Strain Name:
C57BL/6J-MtgxR7586Btlr/Mmmh
Stock Number:
045668-MU
Citation ID:
RRID:MMRRC_045668-MU
Other Names:
R7586 (G1)
Major Collection:

Strain Information

Cdh3
Name: cadherin 3
Synonyms: Cadp, Pcad, P-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12560
HGNC: HGNC:1762
Homologene: 20425
Igfbp2
Name: insulin-like growth factor binding protein 2
Synonyms: Igfbp-2, IGFBP-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16008
HGNC: HGNC:5471
Homologene: 499
Stk24
Name: serine/threonine kinase 24
Synonyms: 1810013H02Rik, STE20
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223255
VEGA: 14
Homologene: 20793
Trpm7
Name: transient receptor potential cation channel, subfamily M, member 7
Synonyms: Ltpr7, 2310022G15Rik, LTRPC7, 5033407O22Rik, TRP-PLIK, CHAK, CHAK1, 4833414K03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58800
Homologene: 9774
Jpt1
Name: Jupiter microtubule associated homolog 1
Synonyms: Hn1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15374
Homologene: 7364
Top3b
Name: topoisomerase (DNA) III beta
Synonyms: Topo III beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21976
Homologene: 2923
Fbrsl1
Name: fibrosin-like 1
Synonyms: 2410025L10Rik, Gm29766, LOC381668
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381668
Homologene: 45966
Slain2
Name: SLAIN motif family, member 2
Synonyms: 8030444K12Rik, 5033405K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Fry
Name: FRY microtubule binding protein
Synonyms: cg003, 9330186A19Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320365
Homologene: 113770
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Asr2, 2810019G02Rik, Ars2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Resf1
Name: retroelement silencing factor 1
Synonyms: 2810474O19Rik, GET
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67246
Homologene: 19251
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Supt16
Name: SPT16, facilitates chromatin remodeling subunit
Synonyms: Spt16, Fact140, Cdc68, Supt16h
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 114741
VEGA: 14
Homologene: 5207
Wwc1
Name: WW, C2 and coiled-coil domain containing 1
Synonyms: Kibra
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211652
Homologene: 69180
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Pip4k2c
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Synonyms: Pip5k2c
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117150
VEGA: 10
Homologene: 23484
Pum2
Name: pumilio RNA-binding family member 2
Synonyms: 5730503J23Rik, Pumm2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 80913
Homologene: 69183
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Med13
Name: mediator complex subunit 13
Synonyms: Thrap1, Trap240, 1110067M05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327987
Homologene: 21067
Ganab
Name: alpha glucosidase 2 alpha neutral subunit
Synonyms: G2an, GluII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14376
VEGA: 19
HGNC: HGNC:4138
Homologene: 5426
Scamp3
Name: secretory carrier membrane protein 3
Synonyms: Sc3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24045
Homologene: 4164
Gab2
Name: growth factor receptor bound protein 2-associated protein 2
Synonyms: p97, D130058I17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14389
Homologene: 69067
Rdh11
Name: retinol dehydrogenase 11
Synonyms: 2610319N22Rik, Mdt1, M42C60, Arsdr1, Psdr1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17252
Homologene: 100724
Msh3
Name: mutS homolog 3
Synonyms: Rep3, Rep-3, D13Em1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Eloa
Name: elongin A
Synonyms: Tceb3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27224
Homologene: 37746
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, 4930516E05Rik, D330038K10Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: C530024J06Rik, PAF65A, 2810417N14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225895
Homologene: 4728
Tmem81
Name: transmembrane protein 81
Synonyms: 4930429O20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74626
Homologene: 12579
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: 2310051N18Rik, D530030H10Rik, 2410044A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Ercc5
Name: excision repair cross-complementing rodent repair deficiency, complementation group 5
Synonyms: Xpg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22592
HGNC: HGNC:3437
Homologene: 133551
Lama2
Name: laminin, alpha 2
Synonyms: mer, merosin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 373864
Homologene: 69400
Nlrp9a
Name: NLR family, pyrin domain containing 9A
Synonyms: Nalp-theta, Nalp9a, D7Ertd565e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233001
Homologene: 116072
Pabpc6
Name: poly(A) binding protein, cytoplasmic 6
Synonyms: 4932702K14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67543
VEGA: 17
Homologene: 129776
Junb
Name: jun B proto-oncogene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16477
HGNC: HGNC:6205
Homologene: 7390
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Ccdc168
Name: coiled-coil domain containing 168
Synonyms: Gm8251
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 102636082
VEGA: 1
Homologene: 141149
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, mm1beta, myr2, C80397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Ankdd1a
Name: ankyrin repeat and death domain containing 1A
Synonyms: LOC384945, EG330963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330963
VEGA: 9
Homologene: 65619
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Zfp777
Name: zinc finger protein 777
Synonyms: 2500002G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72306
Homologene: 56721
Serpinb9b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9b
Synonyms: ovalbumin, Spi10, 1600019A21Rik, R86, SPI-CI
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20706
HGNC: HGNC:8955
Homologene: 137240
Cfh
Name: complement component factor h
Synonyms: Sas1, Mud-1, Sas-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12628
HGNC: HGNC:4883
Homologene: 20086
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Slc23a1
Name: solute carrier family 23 (nucleobase transporters), member 1
Synonyms: Slc23a2, YSPL3, SVCT1, D18Ucla2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20522
Homologene: 40769
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Tubal3
Name: tubulin, alpha-like 3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238463
VEGA: 13
Homologene: 23488
Fstl4
Name: follistatin-like 4
Synonyms: SPIG1, B230374F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Or5d43
Name: olfactory receptor family 5 subfamily D member 43
Synonyms: Olfr1173, GA_x6K02T2Q125-49759783-49758845, MOR174-20_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404329
Homologene: 128091
Or5p6
Name: olfactory receptor family 5 subfamily P member 6
Synonyms: Olfr478, MOR204-13, GA_x6K02T2PBJ9-10361879-10360935
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258729
Homologene: 128076
Catsperz
Name: cation channel sperm associated auxiliary subunit zeta
Synonyms: 1700019N12Rik, A430107B04Rik, Tex40
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67077
VEGA: 19
Homologene: 85555
Ndufaf4
Name: NADH:ubiquinone oxidoreductase complex assembly factor 4
Synonyms: 1110007M04Rik, 3000003G13Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68493
Homologene: 40928
Or5g23
Name: olfactory receptor family 5 subfamily G member 23
Synonyms: Olfr1000, GA_x6K02T2Q125-47087719-47086775, MOR175-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257899
Spinkl
Name: serine protease inhibitor, Kazal type-like
Synonyms: 9530002K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77424
VEGA: 18
Homologene: 128818
Gfy
Name: golgi-associated olfactory signaling regulator
Synonyms: Goofy, Gm581
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100039953
Homologene: 85248
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Klhl41
Name: kelch-like 41
Synonyms: LOC228003, Kbtbd10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228003
Homologene: 4421
Ankrd31
Name: ankyrin repeat domain 31
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 625662
Homologene: 110355
Krtap10-24
Name: keratin associated protein 10-24
Synonyms: Gm3285
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100041351
VEGA: 10
Homologene: 115744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 44,060,013 bp
  • A to G, chromosome 1 at 44,175,851 bp
  • A to C, chromosome 1 at 51,778,324 bp
  • A to G, chromosome 1 at 54,403,593 bp
  • A to T, chromosome 1 at 72,849,148 bp
  • A to T, chromosome 1 at 132,507,773 bp
  • C to T, chromosome 1 at 140,147,721 bp
  • A to T, chromosome 2 at 69,674,724 bp
  • G to C, chromosome 2 at 85,608,184 bp
  • T to A, chromosome 2 at 88,274,450 bp
  • A to T, chromosome 2 at 126,810,165 bp
  • A to G, chromosome 3 at 89,180,366 bp
  • C to T, chromosome 4 at 24,901,829 bp
  • C to A, chromosome 4 at 63,225,041 bp
  • A to G, chromosome 4 at 136,007,199 bp
  • G to A, chromosome 5 at 72,965,822 bp
  • A to C, chromosome 5 at 110,378,154 bp
  • T to C, chromosome 5 at 137,302,195 bp
  • T to C, chromosome 5 at 150,426,218 bp
  • A to T, chromosome 6 at 48,029,218 bp
  • A to T, chromosome 6 at 102,420,427 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • A to T, chromosome 6 at 149,326,793 bp
  • T to A, chromosome 7 at 7,293,959 bp
  • A to T, chromosome 7 at 26,557,296 bp
  • C to T, chromosome 7 at 45,177,538 bp
  • C to T, chromosome 7 at 97,301,438 bp
  • T to A, chromosome 7 at 108,031,921 bp
  • C to T, chromosome 8 at 11,530,321 bp
  • T to C, chromosome 8 at 84,978,173 bp
  • T to G, chromosome 8 at 86,029,597 bp
  • T to C, chromosome 8 at 106,511,343 bp
  • C to T, chromosome 9 at 65,502,184 bp
  • T to C, chromosome 10 at 27,101,393 bp
  • T to C, chromosome 10 at 77,862,041 bp
  • A to G, chromosome 10 at 116,343,874 bp
  • A to T, chromosome 10 at 120,077,138 bp
  • A to G, chromosome 10 at 127,199,086 bp
  • A to T, chromosome 11 at 35,844,195 bp
  • A to G, chromosome 11 at 53,072,429 bp
  • A to T, chromosome 11 at 75,657,519 bp
  • A to T, chromosome 11 at 86,271,002 bp
  • T to A, chromosome 11 at 115,498,195 bp
  • C to T, chromosome 11 at 116,455,624 bp
  • A to G, chromosome 12 at 8,747,206 bp
  • T to C, chromosome 12 at 79,185,183 bp
  • A to C, chromosome 13 at 3,928,198 bp
  • T to C, chromosome 13 at 33,039,760 bp
  • T to A, chromosome 13 at 59,718,380 bp
  • A to G, chromosome 13 at 92,349,332 bp
  • A to G, chromosome 13 at 96,832,054 bp
  • A to T, chromosome 14 at 52,173,556 bp
  • C to T, chromosome 14 at 121,302,287 bp
  • C to T, chromosome 15 at 7,208,601 bp
  • G to A, chromosome 16 at 16,891,368 bp
  • A to T, chromosome 17 at 9,668,682 bp
  • C to A, chromosome 17 at 34,716,408 bp
  • G to A, chromosome 18 at 35,625,838 bp
  • G to T, chromosome 18 at 37,295,804 bp
  • C to T, chromosome 18 at 43,540,611 bp
  • A to G, chromosome 18 at 44,174,589 bp
  • A to G, chromosome 18 at 78,030,060 bp
  • A to T, chromosome 19 at 6,922,561 bp
  • C to T, chromosome 19 at 8,783,846 bp
  • A to T, chromosome 19 at 8,911,352 bp
  • T to A, chromosome 19 at 16,647,598 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7586 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045668-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.