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Strain Name:
C57BL/6J-MtgxR7505Btlr/Mmmh
Stock Number:
045578-MU
Citation ID:
RRID:MMRRC_045578-MU
Other Names:
R7505 (G1)
Major Collection:

Strain Information

Fgf4
Name: fibroblast growth factor 4
Synonyms: Hst1, kFGF, Fgf-4, Hstf-1, Fgfk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14175
HGNC: HGNC:3682
Homologene: 1522
Msi2
Name: musashi RNA-binding protein 2
Synonyms: msi2h, Musashi2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76626
Homologene: 62199
Atp6v1h
Name: ATPase, H+ transporting, lysosomal V1 subunit H
Synonyms: 0710001F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108664
Homologene: 7139
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Sar1a
Name: secretion associated Ras related GTPase 1A
Synonyms: 1600019H17Rik, Sara1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20224
VEGA: 10
Homologene: 90897
Gars1
Name: glycyl-tRNA synthetase 1
Synonyms: Sgrp23, GENA202, Gena201, Gars
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353172
HGNC: HGNC:4162
Homologene: 1547
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 5,124,338 bp
  • T to C, chromosome 1 at 22,533,996 bp
  • A to G, chromosome 1 at 67,180,081 bp
  • A to G, chromosome 1 at 89,928,733 bp
  • C to T, chromosome 1 at 136,085,449 bp
  • A to T, chromosome 2 at 6,624,700 bp
  • T to A, chromosome 2 at 76,778,554 bp
  • A to T, chromosome 2 at 112,712,429 bp
  • T to G, chromosome 2 at 118,791,088 bp
  • A to T, chromosome 2 at 122,075,351 bp
  • A to G, chromosome 2 at 130,284,227 bp
  • G to C, chromosome 2 at 130,284,233 bp
  • A to G, chromosome 3 at 93,526,032 bp
  • G to T, chromosome 3 at 155,086,776 bp
  • T to C, chromosome 4 at 41,120,352 bp
  • T to C, chromosome 4 at 58,115,862 bp
  • T to A, chromosome 4 at 106,379,079 bp
  • A to G, chromosome 4 at 143,949,703 bp
  • C to T, chromosome 4 at 143,964,986 bp
  • T to G, chromosome 4 at 145,269,115 bp
  • T to A, chromosome 5 at 11,131,168 bp
  • T to A, chromosome 5 at 30,371,020 bp
  • T to A, chromosome 5 at 90,469,509 bp
  • A to T, chromosome 5 at 138,179,945 bp
  • A to G, chromosome 6 at 41,674,656 bp
  • A to G, chromosome 6 at 55,052,177 bp
  • T to A, chromosome 7 at 23,407,500 bp
  • T to C, chromosome 7 at 28,089,674 bp
  • T to A, chromosome 7 at 85,957,071 bp
  • C to A, chromosome 7 at 140,638,052 bp
  • C to T, chromosome 7 at 142,156,590 bp
  • T to C, chromosome 7 at 144,861,761 bp
  • A to T, chromosome 8 at 13,028,745 bp
  • A to T, chromosome 8 at 47,880,150 bp
  • A to T, chromosome 8 at 94,548,466 bp
  • G to A, chromosome 8 at 122,848,492 bp
  • G to C, chromosome 9 at 121,976,417 bp
  • A to G, chromosome 10 at 41,487,354 bp
  • A to G, chromosome 10 at 61,691,294 bp
  • A to G, chromosome 10 at 79,737,883 bp
  • A to G, chromosome 10 at 79,743,176 bp
  • G to T, chromosome 10 at 93,707,284 bp
  • A to G, chromosome 10 at 100,516,265 bp
  • A to G, chromosome 10 at 128,390,055 bp
  • T to C, chromosome 11 at 50,796,520 bp
  • A to T, chromosome 11 at 88,413,917 bp
  • C to T, chromosome 11 at 103,380,029 bp
  • A to G, chromosome 11 at 116,226,987 bp
  • A to G, chromosome 12 at 17,297,723 bp
  • A to T, chromosome 12 at 87,773,500 bp
  • A to T, chromosome 12 at 100,132,498 bp
  • T to A, chromosome 12 at 113,304,980 bp
  • A to T, chromosome 13 at 8,819,935 bp
  • G to T, chromosome 13 at 12,221,476 bp
  • T to A, chromosome 13 at 21,368,586 bp
  • T to C, chromosome 13 at 55,075,631 bp
  • A to G, chromosome 13 at 58,399,969 bp
  • G to T, chromosome 13 at 69,506,928 bp
  • C to T, chromosome 14 at 29,045,544 bp
  • A to G, chromosome 14 at 42,310,357 bp
  • G to T, chromosome 14 at 54,710,656 bp
  • G to A, chromosome 14 at 56,083,091 bp
  • G to A, chromosome 15 at 3,971,421 bp
  • A to T, chromosome 15 at 71,799,399 bp
  • A to T, chromosome 15 at 76,181,194 bp
  • T to A, chromosome 15 at 91,149,057 bp
  • A to G, chromosome 17 at 43,627,679 bp
  • T to A, chromosome 17 at 49,096,451 bp
  • T to A, chromosome 17 at 56,109,357 bp
  • A to T, chromosome 17 at 75,538,238 bp
  • A to G, chromosome 19 at 10,858,673 bp
  • T to A, chromosome 19 at 12,074,605 bp
  • C to T, chromosome 19 at 44,543,707 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7505 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045578-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.