Strain Name:
C57BL/6J-MtgxR7489Btlr/Mmmh
Stock Number:
045563-MU
Citation ID:
RRID:MMRRC_045563-MU
Other Names:
R7489 (G1)
Major Collection:

Strain Information

Kl
Name: klotho
Synonyms: alpha-kl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16591
HGNC: HGNC:6344
Homologene: 68415
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Dip2c
Name: disco interacting protein 2 homolog C
Synonyms: 2900024P20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 208440
Homologene: 40996
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: 6330404E16Rik, Btbd11
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Sipa1l3
Name: signal-induced proliferation-associated 1 like 3
Synonyms: 2610511M17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74206
Homologene: 77938
Zfr
Name: zinc finger RNA binding protein
Synonyms: C920030H05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22763
Homologene: 8009
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Rad51b
Name: RAD51 paralog B
Synonyms: mREC2, R51H2, Rad51b, Rad51l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19363
VEGA: 12
HGNC: HGNC:9822
Homologene: 50190
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: G2, Bat-2, D17H6S51E, Wbp12, 3110039B05Rik, Bat2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: C330019M07Rik, 2410041F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70024
Homologene: 41275
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71544
Homologene: 28446
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Ticam2
Name: TIR domain containing adaptor molecule 2
Synonyms: TRAM, Tirp
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225471
Homologene: 11014
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Ms4a14
Name: membrane-spanning 4-domains, subfamily A, member 14
Synonyms: LOC383435
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 383435
Homologene: 138453
Alas1
Name: aminolevulinic acid synthase 1
Synonyms: 5-aminolevulinate synthase, succinyl-CoA: glycine C-succinyl transferase, Alas-1, ALAS-N
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11655
HGNC: HGNC:396
Homologene: 55478
H2-M5
Name: histocompatibility 2, M region locus 5
Synonyms: H-2M5, D130003B22Rik, CRW2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240095
Homologene: 128812
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: 2310047C21Rik, D8Wsu49e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Lap3
Name: leucine aminopeptidase 3
Synonyms: Pep-S, Pep-7, LAP, peptidase S, Pep7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66988
Homologene: 41072
Med23
Name: mediator complex subunit 23
Synonyms: ESTM7, 3000002A17Rik, X83317, Crsp3, Sur2, sno
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70208
HGNC: HGNC:2372
Homologene: 3552
Slc12a9
Name: solute carrier family 12 (potassium/chloride transporters), member 9
Synonyms: CIP1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83704
Homologene: 5429
Pcdh12
Name: protocadherin 12
Synonyms: VE-cadherin-2, vascular endothelial cadherin-2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 53601
HGNC: HGNC:8657
Homologene: 9574
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: dunce, Dpde3, 9630011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Trpc6
Name: transient receptor potential cation channel, subfamily C, member 6
Synonyms: mtrp6, Trrp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22068
VEGA: 9
Homologene: 37944
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: A830096D10Rik, Bai3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Rab19
Name: RAB19, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19331
Homologene: 22623
Garin3
Name: golgi associated RAB2 interactor 3
Synonyms: OTTMUSG00000005491, Fam71b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432552
Homologene: 51067
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: A530024P18Rik, 2310008C07Rik, 2310003D02Rik, mXin beta, myomaxin, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Scyl3
Name: SCY1-like 3 (S. cerevisiae)
Synonyms: Pace1, 1200016D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240880
Homologene: 10706
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, STOP, 2810411E12Rik, Mtap6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67161
Homologene: 27031
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: 2310045L10Rik, Srcasm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71943
Homologene: 38055
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Apbb1
Name: amyloid beta precursor protein binding family B member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Nmrk1
Name: nicotinamide riboside kinase 1
Synonyms: D630020N23Rik, BC016495
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225994
Homologene: 6787
Bpifb4
Name: BPI fold containing family B, member 4
Synonyms: LOC381399, Gm1006
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381399
Homologene: 66971
Ces1d
Name: carboxylesterase 1D
Synonyms: TGH, Ces3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104158
HGNC: HGNC:1863
Homologene: 35606
Galnt1
Name: polypeptide N-acetylgalactosaminyltransferase 1
Synonyms: ppGaNTase-T1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14423
HGNC: HGNC:4123
Homologene: 8469
Cdx2
Name: caudal type homeobox 2
Synonyms: Cdx-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12591
HGNC: HGNC:1806
Homologene: 968
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Or6c70
Name: olfactory receptor family 6 subfamily C member 70
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-5, MOR113-8, Olfr814
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259165
Homologene: 133585
Mmp8
Name: matrix metallopeptidase 8
Synonyms: Collagenase-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17394
VEGA: 9
HGNC: HGNC:7175
Homologene: 22482
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230612
Homologene: 17081
Best1
Name: bestrophin 1
Synonyms: best macular dystrophy, mBest1, Vmd2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24115
Homologene: 37895
Zfp119a
Name: zinc finger protein 119a
Synonyms: Zfp119, Mzf13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 104349
Tdrd9
Name: tudor domain containing 9
Synonyms: 4930441E05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74691
Homologene: 14311
4930519G04Rik
Name: RIKEN cDNA 4930519G04 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67593
Homologene: 87032
Ces2e
Name: carboxylesterase 2E
Synonyms: 9030624L02Rik, Ces5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234673
HGNC: HGNC:1864
Homologene: 86210
Myzap
Name: myocardial zonula adherens protein
Synonyms: Grinl1a7, Myozap, Gcom1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102371
Homologene: 134156
Iqcf6
Name: IQ motif containing F6
Synonyms: 100041096
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100041096
Homologene: 67808
2310079G19Rik
Name: RIKEN cDNA 2310079G19 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69699
Homologene: 137381
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
Ucn2
Name: urocortin 2
Synonyms: Urocortin II, Ucn-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171530
Homologene: 50048
Lce1c
Name: late cornified envelope 1C
Synonyms: 1110014K05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73719
4930503E14Rik
Name: RIKEN cDNA 4930503E14 gene
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74954
Homologene: 115686
Or4x12-ps1
Name: olfactory receptor family 4 subfamily X member 12, pseudogene 1
Synonyms: GA_x6K02T2Q125-51518604-51517675, MOR228-1, Olfr1267-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258204
Mup14
Name: major urinary protein 14
Synonyms: Gm13514
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039116
Homologene: 74304
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 25,547,505 bp
  • T to A, chromosome 1 at 88,379,759 bp
  • A to G, chromosome 1 at 118,838,175 bp
  • T to C, chromosome 1 at 163,949,176 bp
  • T to A, chromosome 2 at 5,001,301 bp
  • A to C, chromosome 2 at 67,525,560 bp
  • T to A, chromosome 2 at 90,086,360 bp
  • A to C, chromosome 2 at 153,944,004 bp
  • A to T, chromosome 3 at 41,629,597 bp
  • G to A, chromosome 3 at 92,680,647 bp
  • A to G, chromosome 4 at 61,303,888 bp
  • T to C, chromosome 4 at 111,526,658 bp
  • C to A, chromosome 4 at 111,883,916 bp
  • G to A, chromosome 4 at 152,373,468 bp
  • C to T, chromosome 5 at 4,004,933 bp
  • T to C, chromosome 5 at 45,500,506 bp
  • T to C, chromosome 5 at 108,797,656 bp
  • T to C, chromosome 5 at 114,879,625 bp
  • T to C, chromosome 5 at 122,467,767 bp
  • C to A, chromosome 5 at 137,322,820 bp
  • A to T, chromosome 5 at 147,306,672 bp
  • A to T, chromosome 5 at 150,952,996 bp
  • A to G, chromosome 6 at 39,388,105 bp
  • T to C, chromosome 6 at 48,473,713 bp
  • C to T, chromosome 6 at 57,843,892 bp
  • T to C, chromosome 6 at 113,564,304 bp
  • A to T, chromosome 6 at 121,226,021 bp
  • A to G, chromosome 7 at 29,366,702 bp
  • A to T, chromosome 7 at 96,837,314 bp
  • C to T, chromosome 7 at 99,268,061 bp
  • G to T, chromosome 7 at 105,567,480 bp
  • A to C, chromosome 8 at 71,684,292 bp
  • C to T, chromosome 8 at 85,767,001 bp
  • A to T, chromosome 8 at 93,178,131 bp
  • A to G, chromosome 8 at 104,929,780 bp
  • A to T, chromosome 9 at 7,561,387 bp
  • T to A, chromosome 9 at 8,656,544 bp
  • A to G, chromosome 9 at 9,006,358 bp
  • T to A, chromosome 9 at 71,561,038 bp
  • A to T, chromosome 9 at 106,241,634 bp
  • C to A, chromosome 9 at 106,627,457 bp
  • C to T, chromosome 9 at 108,986,254 bp
  • T to C, chromosome 10 at 20,963,750 bp
  • T to A, chromosome 10 at 24,904,356 bp
  • T to A, chromosome 10 at 85,627,215 bp
  • A to T, chromosome 10 at 129,874,682 bp
  • G to C, chromosome 11 at 46,407,441 bp
  • C to T, chromosome 11 at 83,990,825 bp
  • T to C, chromosome 11 at 90,656,359 bp
  • C to T, chromosome 12 at 79,300,585 bp
  • A to G, chromosome 12 at 112,067,637 bp
  • T to C, chromosome 13 at 9,533,312 bp
  • T to A, chromosome 13 at 93,091,838 bp
  • C to A, chromosome 13 at 109,116,767 bp
  • A to T, chromosome 14 at 44,170,299 bp
  • T to A, chromosome 15 at 12,152,982 bp
  • A to C, chromosome 15 at 101,793,859 bp
  • A to T, chromosome 16 at 88,627,234 bp
  • A to T, chromosome 17 at 35,162,354 bp
  • A to C, chromosome 17 at 36,989,471 bp
  • A to T, chromosome 17 at 55,866,158 bp
  • A to T, chromosome 17 at 57,250,966 bp
  • T to A, chromosome 18 at 24,282,157 bp
  • T to C, chromosome 18 at 38,281,789 bp
  • T to A, chromosome 18 at 46,560,517 bp
  • A to G, chromosome 19 at 9,997,046 bp
  • T to C, chromosome 19 at 11,302,031 bp
  • A to T, chromosome 19 at 18,642,242 bp
  • G to T, chromosome 19 at 18,642,243 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7489 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045563-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.