Strain Name:
C57BL/6J-MtgxR7676Btlr/Mmmh
Stock Number:
045647-MU
Citation ID:
RRID:MMRRC_045647-MU
Other Names:
R7676 (G1)
Major Collection:

Strain Information

Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, DPEAAE, Cspg2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Dnajc21
Name: DnaJ heat shock protein family (Hsp40) member C21
Synonyms: 9930116P15Rik, 4930461P20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78244
Homologene: 6752
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: Rnf164, D930043C02Rik, 2900024N03Rik, 9430019J22Rik, Mnab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Zfat
Name: zinc finger and AT hook domain containing
Synonyms: LOC380993, Zfp406, Zfat1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380993
Homologene: 16829
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11538
Homologene: 7617
Pip4k2b
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Synonyms: c11, PI5P4Kbeta, Pip5k2b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108083
HGNC: HGNC:8998
Homologene: 2634
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, Acc1, LOC327983, Acac, A530025K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Plxdc2
Name: plexin domain containing 2
Synonyms: 1200007L24Rik, Tem7r, 5430431D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67448
Homologene: 41666
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171395
Homologene: 51376
Kcnab3
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 3
Synonyms: mKv(beta)4, Kcnab4, C330022D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16499
HGNC: HGNC:6230
Homologene: 55844
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Foxd3
Name: forkhead box D3
Synonyms: Genesis, Hfh2, CWH3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15221
HGNC: HGNC:3804
Homologene: 49239
Fli1
Name: Friend leukemia integration 1
Synonyms: Sic1, SIC-1, EWSR2, Fli-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14247
HGNC: HGNC:3749
Homologene: 55624
Akap6
Name: A kinase anchor protein 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: 1700029F22Rik, mRib72-1, myoclonin1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, 9430031G15Rik, b2b1000Clo, Ltbp1L
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Or10j7
Name: olfactory receptor family 10 subfamily J member 7
Synonyms: GA_x6K02T2R7CC-664297-665229, MOR267-5, Olfr1406
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258758
Homologene: 133644
Nat8f2
Name: N-acetyltransferase 8 (GCN5-related) family member 2
Synonyms: Cml2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93673
Tulp2
Name: TUB like protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56734
Homologene: 2492
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Keg1
Name: kidney expressed gene 1
Synonyms: GS4059, 0610008P16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 64697
Homologene: 69461
Or6c6c
Name: olfactory receptor family 6 subfamily C member 6C
Synonyms: GA_x6K02T2PULF-11383575-11384519, MOR110-7, Olfr804
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258068
Homologene: 133581
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: MOR259-1, GA_x6K02T2QD9B-18602750-18603691, MOR259-13, MOR259-1, Olfr1519, Olfr1328
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216188
Homologene: 51942
Palm3
Name: paralemmin 3
Synonyms: 4432412L15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74337
Homologene: 53493
Lrrc45
Name: leucine rich repeat containing 45
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217366
Homologene: 17019
Fars2
Name: phenylalanine-tRNA synthetase 2, mitochondrial
Synonyms: 2810431B21Rik, 6720478K01Rik, Fars1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69955
VEGA: 13
Homologene: 4788
Stk32c
Name: serine/threonine kinase 32C
Synonyms: YANK3, Pkek
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57740
Homologene: 75157
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: PDILT, 1700007B13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71830
Homologene: 18382
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Nckipsd
Name: NCK interacting protein with SH3 domain
Synonyms: WISH, SPIN90, AF3P21, ORF1, DIP1, Wasbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80987
Homologene: 9514
Gem
Name: GTP binding protein overexpressed in skeletal muscle
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14579
HGNC: HGNC:4234
Homologene: 38024
Vmn1r51
Name: vomeronasal 1 receptor 51
Synonyms: V1r1, VN12, V1ra1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22296
Homologene: 130651
Ighv10-3
Name: immunoglobulin heavy variable V10-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380809
HGNC: HGNC:5623
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 20,967,369 bp
  • T to G, chromosome 1 at 46,234,164 bp
  • T to A, chromosome 1 at 173,183,553 bp
  • C to T, chromosome 2 at 16,712,083 bp
  • A to T, chromosome 2 at 37,405,332 bp
  • T to C, chromosome 2 at 76,814,607 bp
  • G to A, chromosome 2 at 168,183,447 bp
  • T to C, chromosome 3 at 38,891,697 bp
  • T to A, chromosome 3 at 59,217,757 bp
  • C to A, chromosome 4 at 11,711,170 bp
  • G to T, chromosome 4 at 99,656,914 bp
  • A to G, chromosome 4 at 118,934,150 bp
  • A to T, chromosome 6 at 85,868,212 bp
  • T to C, chromosome 6 at 90,129,455 bp
  • G to T, chromosome 7 at 45,521,027 bp
  • C to A, chromosome 7 at 105,684,087 bp
  • A to T, chromosome 7 at 119,494,997 bp
  • A to G, chromosome 7 at 125,850,377 bp
  • T to A, chromosome 7 at 139,105,304 bp
  • T to C, chromosome 8 at 84,029,445 bp
  • T to A, chromosome 9 at 7,503,549 bp
  • T to A, chromosome 9 at 32,428,030 bp
  • T to C, chromosome 9 at 108,814,954 bp
  • G to T, chromosome 10 at 83,508,111 bp
  • G to T, chromosome 10 at 129,705,286 bp
  • C to T, chromosome 11 at 8,962,708 bp
  • A to G, chromosome 11 at 69,326,727 bp
  • A to G, chromosome 11 at 84,294,987 bp
  • A to T, chromosome 11 at 97,720,362 bp
  • G to A, chromosome 11 at 120,720,322 bp
  • A to G, chromosome 12 at 52,886,850 bp
  • T to A, chromosome 12 at 72,102,047 bp
  • G to A, chromosome 12 at 113,544,576 bp
  • A to G, chromosome 12 at 114,523,679 bp
  • C to A, chromosome 13 at 36,205,043 bp
  • A to T, chromosome 13 at 89,691,789 bp
  • T to C, chromosome 15 at 10,462,344 bp
  • A to C, chromosome 15 at 68,224,844 bp
  • A to G, chromosome 17 at 75,291,297 bp
  • T to G, chromosome 19 at 12,716,045 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7676 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045647-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.