Strain Name:
C57BL/6J-MtgxR7508Btlr/Mmmh
Stock Number:
045581-MU
Citation ID:
RRID:MMRRC_045581-MU
Other Names:
R7508 (G1)
Major Collection:

Strain Information

Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Clasp1
Name: CLIP associating protein 1
Synonyms: CLASP1alpha, CLASP1, mCLASP1, 1700030C23Rik, 5730583A19Rik, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Taok1
Name: TAO kinase 1
Synonyms: D130018F14Rik, 2810468K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216965
Homologene: 27041
Rbm25
Name: RNA binding motif protein 25
Synonyms: A130095G20Rik, 2600011C06Rik, 2610015J01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: Nkcc1, mBSC2, sodium/potassium/chloride cotransporters, sy-ns
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Zfp512
Name: zinc finger protein 512
Synonyms: 2500002M11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269639
Homologene: 13026
Sgo2a
Name: shugoshin 2A
Synonyms: 1110007N04Rik, Sgol2, Tripin, 5730576N04Rik, Sgol2a, D1Ertd8e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68549
Homologene: 51867
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Wars1
Name: tryptophanyl-tRNA synthetase1
Synonyms: Wars
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22375
Homologene: 3084
Lyl1
Name: lymphoblastomic leukemia 1
Synonyms: Lyl-1, bHLHa18
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17095
VEGA: 8
HGNC: HGNC:6734
Homologene: 4078
Zfp369
Name: zinc finger protein 369
Synonyms: B930030B22Rik, NRIF2, D230020H11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 170936
Homologene: 129707
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: 3830613O22Rik, Tem5-like, Gpr125
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70693
Homologene: 19235
Gcnt2
Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Synonyms: IGnTC, 5330430K10Rik, IGnTA, IGnTB, IGnT
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14538
VEGA: 13
HGNC: HGNC:4204
Homologene: 41535
Kirrel1
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Kirrel, Kirrel1, 6720469N11Rik, Neph1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170643
Homologene: 10089
Dna2
Name: DNA replication helicase/nuclease 2
Synonyms: E130315B21Rik, Dna2l
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327762
HGNC: HGNC:2939
Homologene: 6124
Prf1
Name: perforin 1 (pore forming protein)
Synonyms: perforin, Pfn, Prf-1, Pfp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18646
VEGA: 10
HGNC: HGNC:9360
Homologene: 3698
Egln3
Name: egl-9 family hypoxia-inducible factor 3
Synonyms: Hif-p4h-3, 2610021G09Rik, SM-20, Phd3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 112407
Homologene: 32531
Slc9a5
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 5
Synonyms: LOC277973
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277973
Homologene: 31247
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Rnpep
Name: arginyl aminopeptidase (aminopeptidase B)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215615
Homologene: 10628
Pde5a
Name: phosphodiesterase 5A, cGMP-specific
Synonyms: PDE5A1, Pde5
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242202
HGNC: HGNC:8784
Homologene: 842
Ccser1
Name: coiled-coil serine rich 1
Synonyms: Fam190a, C130092O11Rik, 6230405M12Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232035
Homologene: 28086
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 252868
Homologene: 17099
Ctsg
Name: cathepsin G
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13035
VEGA: 14
HGNC: HGNC:2532
Homologene: 105646
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 1700040C17Rik, 4930503C18Rik, 2610033K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73296
Homologene: 8932
Spag16
Name: sperm associated antigen 16
Synonyms: 4921511D23Rik, 4930585K05Rik, 4930524F24Rik, Pf20, Wdr29
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66722
Homologene: 11572
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55963
Homologene: 20655
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Adgrc3, flamingo, Fmi1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Dnai1
Name: dynein axonemal intermediate chain 1
Synonyms: 1110066F04Rik, b2b1526Clo, Dnaic1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68922
HGNC: HGNC:2954
Homologene: 8122
Slc29a4
Name: solute carrier family 29 (nucleoside transporters), member 4
Synonyms: mPMAT, ENT4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243328
Homologene: 71345
Tm4sf1
Name: transmembrane 4 superfamily member 1
Synonyms: L6 antigen, 12A8 target antigen, M3s1, L6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17112
Homologene: 7409
Cylc2
Name: cylicin, basic protein of sperm head cytoskeleton 2
Synonyms: 4930488P18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74914
HGNC: HGNC:2583
Homologene: 136270
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58909
Homologene: 135847
Gpd1
Name: glycerol-3-phosphate dehydrogenase 1 (soluble)
Synonyms: Gdc1, Gdc-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14555
HGNC: HGNC:4455
Homologene: 5593
Zfp952
Name: zinc finger protein 952
Synonyms: C920016K16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240067
Homologene: 128790
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: GA_x6K02T2QHY8-11597382-11598323, Olfr11, MOR256-11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Neurl1b
Name: neuralized E3 ubiquitin protein ligase 1B
Synonyms: EG240055, C230078M08Rik, Neur2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240055
Homologene: 35443
Hacd4
Name: 3-hydroxyacyl-CoA dehydratase 4
Synonyms: Ptplad2, 4933428I03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66775
Homologene: 12033
Usp49
Name: ubiquitin specific peptidase 49
Synonyms: C330046L10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224836
Homologene: 10235
Adra1a
Name: adrenergic receptor, alpha 1a
Synonyms: Adra1c
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11549
HGNC: HGNC:277
Homologene: 68078
Pgc
Name: progastricsin (pepsinogen C)
Synonyms: Upg1, 2210410L06Rik, Upg-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109820
HGNC: HGNC:8890
Homologene: 55669
Klra7
Name: killer cell lectin-like receptor, subfamily A, member 7
Synonyms: Ly-49G.3, Ly49g2, Ly49g1, LGL-1, Ly-49G.2, Ly49g, Ly-49G.1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16638
Homologene: 110821
Vmn2r32
Name: vomeronasal 2, receptor 32
Synonyms: V2r5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22311
Homologene: 113703
Cmtm6
Name: CKLF-like MARVEL transmembrane domain containing 6
Synonyms: 2810051A14Rik, Cklfsf6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67213
VEGA: 9
Homologene: 9845
Zbp1
Name: Z-DNA binding protein 1
Synonyms: mZaDLM, 2010010H03Rik, Dai
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58203
Homologene: 10972
Or8u3-ps
Name: olfactory receptor family 8 subfamily U member 3
Synonyms: Olfr1038-ps, GA_x6K02T2Q125-47591072-47592031, MOR185-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259015
Homologene: 17463
Ighv1-26
Name: immunoglobulin heavy variable 1-26
Synonyms: Gm16717
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629884
Eif1ad12
Name: eukaryotic translation initiation factor 1A domain containing 12
Synonyms: Gm5788
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 544883
VEGA: 12
Traj6
Name: T cell receptor alpha joining 6
Synonyms: Gm16920
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124397
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,017,795 bp
  • A to T, chromosome 1 at 69,887,520 bp
  • A to G, chromosome 1 at 71,597,516 bp
  • A to G, chromosome 1 at 74,687,259 bp
  • T to A, chromosome 1 at 118,545,434 bp
  • A to G, chromosome 1 at 135,278,858 bp
  • T to A, chromosome 2 at 72,205,733 bp
  • A to G, chromosome 2 at 86,121,938 bp
  • T to A, chromosome 2 at 173,207,811 bp
  • A to G, chromosome 3 at 57,294,755 bp
  • T to C, chromosome 3 at 87,083,439 bp
  • A to G, chromosome 3 at 122,818,030 bp
  • G to A, chromosome 4 at 41,614,323 bp
  • T to A, chromosome 4 at 51,229,256 bp
  • A to G, chromosome 4 at 88,437,478 bp
  • A to G, chromosome 4 at 149,654,583 bp
  • C to G, chromosome 5 at 31,473,539 bp
  • C to T, chromosome 5 at 50,016,867 bp
  • C to T, chromosome 5 at 142,718,506 bp
  • T to A, chromosome 6 at 48,466,699 bp
  • A to T, chromosome 6 at 58,987,284 bp
  • A to G, chromosome 6 at 61,570,723 bp
  • A to T, chromosome 6 at 130,230,091 bp
  • C to T, chromosome 7 at 7,467,374 bp
  • T to A, chromosome 7 at 59,303,689 bp
  • T to C, chromosome 8 at 71,354,801 bp
  • T to C, chromosome 8 at 84,704,300 bp
  • T to A, chromosome 8 at 105,363,253 bp
  • T to A, chromosome 9 at 108,836,622 bp
  • A to G, chromosome 9 at 114,731,240 bp
  • G to A, chromosome 10 at 61,300,155 bp
  • A to G, chromosome 10 at 62,971,993 bp
  • C to T, chromosome 10 at 116,353,991 bp
  • T to C, chromosome 10 at 120,105,283 bp
  • A to C, chromosome 10 at 123,023,939 bp
  • A to T, chromosome 11 at 20,306,487 bp
  • T to C, chromosome 11 at 50,145,120 bp
  • A to T, chromosome 11 at 68,922,423 bp
  • T to A, chromosome 11 at 77,545,326 bp
  • T to C, chromosome 12 at 54,180,628 bp
  • T to C, chromosome 12 at 83,672,877 bp
  • T to C, chromosome 12 at 87,494,842 bp
  • A to G, chromosome 12 at 108,882,875 bp
  • C to T, chromosome 12 at 112,774,405 bp
  • G to A, chromosome 12 at 114,788,442 bp
  • T to A, chromosome 13 at 21,638,609 bp
  • T to A, chromosome 13 at 40,887,681 bp
  • T to C, chromosome 13 at 65,279,273 bp
  • C to T, chromosome 13 at 75,878,857 bp
  • C to T, chromosome 14 at 54,212,714 bp
  • A to G, chromosome 14 at 56,100,541 bp
  • A to C, chromosome 14 at 66,637,935 bp
  • T to G, chromosome 15 at 21,583,765 bp
  • G to A, chromosome 15 at 99,722,086 bp
  • C to G, chromosome 17 at 26,438,746 bp
  • A to G, chromosome 17 at 33,003,782 bp
  • G to A, chromosome 17 at 47,672,280 bp
  • A to G, chromosome 17 at 47,734,186 bp
  • T to C, chromosome 18 at 57,904,393 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7508 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045581-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.