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Strain Name:
C57BL/6J-MtgxR7555Btlr/Mmmh
Stock Number:
045623-MU
Citation ID:
RRID:MMRRC_045623-MU
Other Names:
R7555 (G1)
Major Collection:

Strain Information

Mafb
Name: MAF bZIP transcription factor B
Synonyms: Kreisler, Krml1, Krml
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16658
HGNC: HGNC:6408
Homologene: 31315
Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Armc9
Name: armadillo repeat containing 9
Synonyms: 5730415N24Rik, 3830422A13Rik, 4831423D23Rik, 4930438O05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78795
Homologene: 11847
Aspscr1
Name: ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms: ASPCR1, RCC17, ASPC, 1190006K01Rik, TUG, ASPL
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68938
Homologene: 41550
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 86,275,678 bp
  • G to A, chromosome 1 at 91,435,135 bp
  • A to G, chromosome 1 at 150,604,874 bp
  • T to C, chromosome 1 at 173,972,221 bp
  • G to A, chromosome 1 at 175,687,890 bp
  • T to A, chromosome 1 at 181,770,054 bp
  • T to A, chromosome 2 at 14,996,339 bp
  • G to A, chromosome 2 at 25,255,730 bp
  • G to A, chromosome 2 at 32,288,166 bp
  • A to C, chromosome 2 at 86,509,347 bp
  • C to A, chromosome 2 at 90,791,555 bp
  • T to A, chromosome 2 at 118,417,283 bp
  • C to T, chromosome 2 at 131,138,476 bp
  • T to C, chromosome 2 at 160,365,829 bp
  • A to G, chromosome 3 at 86,987,101 bp
  • T to A, chromosome 3 at 126,438,236 bp
  • T to C, chromosome 4 at 11,169,750 bp
  • T to C, chromosome 4 at 58,069,422 bp
  • T to C, chromosome 4 at 118,689,642 bp
  • C to T, chromosome 4 at 128,452,458 bp
  • G to T, chromosome 4 at 138,901,885 bp
  • T to C, chromosome 4 at 144,332,741 bp
  • T to A, chromosome 4 at 144,522,354 bp
  • A to G, chromosome 4 at 147,826,132 bp
  • G to A, chromosome 4 at 151,018,058 bp
  • G to T, chromosome 4 at 154,041,817 bp
  • T to C, chromosome 5 at 9,570,000 bp
  • A to T, chromosome 5 at 11,597,612 bp
  • T to C, chromosome 5 at 35,042,628 bp
  • G to A, chromosome 5 at 105,236,149 bp
  • T to C, chromosome 5 at 109,171,691 bp
  • A to G, chromosome 5 at 123,157,757 bp
  • A to G, chromosome 5 at 130,274,706 bp
  • A to G, chromosome 6 at 82,914,056 bp
  • A to T, chromosome 6 at 89,715,044 bp
  • A to C, chromosome 6 at 134,685,979 bp
  • C to T, chromosome 7 at 18,817,094 bp
  • T to C, chromosome 7 at 25,060,597 bp
  • A to C, chromosome 7 at 29,189,814 bp
  • C to A, chromosome 7 at 30,569,410 bp
  • A to G, chromosome 7 at 46,913,411 bp
  • G to C, chromosome 7 at 108,622,726 bp
  • A to T, chromosome 7 at 122,170,241 bp
  • A to G, chromosome 7 at 125,645,670 bp
  • A to T, chromosome 7 at 143,694,933 bp
  • A to G, chromosome 8 at 4,234,363 bp
  • A to G, chromosome 8 at 70,289,413 bp
  • T to C, chromosome 8 at 89,033,158 bp
  • C to A, chromosome 8 at 122,887,406 bp
  • T to A, chromosome 9 at 26,893,628 bp
  • A to C, chromosome 9 at 64,311,937 bp
  • G to A, chromosome 10 at 13,507,430 bp
  • A to T, chromosome 10 at 28,781,702 bp
  • C to T, chromosome 10 at 62,598,243 bp
  • G to T, chromosome 10 at 70,956,291 bp
  • A to G, chromosome 10 at 106,927,826 bp
  • G to T, chromosome 10 at 127,546,862 bp
  • G to A, chromosome 11 at 69,106,513 bp
  • A to G, chromosome 11 at 70,650,797 bp
  • C to A, chromosome 11 at 104,298,702 bp
  • C to T, chromosome 11 at 120,673,100 bp
  • A to T, chromosome 12 at 41,452,911 bp
  • A to C, chromosome 12 at 87,494,735 bp
  • T to C, chromosome 12 at 110,630,625 bp
  • T to A, chromosome 13 at 16,017,637 bp
  • C to T, chromosome 13 at 51,149,049 bp
  • G to T, chromosome 13 at 64,072,002 bp
  • C to T, chromosome 13 at 112,927,642 bp
  • A to T, chromosome 14 at 36,879,500 bp
  • A to T, chromosome 14 at 52,075,153 bp
  • G to T, chromosome 14 at 54,437,742 bp
  • A to G, chromosome 15 at 11,036,276 bp
  • A to T, chromosome 15 at 44,550,761 bp
  • A to G, chromosome 15 at 101,143,473 bp
  • T to A, chromosome 15 at 103,897,445 bp
  • T to C, chromosome 16 at 11,400,942 bp
  • T to C, chromosome 16 at 37,323,603 bp
  • A to G, chromosome 16 at 58,448,718 bp
  • T to C, chromosome 16 at 91,658,922 bp
  • T to A, chromosome 17 at 20,227,675 bp
  • C to A, chromosome 17 at 24,701,976 bp
  • G to T, chromosome 17 at 25,963,432 bp
  • T to C, chromosome 17 at 42,672,603 bp
  • C to A, chromosome 17 at 85,687,707 bp
  • A to T, chromosome 18 at 37,335,279 bp
  • C to T, chromosome 18 at 77,395,365 bp
  • A to G, chromosome 19 at 25,175,400 bp
  • T to C, chromosome 19 at 36,612,403 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7555 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045623-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.