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Strain Name:
C57BL/6J-MtgxR7459Btlr/Mmmh
Stock Number:
045533-MU
Citation ID:
RRID:MMRRC_045533-MU
Other Names:
R7459 (G1)
Major Collection:

Strain Information

Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Ndufa7
Name: NADH:ubiquinone oxidoreductase subunit A7
Synonyms: 2400007M02Rik, 14.5kDa, NADH oxidoreductase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66416
HGNC: HGNC:7691
Homologene: 37994
Prune1
Name: prune exopolyphosphatase
Synonyms: 9230112O05Rik, Prune-M1, Prune
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229589
Homologene: 41429
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: LOC328902, G430090F17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Lin7c
Name: lin-7 homolog C, crumbs cell polarity complex component
Synonyms: LIN-7-C, LIN-7C, Lin7c, MALS-3, Veli3, D2Ertd520e, 9130007B12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22343
Homologene: 22649
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: 4930506N09Rik, C2pa, PDZ-RGS3, RGS3S, C2PA-RGS3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,910,634 bp
  • A to T, chromosome 1 at 57,799,353 bp
  • T to G, chromosome 1 at 58,691,752 bp
  • C to A, chromosome 1 at 60,128,039 bp
  • T to A, chromosome 1 at 119,659,834 bp
  • A to C, chromosome 1 at 172,287,295 bp
  • A to G, chromosome 2 at 30,113,325 bp
  • C to A, chromosome 2 at 76,919,138 bp
  • G to A, chromosome 2 at 89,630,668 bp
  • T to A, chromosome 2 at 109,897,337 bp
  • T to G, chromosome 2 at 130,419,824 bp
  • T to C, chromosome 2 at 160,897,300 bp
  • T to C, chromosome 2 at 180,929,357 bp
  • G to A, chromosome 3 at 54,291,232 bp
  • T to C, chromosome 3 at 87,932,178 bp
  • C to A, chromosome 3 at 95,281,710 bp
  • C to A, chromosome 3 at 132,175,029 bp
  • C to T, chromosome 3 at 133,480,289 bp
  • T to C, chromosome 3 at 135,886,911 bp
  • T to A, chromosome 3 at 146,476,222 bp
  • A to G, chromosome 4 at 62,625,154 bp
  • A to T, chromosome 4 at 101,107,213 bp
  • T to G, chromosome 5 at 86,901,275 bp
  • C to A, chromosome 5 at 88,555,553 bp
  • A to C, chromosome 5 at 120,749,710 bp
  • A to G, chromosome 5 at 135,414,297 bp
  • A to C, chromosome 5 at 151,047,599 bp
  • C to T, chromosome 6 at 135,211,901 bp
  • G to T, chromosome 7 at 4,684,578 bp
  • A to T, chromosome 7 at 24,899,142 bp
  • A to G, chromosome 7 at 28,107,285 bp
  • G to A, chromosome 7 at 45,519,803 bp
  • A to T, chromosome 7 at 55,933,341 bp
  • G to T, chromosome 7 at 64,348,966 bp
  • G to A, chromosome 7 at 76,420,066 bp
  • A to T, chromosome 7 at 105,617,808 bp
  • A to G, chromosome 7 at 135,667,600 bp
  • T to A, chromosome 8 at 71,605,027 bp
  • A to G, chromosome 8 at 74,892,764 bp
  • T to G, chromosome 8 at 84,167,352 bp
  • C to A, chromosome 8 at 93,535,741 bp
  • T to A, chromosome 8 at 107,057,336 bp
  • T to C, chromosome 8 at 111,333,530 bp
  • C to T, chromosome 9 at 14,751,306 bp
  • T to C, chromosome 9 at 55,396,599 bp
  • A to G, chromosome 9 at 57,914,592 bp
  • T to A, chromosome 9 at 99,358,064 bp
  • A to G, chromosome 9 at 110,519,041 bp
  • T to C, chromosome 10 at 29,347,644 bp
  • A to C, chromosome 10 at 30,590,043 bp
  • C to T, chromosome 10 at 80,773,173 bp
  • A to G, chromosome 10 at 128,276,565 bp
  • A to T, chromosome 11 at 8,492,793 bp
  • A to T, chromosome 11 at 8,902,428 bp
  • T to A, chromosome 11 at 16,896,967 bp
  • T to A, chromosome 11 at 21,148,190 bp
  • A to T, chromosome 11 at 23,364,458 bp
  • T to C, chromosome 11 at 55,303,919 bp
  • A to G, chromosome 11 at 59,131,657 bp
  • C to A, chromosome 11 at 68,492,590 bp
  • T to A, chromosome 11 at 68,988,655 bp
  • A to T, chromosome 12 at 35,997,453 bp
  • T to C, chromosome 12 at 85,747,057 bp
  • G to A, chromosome 12 at 91,575,652 bp
  • C to T, chromosome 12 at 115,980,812 bp
  • T to C, chromosome 14 at 20,779,207 bp
  • A to T, chromosome 14 at 41,120,184 bp
  • A to G, chromosome 14 at 52,140,559 bp
  • T to G, chromosome 15 at 39,517,839 bp
  • T to C, chromosome 15 at 84,195,856 bp
  • C to T, chromosome 16 at 43,947,457 bp
  • A to T, chromosome 16 at 92,079,017 bp
  • A to G, chromosome 16 at 96,205,922 bp
  • C to T, chromosome 17 at 31,946,734 bp
  • T to A, chromosome 17 at 33,838,166 bp
  • T to C, chromosome 17 at 36,909,662 bp
  • T to A, chromosome 17 at 57,449,933 bp
  • T to C, chromosome 17 at 65,256,389 bp
  • C to T, chromosome 18 at 12,933,585 bp
  • A to T, chromosome 18 at 37,479,553 bp
  • T to A, chromosome 19 at 16,873,072 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7459 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045533-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.