TGTCCAGCAAG to TG, chromosome 6 at 67,015,752 bp
  • A to C, chromosome 6 at 140,013,586 bp
  • A to C, chromosome 7 at 6,961,220 bp
  • A to C, chromosome 7 at 23,984,931 bp
  • A to T, chromosome 7 at 25,246,131 bp
  • C to T, chromosome 7 at 38,519,509 bp
  • C to T, chromosome 7 at 48,168,504 bp
  • T to C, chromosome 7 at 127,611,029 bp
  • A to G, chromosome 8 at 13,136,874 bp
  • A to G, chromosome 8 at 18,671,093 bp
  • A to G, chromosome 8 at 25,037,165 bp
  • A to G, chromosome 8 at 95,011,784 bp
  • T to C, chromosome 8 at 123,454,322 bp
  • A to T, chromosome 9 at 7,041,720 bp
  • T to C, chromosome 9 at 15,098,051 bp
  • A to T, chromosome 9 at 99,046,658 bp
  • A to G, chromosome 9 at 110,850,121 bp
  • T to A, chromosome 10 at 5,222,266 bp
  • T to C, chromosome 10 at 62,193,955 bp
  • T to C, chromosome 10 at 121,667,745 bp
  • A to G, chromosome 10 at 127,876,898 bp
  • T to C, chromosome 11 at 59,186,024 bp
  • T to A, chromosome 11 at 70,609,629 bp
  • CAGTATCTG to C, chromosome 11 at 100,246,784 bp
  • T to C, chromosome 11 at 106,053,735 bp
  • A to T, chromosome 12 at 13,393,498 bp
  • C to T, chromosome 12 at 40,328,730 bp
  • T to C, chromosome 12 at 70,197,010 bp
  • A to G, chromosome 13 at 57,436,085 bp
  • A to T, chromosome 13 at 68,591,960 bp
  • A to G, chromosome 15 at 8,232,080 bp
  • G to A, chromosome 15 at 76,452,272 bp
  • A to G, chromosome 15 at 76,601,750 bp
  • A to G, chromosome 15 at 82,066,240 bp
  • T to C, chromosome 15 at 85,907,673 bp
  • C to T, chromosome 16 at 35,647,203 bp
  • A to T, chromosome 16 at 69,858,077 bp
  • T to C, chromosome 16 at 90,258,770 bp
  • G to A, chromosome 17 at 34,876,010 bp
  • A to G, chromosome 17 at 35,514,531 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to C, chromosome 18 at 43,577,325 bp
  • A to G, chromosome 19 at 12,073,697 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7446 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045522-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.