Strain Name:
C57BL/6J-MtgxR7649Btlr/Mmmh
Stock Number:
045646-MU
Citation ID:
RRID:MMRRC_045646-MU
Other Names:
R7649 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: Spnb4, dyn, 5830426A08Rik, 1700022P15Rik, nmf261, SpbIV, ROSA62, neuroaxonal dystrophy
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Crkl
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms: Crkol, snoop, 1110025F07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12929
HGNC: HGNC:2363
Homologene: 38021
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Dlc1
Name: deleted in liver cancer 1
Synonyms: Arhgap7, p122-RhoGAP, STARD12, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Il17rd
Name: interleukin 17 receptor D
Synonyms: 2810004A10Rik, Sef-S, Sef
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 171463
VEGA: 14
Homologene: 9717
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Desrt, 5430435G07Rik, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Arl15
Name: ADP-ribosylation factor-like 15
Synonyms: Arfrp2, C230032K13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218639
Homologene: 56843
Por
Name: cytochrome p450 oxidoreductase
Synonyms: 4933424M13Rik, CPR, CYPOR, NADH cytochrome P450 oxydoreductase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18984
HGNC: HGNC:9208
Homologene: 725
Zfhx3
Name: zinc finger homeobox 3
Synonyms: A230102L03Rik, Atbf1, Sci, WBP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: C130040D16Rik, MICAL-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Prr14l
Name: proline rich 14-like
Synonyms: 6030436E02Rik, C330019G07Rik, Prl14l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 215476
Homologene: 65866
Dpy19l2
Name: dpy-19 like 2
Synonyms: 4932443J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320752
VEGA: 9
Homologene: 77569
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Herpud2
Name: HERPUD family member 2
Synonyms: 5031400M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80517
VEGA: 9
Homologene: 10756
Chchd4
Name: coiled-coil-helix-coiled-coil-helix domain containing 4
Synonyms: 2810014D17Rik, 2410012P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72170
Homologene: 14846
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: LOC384311, mSSH-1L
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231637
Homologene: 41299
Ctnnd2
Name: catenin delta 2
Synonyms: Nprap, catenin (cadherin associated protein), delta 2, Catnd2, neurojugin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Cpne5
Name: copine V
Synonyms: A830083G22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240058
HGNC: HGNC:2318
Homologene: 23266
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh4, Zfh-4, C130041O22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80892
Homologene: 23477
Stk10
Name: serine/threonine kinase 10
Synonyms: Gek1, Lok
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20868
Homologene: 38122
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: 1700010C24Rik, A830008O07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Rcan3
Name: regulator of calcineurin 3
Synonyms: Dscr1l2, Csp3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53902
HGNC: HGNC:3042
Homologene: 8388
Ampd3
Name: adenosine monophosphate deaminase 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11717
HGNC: HGNC:470
Homologene: 408
Slc4a9
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 9
Synonyms: D630024F24Rik, AE4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240215
VEGA: 18
Homologene: 23732
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Prkcg
Name: protein kinase C, gamma
Synonyms: Pkcc, PKCgamma, Prkcc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18752
HGNC: HGNC:9402
Homologene: 20602
Or13c3
Name: olfactory receptor family 13 subfamily C member 3
Synonyms: GA_x6K02T2N78B-7137430-7138383, Olfr273, MOR262-8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258821
Homologene: 73999
Cdh17
Name: cadherin 17
Synonyms: BILL-cadherin, LI-cadherin, HPT-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Manea
Name: mannosidase, endo-alpha
Synonyms: 4932703L02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242362
Homologene: 11636
Zfp521
Name: zinc finger protein 521
Synonyms: B930086A16Rik, Evi3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225207
VEGA: 18
Homologene: 9151
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Clta
Name: clathrin light chain A
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12757
HGNC: HGNC:2090
Homologene: 1384
Adam28
Name: a disintegrin and metallopeptidase domain 28
Synonyms: D430033C21Rik, MDC-L, Dtgn1, C130072N01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13522
VEGA: 14
HGNC: HGNC:206
Homologene: 40705
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Kos1, Tnk1b, Tnk1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83813
Homologene: 2966
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Tmx3
Name: thioredoxin-related transmembrane protein 3
Synonyms: 6430411B10Rik, A730024F05Rik, Txndc10
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 67988
VEGA: 18
Homologene: 10381
Fcgbp
Name: Fc fragment of IgG binding protein
Synonyms: A430096B05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 215384
Homologene: 68369
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Tsga10
Name: testis specific 10
Synonyms: Mtsga10, 4933432N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211484
Homologene: 23531
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: OATP4C1, OATP-M1, PRO2176, SLC21A20, OATP-H, C330017E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: Ggtp, CD224, dwg, GGT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14598
Homologene: 68450
Actr3b
Name: ARP3 actin-related protein 3B
Synonyms: ARP11, Arp3b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242894
Homologene: 4180
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: Hmha1, 6330406L22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70719
Homologene: 69120
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Rps6kb2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: S6K2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58988
Homologene: 68374
Or5b108
Name: olfactory receptor family 5 subfamily B member 108
Synonyms: MOR202-13, GA_x6K02T2RE5P-3517488-3518411, Olfr1462
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258688
HGNC: HGNC:8324
Homologene: 133607
AW146154
Name: expressed sequence AW146154
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101835
Homologene: 134516
Lipf
Name: lipase, gastric
Synonyms: 2310051B21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67717
HGNC: HGNC:6622
Homologene: 68139
Sppl2b
Name: signal peptide peptidase like 2B
Synonyms: 3110056O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 73218
VEGA: 10
Homologene: 10605
Gja5
Name: gap junction protein, alpha 5
Synonyms: Cx40, Gja-5, connexin 40
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14613
HGNC: HGNC:4279
Homologene: 3856
Cnpy1
Name: canopy FGF signaling regulator 1
Synonyms: 1500012D20Rik, 9630008K15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269637
Homologene: 89678
Trav5-4
Name: T cell receptor alpha variable 5-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21507
Tnfrsf13c
Name: tumor necrosis factor receptor superfamily, member 13c
Synonyms: Bcmd1, 2010006P15Rik, Baffr, Lvis22, Bcmd-1, BAFF-R
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72049
VEGA: 15
Homologene: 49897
Rnf223
Name: ring finger 223
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100045778
Homologene: 27073
Trav14n-3
Name: T cell receptor alpha variable 14N-3
Synonyms: 100043308, X76971
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100043308
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,167,697 bp
  • C to T, chromosome 1 at 37,835,148 bp
  • T to A, chromosome 1 at 96,828,942 bp
  • A to G, chromosome 3 at 5,242,110 bp
  • G to T, chromosome 3 at 63,698,169 bp
  • A to T, chromosome 3 at 97,051,641 bp
  • C to T, chromosome 4 at 11,814,698 bp
  • T to A, chromosome 4 at 26,328,234 bp
  • T to G, chromosome 4 at 44,025,494 bp
  • G to A, chromosome 4 at 52,855,692 bp
  • A to T, chromosome 4 at 135,412,488 bp
  • A to G, chromosome 4 at 154,265,085 bp
  • A to G, chromosome 4 at 156,132,203 bp
  • T to C, chromosome 5 at 21,614,666 bp
  • T to C, chromosome 5 at 25,848,366 bp
  • T to C, chromosome 5 at 28,207,284 bp
  • C to T, chromosome 5 at 32,828,245 bp
  • A to T, chromosome 5 at 113,950,551 bp
  • T to C, chromosome 5 at 135,734,505 bp
  • C to T, chromosome 6 at 91,467,772 bp
  • G to A, chromosome 6 at 120,934,948 bp
  • G to A, chromosome 7 at 3,329,964 bp
  • A to G, chromosome 7 at 27,361,577 bp
  • T to C, chromosome 7 at 28,091,503 bp
  • G to A, chromosome 7 at 41,480,732 bp
  • G to T, chromosome 7 at 110,777,842 bp
  • A to T, chromosome 8 at 36,582,740 bp
  • T to C, chromosome 8 at 108,951,644 bp
  • T to C, chromosome 9 at 24,696,163 bp
  • T to C, chromosome 9 at 25,110,606 bp
  • T to C, chromosome 10 at 68,118,345 bp
  • T to C, chromosome 10 at 75,585,456 bp
  • C to A, chromosome 10 at 80,031,001 bp
  • C to T, chromosome 10 at 80,867,419 bp
  • A to T, chromosome 11 at 32,577,764 bp
  • T to C, chromosome 11 at 69,853,577 bp
  • T to C, chromosome 12 at 81,420,377 bp
  • T to C, chromosome 12 at 86,882,798 bp
  • A to G, chromosome 13 at 113,967,672 bp
  • C to A, chromosome 14 at 27,039,210 bp
  • A to T, chromosome 14 at 53,370,494 bp
  • A to T, chromosome 14 at 53,704,445 bp
  • T to A, chromosome 14 at 61,203,228 bp
  • T to A, chromosome 14 at 68,634,833 bp
  • A to G, chromosome 15 at 31,027,484 bp
  • T to C, chromosome 15 at 47,669,143 bp
  • T to C, chromosome 15 at 71,462,580 bp
  • T to C, chromosome 15 at 82,224,140 bp
  • T to C, chromosome 16 at 17,452,502 bp
  • T to C, chromosome 17 at 29,226,198 bp
  • T to A, chromosome 17 at 67,737,554 bp
  • T to C, chromosome 18 at 13,844,356 bp
  • A to G, chromosome 18 at 36,528,377 bp
  • C to T, chromosome 18 at 90,540,030 bp
  • A to G, chromosome 19 at 4,157,021 bp
  • T to A, chromosome 19 at 13,190,772 bp
  • A to T, chromosome 19 at 33,965,698 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7649 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045646-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.