Strain Name:
C57BL/6J-MtgxR7592Btlr/Mmmh
Stock Number:
045639-MU
Citation ID:
RRID:MMRRC_045639-MU
Other Names:
R7592 (G1)
Major Collection:

Strain Information

Npr1
Name: natriuretic peptide receptor 1
Synonyms: guanylyl cyclase-A, NPRA, GC-A, NPR-A
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18160
HGNC: HGNC:7943
Homologene: 37367
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Elavl2
Name: ELAV like RNA binding protein 1
Synonyms: Hub, mel-N1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15569
HGNC: HGNC:3313
Homologene: 20930
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: C030045D06Rik, 6230420N16Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Supt20
Name: SPT20 SAGA complex component
Synonyms: p38IP, D3Ertd300e, Fam48a, p38 interacting protein
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56790
Homologene: 134155
Scaf8
Name: SR-related CTD-associated factor 8
Synonyms: A930036P18Rik, A630086M08Rik, Rbm16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106583
VEGA: 17
Homologene: 8928
Prom1
Name: prominin 1
Synonyms: Prom-1, Prom, AC133, 4932416E19Rik, CD133
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19126
HGNC: HGNC:9454
Homologene: 4390
Ccnk
Name: cyclin K
Synonyms: CPR4, CycK
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12454
VEGA: 12
HGNC: HGNC:1596
Homologene: 14748
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 97484
Homologene: 13018
Poc1a
Name: POC1 centriolar protein A
Synonyms: 2510040D07Rik, cha, Wdr51a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70235
Homologene: 51460
Crispld1
Name: cysteine-rich secretory protein LCCL domain containing 1
Synonyms: Cocoacrisp
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 83691
Homologene: 12857
Septin9
Name: septin 9
Synonyms: Sept9, PNUTL4, MSF1, Sint1, Msf, SL3-3 integration site 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Slc38a9
Name: solute carrier family 38, member 9
Synonyms: 9430067K09Rik, 9130023D20Rik, 4833412L08Rik, 6720411P22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268706
VEGA: 13
Homologene: 18139
Ift43
Name: intraflagellar transport 43
Synonyms: 1700019E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76411
VEGA: 12
Homologene: 12641
Emc1
Name: ER membrane protein complex subunit 1
Synonyms: C230096C10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230866
Homologene: 9002
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: tumstatin, alpha3(IV)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Capn1
Name: calpain 1
Synonyms: mu-calpin, Capa1, Capa-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12333
VEGA: 19
HGNC: HGNC:1476
Homologene: 3800
Psma1
Name: proteasome subunit alpha 1
Synonyms: HC2, C2, Pros-30
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26440
HGNC: HGNC:9530
Homologene: 2080
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, Mtsh1, D18Bwg1409e, teashirt1, Tsh1, NY-CO-33, Sdccag33
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Stil
Name: Scl/Tal1 interrupting locus
Synonyms: Sil
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20460
Homologene: 2283
4930562C15Rik
Name: RIKEN cDNA 4930562C15 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78809
Homologene: 53527
Cebpe
Name: CCAAT/enhancer binding protein epsilon
Synonyms: C/EBPepsilon, LOC239097, C/EBPe, CRP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110794
VEGA: 14
HGNC: HGNC:1836
Homologene: 1367
Mgat3
Name: mannoside acetylglucosaminyltransferase 3
Synonyms: GnT-III, 1110038J12Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17309
VEGA: 15
HGNC: HGNC:7046
Homologene: 31088
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Gucy2e
Name: guanylate cyclase 2e
Synonyms: GC1, ROS-GC1, GC-E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14919
HGNC: HGNC:4689
Homologene: 55442
Nudt12
Name: nudix hydrolase 12
Synonyms: nudix (nucleoside diphosphate linked moiety X)-type motif 12, 0610016O18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67993
Homologene: 44188
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: b2b1654Clo, Ccdc164, Gm1060, LOC381738
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Hip1r
Name: huntingtin interacting protein 1 related
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29816
Homologene: 78348
Vmn1r39
Name: vomeronasal 1 receptor 39
Synonyms: Gm5993
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546903
Homologene: 110800
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: OTTMUSG00000020811, A116
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 613123
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Aurkc
Name: aurora kinase C
Synonyms: IAK3, Stk13, AIE1, AIK3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20871
Homologene: 68302
Ankrd13b
Name: ankyrin repeat domain 13b
Synonyms: B930093C12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268445
Homologene: 27367
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: C2GNT3, LOC218476, LOC238786, Gm73
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218476
VEGA: 13
Homologene: 41144
Or2a20
Name: olfactory receptor family 2 subfamily A member 2
Synonyms: Olfr434, MOR261-10, GA_x6K02T2P3E9-4341246-4340281
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258366
Homologene: 133700
Or7g31
Name: olfactory receptor family 7 subfamily G member 31
Synonyms: MOR147-2, GA_x6K02T2PVTD-13214162-13213224, Olfr850
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258516
HGNC: HGNC:8466
Homologene: 121552
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Cers3
Name: ceramide synthase 3
Synonyms: T3L, 4930550L11Rik, Lass3, CerS3, LOC233330, related to TRH3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 545975
Homologene: 18719
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Slc2a12
Name: solute carrier family 2 (facilitated glucose transporter), member 12
Synonyms: GLUT-12, Glut12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 353169
Homologene: 59263
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Or51l4
Name: olfactory receptor family 51 subfamily L member 4
Synonyms: MOR17-1, GA_x6K02T2PBJ9-6483085-6482126, Olfr630
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259102
Homologene: 133674
Cstdc5
Name: cystatin domain containing 5
Synonyms: BC100530
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 100034684
HGNC: HGNC:2481
Homologene: 104045
Tmem181a
Name: transmembrane protein 181A
Synonyms: Tmem181, Gpr178, 5930418K15Rik, C76977
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77106
Homologene: 44787
Gsg1l2
Name: GSG1-like 2
Synonyms: Gm12302
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544792
Homologene: 132038
Pudp
Name: pseudouridine 5'-phosphatase
Synonyms: Hdhd1a, 1700121L12Rik, GS1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67365
VEGA: 18
Homologene: 8093
Hoxa4
Name: homeobox A4
Synonyms: Hox-1.4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15401
HGNC: HGNC:5105
Homologene: 37583
Rab15
Name: RAB15, member RAS oncogene family
Synonyms: 2310012G06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104886
Homologene: 64471
Trav21-dv12
Name: T cell receptor alpha variable 21-DV12
Synonyms: Gm13892
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100101940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,123,213 bp
  • A to T, chromosome 1 at 17,728,766 bp
  • T to C, chromosome 1 at 71,288,677 bp
  • A to G, chromosome 1 at 82,648,617 bp
  • T to A, chromosome 1 at 88,088,182 bp
  • A to G, chromosome 3 at 54,707,122 bp
  • C to A, chromosome 3 at 89,353,292 bp
  • T to G, chromosome 3 at 90,465,016 bp
  • T to A, chromosome 3 at 125,570,787 bp
  • A to T, chromosome 4 at 91,311,571 bp
  • T to A, chromosome 4 at 115,023,808 bp
  • T to C, chromosome 4 at 123,410,893 bp
  • A to G, chromosome 4 at 128,463,798 bp
  • A to G, chromosome 4 at 139,360,566 bp
  • A to G, chromosome 5 at 30,341,716 bp
  • T to C, chromosome 5 at 44,063,127 bp
  • A to G, chromosome 5 at 123,997,973 bp
  • T to G, chromosome 6 at 43,217,245 bp
  • T to C, chromosome 6 at 52,191,540 bp
  • C to A, chromosome 6 at 66,804,444 bp
  • C to T, chromosome 7 at 7,000,007 bp
  • G to A, chromosome 7 at 65,658,871 bp
  • G to A, chromosome 7 at 66,789,629 bp
  • A to G, chromosome 7 at 82,337,251 bp
  • GAAAA to GAAAAA, chromosome 7 at 85,411,560 bp
  • C to A, chromosome 7 at 103,755,072 bp
  • A to T, chromosome 7 at 114,269,726 bp
  • A to T, chromosome 8 at 107,050,229 bp
  • C to A, chromosome 9 at 19,477,832 bp
  • T to A, chromosome 9 at 20,797,393 bp
  • A to T, chromosome 9 at 106,349,768 bp
  • A to G, chromosome 10 at 22,664,903 bp
  • A to G, chromosome 11 at 67,774,758 bp
  • A to T, chromosome 11 at 69,223,324 bp
  • A to C, chromosome 11 at 77,476,501 bp
  • T to C, chromosome 11 at 77,978,050 bp
  • T to A, chromosome 11 at 117,290,662 bp
  • T to A, chromosome 12 at 76,804,449 bp
  • G to A, chromosome 12 at 86,161,190 bp
  • T to C, chromosome 12 at 108,186,465 bp
  • G to A, chromosome 13 at 96,947,161 bp
  • T to A, chromosome 13 at 112,695,355 bp
  • A to G, chromosome 14 at 30,908,765 bp
  • T to A, chromosome 14 at 50,186,563 bp
  • G to T, chromosome 14 at 53,876,540 bp
  • T to A, chromosome 14 at 54,711,841 bp
  • A to G, chromosome 15 at 80,210,992 bp
  • A to G, chromosome 16 at 4,849,274 bp
  • A to T, chromosome 16 at 36,367,500 bp
  • T to C, chromosome 17 at 3,171,222 bp
  • C to A, chromosome 17 at 6,289,020 bp
  • G to A, chromosome 17 at 19,591,181 bp
  • T to C, chromosome 17 at 59,006,594 bp
  • A to T, chromosome 18 at 50,567,982 bp
  • T to C, chromosome 18 at 84,014,048 bp
  • T to C, chromosome 19 at 6,014,439 bp
  • T to C, chromosome 19 at 36,056,892 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045639-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.